hindrance of its benzene rings being so close together. It causes the molecule to twist. E-Stilbene on the other hand does not have to twist due to hindrance and thus has full conjugation. The recrystallized E-Stilbene product is mostly pure as its NMR matches the literature value for E-Stilbene except for the small peak at 6.6 ppm due to a small amount of leftover Z-Stilbene2. This reaction could be improved by using Bromine instead of Iodine because Iodine is very slow and it is possible that more
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Chem 51LC Experiment 6 Lab Report Aldol Reaction Purpose: The purpose of this experiment is to be able to conduct an aldol condensation reaction using an unknown aldehyde and an unknown ketone. H NMR is used to identify the unknown aldehyde and ketone. Melting point is used to identify the aldol condensation reaction. Theory: Condensation reaction is also known as a dehydration reaction. In the mechanism of condensation reaction‚ a bond is formed between two molecules and creates water as a
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involved protecting the ketone of ethyl acetoacetate with a ketal group‚ followed by preparation and reaction with Grignard‚ then purification by extraction and recrystallization. The yield was 78.5%‚ but there are impurities present suggested by 1H-NMR‚ IR‚ and TLC. However‚ the results do indicate the desired hydroxyketone was formed. Introduction: The purpose of this multi-step lab was to synthesize 4-hydroxy-4‚4-diphenylbutan-2-one from ethyl acetoacetate. The Grignard reaction is widely used
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yield and 4.2% yield respectively‚ product 7 was white with a 42.5% yield‚ and product 8 was golden with a 78.7% yield (Table 1). Refer to Figure 1 for TLC plates and Table 1 for the isolated products’ associated melting point ranges‚ IR‚ MS‚ and 1H-NMR data. The mechanisms for each synthetic step is presented in Scheme 1 to Scheme 5. Refer to Scheme 6 for the general scheme with possible side products. Discussion: The observed color for all the products matched the literature‚ product
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Structural Elucidation The synthesized compound was structurally characterized by IR‚ NMR and mass spectropho-tometer. An IR spectral study was done with Shimadzu Corporation‚ Japan. An NMR spec-tral study was done with Bruker Fourier- NMR spectrometer. Mass spectra of the samples were recorded on a Waters e 2695-Waters 3100 instruments with ESI-PMT arrangement as the mode of ionization and type of detector respectively
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Affects of Hydrogen Peroxide Equivalents on Green Synthesis of Adipic Acid. Andrew R. Glessman*‚ Chase W. Turner‚ Audra Cokain‚ Jacob Kindred‚ Darryl Watkins Department of Chemistry and Chemical Biology‚ IUPU‚ 402 N. Blackford St‚ Indianapolis‚ IN 46202 aglessma@umail.iu.edu April 25‚ 2014 Figure _______________________________________________________________Abstract- The synthesis of adipic acid has been a growing topic of discussion due to the harmful impact it has on the environment
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benzyltriethylammonium chloride has both hydrophilic and hydrophobic properties‚ it could cross the phase boundary and facilitated the transport of the hydroxide ion from the aqueous phase to the organic phase. Expected spectral changes in IR and 13C-NMR Procedure To begin‚ 0.324g of cyclohexene was mixed with 1 ml of 50% aqueous sodium hydroxide‚ 1ml of chloroform and 0.040g of the phase transfer catalyst benzyltriethylammonium chloride. The reaction was stirred and heated at 40 degrees Celsius
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Article pubs.acs.org/jmc Thiazolopyridine Ureas as Novel Antitubercular Agents Acting through Inhibition of DNA Gyrase B Manoj G. Kale‚† Anandkumar Raichurkar‚†‚∇ Shahul Hameed P‚†‚∇ David Waterson‚†‚○ David McKinney‚∥ M. R. Manjunatha‚† Usha Kranthi‚† Krishna Koushik‚† Lalit kumar Jena‚† Vikas Shinde‚† Suresh Rudrapatna‚† Shubhada Barde‚† Vaishali Humnabadkar‚‡ Prashanti Madhavapeddi‚‡ Halesha Basavarajappa‚‡ Anirban Ghosh‚‡ VK Ramya‚‡ Supreeth Guptha‚‡ Sreevalli Sharma‚‡ Prakash Vachaspati
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time to dry the product with the vacuum filter—since we had to evacuate the building due to the fire alarm. If we were able to vacuum filter our product more‚ the percent yield would be close to 100%. 1. Assign the peaks in your NMR spectrum of your salicylic acid. See NMR spectrum on back 2. Assign the peaks in the IR spectrum of your salicylic acid. The IR spectrum was not performed since we ran out of time due to the fire alarm. 3. What was the purpose of the hydrochloric acid? Methyl salicylate
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configuration is predominantly. Finally‚ hydrolysis of the ester then provides (S)-ibuprofen in a relatively high yield. all reaction were monitored by TLC at room temperature with appropriate solvent system which states in experiment section. IR‚ 1H-NMR‚ 13C-NMR‚ polarimetry and melting point range were used to define the product and its purity. Introduction Racemic mixture of ibuprofen is sold in the market‚ however only the (S)-enantiomer is responsible for the desired therapeutic effects. 1 Although
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