magnesium and ether. Phenylmagnesium bromide was then transformed into a tertiary alcohol called triphenylmethanol‚ through addition of another compound called benzophenone‚ as well as additional ether. The end product of triphenylmethanol was analyzed via NMR and IR. Figure 1: Preparation of the Grignard agent by combining bromobenzene with magnesium and ether to produce phenylmagnesium bromide. Figure 2: Production of triphenylmethanol by combining benzophenone and the Grignard reagent. Introduction
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molar mass (g/mol) To further enforce the conclusions drawn regarding the acids identity from the titration (crotonic acid for my sample)‚ NMR spectra were given for the unknown acid. A little bit of research reveals that the NMR spectra for crotonic acid is exactly what was given on the Human Metabolome Database (http://www.hmdb.ca/). Copies of their NMR spectra are printed and though this data is pretty convincing‚ it can only be reinforced. Three more tests were conducted. The
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RAPPTH-Co (II): H1 NMR: δ2.61 (s‚CH3‚3H)‚2.49(s‚CH3‚3H)‚6.40- 7.97 (m‚pyH‚7H )‚ 9.98(s‚ OH.IH)‚ 11.29ppm (s‚ NH‚ 1H). IR (KBr): 3480(OH‚ water)‚ 3227(ph O-H)‚ 1585(C=N)‚ 3349(N-H)‚ 1666 (C=O)‚ 554(M-O)‚ 436 cm-1 (M-N).RAPPTH-Cu (II): H1 NMR: δ2.73 (s‚CH3 ‚3H)‚2.50 (s‚CH3‚ 3H)‚ 6.42- 7.95(m‚pyH‚7H)‚ 10.14 (s‚OH.IH)‚ 11.30ppm (s‚NH‚1H). IR (KBr): 3420(OH‚ water)‚ 3230(ph O-H)‚
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Spectroscopy (nujol) are carbonyl peaks (1773.4 cm-1)‚ Sp3 C-H peaks (2921.5 cm-1)‚ Sp2 C-H (3000 cm-1). The carbonyl peaks prove the presence of an acid anhydride. H’NMR (CDCL3) 6.287ppm (t‚ 2H)‚ 3.674ppm (m‚ 2H)‚ 3.483ppm (m‚ 2H)‚ 1.697ppm (m‚ 2H). 13C NMR (CDCL3) 172.291‚ 135.913‚ 53.109‚ 47.572‚ 46.288. Next‚ hydrolysis of the anhydride took place. The anhydride was combined with distilled water in a 125 mL Erlenmeyer flask and heated. After twenty minutes the solid is partially dissolved and removed
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IR‚ mass‚ and NMR spectroscopy. The rate of reactions‚ and
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was recrystallized in aqueous EtOH (70%) to give pure products. Selected spectra: 3 -(2′-benzothiazolo)-2‚3-dihydro-2-(4-chlorophenyl)-quinazolin-4(1H)-ones ( Table 1 Entry 1): m.p 229-239 oC; IR (KBr): υ = 3335‚ 1634‚ 1502‚ 1406‚ 1254‚ 740cm-1; 1H NMR (400 MHz‚ DMSO-d6): δ = 6. 81 (t‚ 1H‚ J = 8 Hz)‚ 6.85 (d‚ 1H‚ J = 8 Hz)‚ 7.30 (d‚ 2H‚ J = 8 Hz)‚ 7.36 (t‚ 3H‚ J = 8 Hz)‚
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UV-Vis spectra was recorded for the colorless sample. The solution was irradiated using a lamp resulting in a purple solution and the UV-Vis spectrum was retaken. UV (): 524.92nm ε colourless (45.2M-1cm-1) coloured (760M-1cm-1) 1H NMR (300MHz‚ CDCl3) δ 7.26 (30H‚ m) 13C NMR DEPT (75MHz‚ CDCl3) δ 166.5‚ 149.0‚ 138.11‚ 137.9‚ 134.4‚ 134.4‚ 132.7‚ 132.01-126.13‚ 112.38. Results and Discussion The triphenylimidazole dimer that was synthesized displayed a melting range of 199.8-200.3 ºC which is higher
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Arene Molybdenum lab Introduction: Organometallic chemistry is the study of chemical compounds that contain carbon atoms bound to a metal atom. Organometallic compounds can contain main group elements‚ or more metallic elements such as zinc or carbon. These compounds tend to have carbon atoms bound to the metal center by σ-bonds. Alternatively‚ transition metals can be involved in the compound‚ which leads to a variety of interesting and diverse chemical characteristics. For example‚ a promising
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DISCIPLINE OF PHARMACEUTICAL CHEMISTRY DRUG DESIGN AND DISCOVERY BY: xxxxxxx Introduction A drug is a substance that we used mostly in our daily lives. It is a chemical substance with physiological effects when ingested or introduced into our bodies. The response produce can either be beneficial or harmful. Toxins and poisons can be classified as drugs. This report the term ‘drug’ is for medicinal or pharmaceutical purposes. Drugs used to prevent or treat diseases. Drug design
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and indeed there is a very small multiplet peak with integration equal to one hydrogen at 5.32 ppm; since the HCl hydrogen is labile and thus would most likely not show up as a clean singlet on the NMR spectrum‚ there is strong evidence in favor of bupropion hydrochloride as the major product. The 13C NMR spectrum is unable to show the presence of HCl since no carbon is present in the molecule‚ but it does agree well with what would be expected from just
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