Lab 1: Synthesis of Aspirin Introduction: The purpose of this lab was to demonstrate the ability to easily alter the molecular structure of a compound to greatly increase its utility. In this case‚ an acetyl group was added to salicylic acid‚ a naturally occurring compound with significant pharmaceutical value. Without the addition of the acetyl group‚ salicylic acid is an irritant to the gastro-intestinal (GI) tract. Once the acetyl group is added via a simple reaction‚ acetylsalicylic
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Experiment 9-Dehydration of 2-methylcyclohexanol Name______________________________________________________________________ Lab Partner_________________________________________________________________ Lab Day and Time____________________________________________________________ Report appearance (Typed‚ on time‚ in order‚ presentable‚ complete) 1 2 3 4 5 Abstract 1 2 3 4 5 Introduction 1 2 3 4
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The Grignard Synthesis of Triphenylmethanol Organic Chemistry Lab II March 19‚ 2012 Abstract The purpose of this experiment was to synthesize the Grignard reagent‚ phenyl magnesium bromide‚ and then use the manufactured Grignard reagent to synthesize the alcohol‚ triphenylmethanol‚ by reacting with benzophenone and protonation by H3O+. The triphenylmethanol was purified by recrystallization. The melting point‚ Infrared Spectroscopy‚ 13C NMR‚ and 1H NMR were used to characterize and confirm
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Discussion and Scientific Explanations The reaction was conducted using granular tin and hydrochloric acid. This mixture provided both a source of electrons and protons1. The electrons worked as the reducing agent in this mechanism1. Granular tin was chosen over a single plate of tin due to the fact that it would take much more time and effort to fully dissolve a single plate of tin. A plate of tin would be more bonded to each other and less likely to be reactive. With the addition of the concentrated
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Chemistry F332 Notes Ions in solids and solutions: Structure of an ionic lattice (Sodium Chloride): * Consists of sodium ions (Na+) surrounded by six chloride ions (Cl-) * Chloride ions also surrounded by six sodium ions. * Held together by attraction of oppositely charged ions. * Giant ionic lattice. * Electrostatic bonds hold lattices together. * Structure is simple cubic. * Some ionic crystals contain water. * Known as water of crystallisation. * These crystals
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Experiment2: Preparation of Dibenzalacetone Aim: Using the cabon-cabon bond making ability in carbonyl chemistry‚ Dibenzalacetone is synthesized from 2 equivalent of benzaldehyde and 1 equivalent of acetone in a base catalyzed reaction. Physical Data1: *detailed risk and safety phrases are attached. substance Hazards‚ risks and safety practices MW (g/mol) Amt. Used Mol. mp (K) bp (K) density(g/cm^3) acetone R11‚ R36‚ R67‚ S9‚ S25‚ S26 58.08 0.24 g 0.004 178.2 329.4 0.79 benzaldehyde R22
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different nitrogens have been replaced by a hydrogen atom in these two variants. Later in the experiment‚ caffeine reacts with salicylic acid to form caffeine salicylate. The reaction is shown below. The nitrogen in the caffeine acts as a nucleophile‚ accepting the acidic proton from the salicylic acid. The Pka of the conjugate acid of caffeine is about 1.22‚ while the Pka of salicylic acid is 2.97. The reaction normally would be reagent favored‚ because the conjugate acid formed has a higher
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Introduction An electrophile is a reagent attracted to electrons and accepts an electron pair in order to bond to a nucleophile. Electrophiles will attack benzene and result in hydrogen substitution. However‚ this is not thermodynamically favoured because a sp3 hybridized carbon is generated‚ which disrupts the cyclic conjugation. In order to regenerate the aromatic ring‚ a proton is lost at the sp3 hybridized carbon. Thus‚ p-Nitroaniline can be prepared by means of electrophilic aromatic substitution
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Formaldehyde as a model protein crosslinking reagent. Understanding protein-protein interactions is becoming a vital study for application in the development of new age pharmaceuticals and utilization in diagnostic models. The overall aim is to gain an insight into the function and role of individual proteins with specific interest on how they react in cells‚ (Toews et al. 2008). The biopharma industry in Ireland is becoming a booming success for the economy therefore a complete understanding of
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Biochemistry Lecture Exam 1 Study Guide Chapter 1: Biochemistry: An Introduction I. Introduction a. Biochemistry: the study of molecules and chemical reactions of life b. Divided into 3 principal areas: 1. Structural chemistry of components of living matter & relationship of biological function to chemical structure 2. Metabolism – total chem reactions that occur in living matter; building & breaking down of molecules 3. Chemistry of processes & substances that store & transmit biological
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