Quinazolines are the class of chemical compounds that are pharmacologically important as therapeutic agents. They are utilized as drugs and employed in cancer chemotherapy. They act by various mechanisms. Some of them act by inhibiting antifolat thymidylate syntheses‚ while some other derivatives inhibit tubulin polymerization. They were also found to inhibit the epidermal growth factor receptor (EGFR) tyrosine kinase over expression through the inhibition of autophosphorylation of EGFR. Further
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For the treatment of cancer most of the drugs currently available but they have limited therapeutic potential because they are very toxic‚ expensive‚ highly inappropriate action in treating cancer‚ or having so many side effects like granulocytopenia‚ agranulocytosis‚ lymphocytopenia‚ alopecia‚ carcinogenicity or secondary cancer especially leukaemias and hyperuricaemia etc. Curcumin is one such natural herbal medicine‚ derived from the extraction of dried rhizome of turmeric or Curcumin longa‚
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Biocon Limited 1. Assuming Biocon receives approval for BioMAb‚ should it launch the drug immediately or conduct phase 3 trials before launch? Elaborate the various elements of your action plan. Even if the Drug Controller General of India (DCGI) grants permission for BIOMAb in fall 2006‚ Biocon should still conduct phase 3 trials before launching. Both Biocon and Clinigene are new to the industry and strong reputations have yet to be developed. Therefore‚ Biocon must means make sure BIOMAb
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Rodriguez 1 Cristian Rodriguez Jenny Bass English A99 28 Sept. 2014 Essay #2 Definition In this day and age we are constantly changing the true meaning of certain words into our own definitions. The original meaning of these words are no longer properly used or are abused with some slang term. Even though some of these words contain double meanings‚ they should still be treated with respect. One specific word that stands out to me is “cancer.” Cancer is without a doubt‚ nothing that should be
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Greg F. grew up in the 1950s in a comfortable Queens household‚ an attractive and rather gifted boy who seemed destined‚ like his father‚ for a professional career—perhaps a career in song writing‚ for which he showed a precocious talent. But he grew restive‚ started questioning things‚ as a teenager in the late ’60s; started to hate the conventional life of his parents and neighbours and the cynical‚ bellicose administration of the country. . . . Increasingly he fell out with his parents and teachers;
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As a part of the National Junior Honor Society‚ we are required to “make a difference”. There are many ways that we contribute to making a difference to a cause. For example‚ we can hold more fundraisers like car washes or even bakes sales. In my opinion‚ I would like to do these activities to help the American Cancer Society. There are different kinds of cancer‚ but they can all affect many lives. About 3‚400 people are diagnosed with cancer each day in the United States. They are left with the
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SIGNIFICANCE Hepatocellular carcinoma (HCC) is the second leading cause of cancer-death in the world. In 2012‚ 782‚000 people were diagnosed and 95% mortality rate makes it the sixth most common cancer [1]. HCC in early stages is usually asymptomatic. When symptoms do occur they are usually mistaken for other liver diseases. Therefore‚ early diagnosis of HCC is extremely challenging. Surgical resection and liver transplant are the best treatment options for early stage HCC (BCLC stage 0 or A [2])
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Sentinel Lymph Node Dissection This procedure is done in order to diagnose the cancer‚ do treatment and check the sentinel lymph nodes‚ so that the cancer cells do not spread further. It works as a substitute for the Axillary clearance method and has an added advantage of determining the stage of cancer. This method may not always detect the cancer‚ therefore the patient may require more surgery eve after this operation. Pre-Surgery The patient needs to have a thorough discussion with the doctor
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Abstract: Background: In the past two decades there have been major advancements in the diagnosis‚ treatment and prognosis of acute coronary syndromes (ACS). Biomarkers have played a crucial role in assessing the prognosis of ACS‚ cardiac troponins are still the biomarkers of choice; recently Amino-terminal pro-BNP (NT-pro-BNP) is suggested to be beneficial in measuring prognosis of the disease. NT-pro-BNP primarily arose as influential prognostic biomarker in numerous cardiovascular diseases most
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Multiple Sclerosis MS s a disease in which the T-Cells of your immune system turn against your body an attack the brain and other healthy tissue. My Mom has MS so I have been hearing about this disease my whole life. Hearing about MS my whole life you would think I would get sick of talking about it‚ but I wanted to this because even if it gets annoying sharing about MS and explaining what it is to my friends‚ it’s important that people know what it is. I know that MS isn’t as bad as Cancer
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