Experiment Four: Organic Synthesis of Aspirin Abstract The purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid (aspirin)‚ and to become familiar with the optimum conditions needed for successful yields. Aspirin is produced from an acid catalyzed reaction between salicylic acid with acetic anhydride. The crystalline aspirin is synthesized and purified by recrystallization‚ although there is not a hundred percent yield due to sources of error. Introduction
Free Aspirin Carboxylic acid Acetic acid
x 10-3‚ as shown in Equation 3. The purified aspirin product was a white powder that had a weight of .140 g. The number of moles of the purified aspirin product after extraction was 7.77 x 10-4 as shown in Equation 4. These two moles calculated a chemical yield of 54.3% as shown in Equation 5. The melting point of the pure aspirin product was ranged at 117.8-125.2C as shown in Table 1. An infrared spectrum for the pure aspirin from the synthesis was taken by using crushed crystals‚ Figure 1
Premium Chemical reaction Carboxylic acid Acetic acid
The Synthesis of Organic Aspirin ABSTRACT: The purpose of this experiment was to find out how a reaction undergoes for a globally known painkiller called aspirin‚ and to become familiar with achieving successful yields. Aspirin is synthesized from salicylic acid and acetic anhydride. Those two chemicals are mixed together along with sulfuric acid to form a crude solid. Filtration is used separate the impurities from the crude aspirin. To get purified aspirin‚ the precipitate was heated until all
Free Aspirin Acetic acid Carboxylic acid
IB1 Chemistry Practical #8 ANALYSIS OF ASPIRIN TABLETS For a long time the bark of the willow tree (salix alba) was used as a traditional medicine to relieve the fever symptoms of malaria. In the 1860’s chemists showed that the active ingredient in willow bark is salicylic acid (2-hydroxybenzoic acid) and by 1870 salicylic acid was in wide use as a pain killer (analgesic) and fever depressant (antipyretic). However‚ because it is a relatively strong acid‚ salicylic acid has the undesirable side effect
Premium Aspirin Sodium hydroxide Salicylic acid
Experimental Synthesis of Aspirin and Melting Point Purity Analysis Donald Yeargin CH 222‚ Section 24221 Department of Chemistry Portland Community College Portland‚ OR Abstract The various methods available to synthesize aspirin lead to the need to examine and evaluate production efficiency and purity. The purpose of our experiment was to synthesize acetyl salicylic acid (aspirin) and then determine the relative purity of the synthesized sample by observing the melting point temperature
Premium Aspirin Acetic anhydride Salicylic acid
Synthesis of Aspirin (Acetylsalicylic Acid) Abstract: This experiment is about the synthesis of aspirin under laboratory conditions. Aspirin is prepared by reacting salicylic acid and acetic anhydride; in the presence of sulfuric acid. After fully dissolving the salicylic acid with acetic anhydride‚ the solution is cooled and cold water is then added. Once the crystals form they are then filtered and left to dry out. There mass is measured and recorded then the yield is calculated. Introduction:
Premium Aspirin Salicylic acid Acetic acid
Aspirin Synthesis Introduction Out of all the pharmaceutical drugs in the worlds‚ aspirin is made the most. Any potential pharmacist must be familiar with synthesizing the drug. The goal of this lab is to synthesize as much pure aspirin as possible. The reactants‚ acetyl anhydride and salicylic acid‚ must react in phosphoric acid. With phosphoric acid as a catalyst‚ the reaction yields aspirin and acetic acid. The equation for the reaction is as follows: “(CH3CO)2O + HOC6H4COOH □(→┴yields ) CH3CO2C6H4CO2H
Premium Stoichiometry Reagent Aspirin
Synthesis of Aspirin Name: Xuanyi Li Teaching assistant: Deirdre Zwilling November 15‚ 2009 Purpose: To synthesize aspirin‚ a common analgesic drug‚ via nucleophilic acid-catalyzed substitution reaction of salicyclic acid with acetic anhydride. The whole reaction is catalyzed by phosphoric acid. (The experiment involved three parts: The synthesis of aspirin‚ the isolation and purification of aspirin‚ and the estimation of the purity of the final product.) [pic] Procedure[1]: A mixture
Free Aspirin Carboxylic acid Salicylic acid
Rebecca Boreham 7/1/14 Chem 2423 Experiment #5 Synthesis of Aspirin Elizabeth Ajasa Kaylee Seymour Lauren Hatfield Suveda Perikala Introduction/ Purpose Aspirin is the most commonly used drug in the United States. Forty million pounds are produced each year. The chemical name for aspirin is Acetylsalicylic acid. Aspirin is a pain reliever and a fever reducer. Aspirin originated from the bark of a White Willow Tree. Chewing the bark however is extremely acidicand irritates the mucous membranes
Premium Aspirin Salicylic acid Acetic acid
Liquid Chromatography Analysis of Aspirin Problem: Was aspirin (acetylsalicylic acid) successfully synthesized? Are there impurities or by-products present in the synthesized aspirin? How pure is the synthesized aspirin? Introduction: In the last experiment‚ aspirin was synthesized followed by characterization of the product using several different techniques. Melting point was a test that provided information about the identity and purity of the aspirin product. The iron(III)chloride test
Premium Aspirin Salicylic acid Acetic acid