Paclitaxel (PTX) Paclitaxel (PTX)‚ a member of taxane family‚ it’s an effective antineoplastic agent for treatment of many forms cancer. The success of PTX in these diseases due to a broad spectrum of antitumor activity‚ efficacy in terms of dense disseminated tumours and a unique mechanism of action. This microtubule-stabilizing drug selectively disrupts the microtubule forces‚ which induces mitotic arrest that leads to cell death(Bernabeu et al. 2017). A brief run through of its development from
Premium Paclitaxel Chemotherapy Cancer
living organism‚ are important sources of drugs. More than half of prescription and nonprescription drugs today are based on these chemicals. These include the famous anti-inflammatory drug‚ aspirin‚ from the willow tree bark‚ the anti-cancer drug‚ paclitaxel‚ isolated from the pacific yew and the antimalarial drug‚ artermisinin‚ characterized from the sweet wormwood plant. Natural products exemplify the complexity and chemical diversity in nature. Many of which inspire the syntheses of novel compounds
Premium Plant Species Pharmacology
Department of Biotechnology Ministry of Science and Technology REQUEST FOR RESEARCH PROPOSALS IN CANCER BIOLOGY DBT invites applications from eligible scientists/group of scientists for setting-up: 1. Units of Excellence (UOE) which are proposed for strengthening research resources around leaders in cancer biology with national relevance but global competitiveness; where leaders would be defined as the Core Investigator (CI) with key publications in key direction/domain of cancer biology;
Premium Proposal Proposals Cancer
Marine organisms and other novel natural sources of new cancer drugs Gilberto Schwartsmann South-American Office for Anticancer Drug Development (SOAD)‚ Comprehensive Cancer Centre (CINCAN)‚ The Lutheran University (ULBRA) & Postgraduate Course in Medicine (UFRGS)‚ Porto Alegre‚ Brazil Introduction Man has always relied on nature for survival. Since ancient times‚ nature has been our main source of food‚ protection‚ clothing‚ transportation and remedies [1‚2]. This can be illustrated by the
Premium Cancer Oncology
Medicines and Perturbation of Signaling Pathways- TAXOL TAXOL (Paclitaxel) is a breast cancer curing drug which reduces‚ slows down the growth of cancerous cells and its spread in the human body. Taxol is a clear and colorless powder with the chemical formula- C47H51NO14 and a molecular weight of 853.9 g/mol. Taxol is also used to cure other types of cancer like ovarian‚ lung and prostate. Taxol is a chemotherapeutic drug which mainly controls the growth of the cancerous cells. It belongs to the
Premium Cancer Oncology Chemotherapy
Pharmacophore development for identification of anti-lung cancer drugs Pharmacophore development for identification of anti-lung cancer drugs Sadia Abbasi a‚*‚ Shanila Emmanuel a‚ Muhammad Haseeba‚ Aftab Khalil a‚ Saima Kulsoom b‚ Hamid Rashid a‚ Raisa Bano a a b Department of Bioinformatics‚ Mohammad Ali Jinnah University‚ Islamabad‚ Pakistan Department of Chemistry‚ Quiad-e-Azam University‚ Pakistan Lung cancer is one particular type of cancer that is more deadly and common than
Premium Lung cancer
1 ONCOLOGY INDUSTRY ANALYSIS 1.1 Key trends and characteristics of Cytostatic industry • high growth rate – higher propotion of the global pharma market in the years to come • one of the fastest growing and most profitable therapeutic areas of the next few decades • shift from accute cancer treatment to chronic disease management and prevention • more and more biotech companies enter the market – connections with pharma to help through the maze of regulatory processes and clinical development
Premium European Union Chemotherapy Oncology
2.3 Amorphous forms‚ solid dispersions and cocrystals. Stable crystal forms of drugs pose problem in solubilization due to higher lattice energy. So‚ in regards to solubility‚ disordered amorphous forms provide distinct advantage over crystal forms. Hence‚ changing the solid state characteristics of pharmaceutical API renders the molecule more water soluble. But‚ excess of enthalpy‚ entropy and free energy of amorphous forms make them prone to crystallization leading to the formation of stable crystals43
Premium Chemistry Pharmacology Water
1 Roche 2013 results London‚ 30 January 2014 2 This presentation contains certain forward-looking statements. These forward-looking statements may be identified by words such as ‘believes’‚ ‘expects’‚ ‘anticipates’‚ ‘projects’‚ ‘intends’‚ ‘should’‚ ‘seeks’‚ ‘estimates’‚ ‘future’ or similar expressions or by discussion of‚ among other things‚ strategy‚ goals‚ plans or intentions. Various factors may cause actual results to differ materially in the future from those reflected in forward-looking
Premium Cancer Oncology Tumor
breast cancer. Gynecologic Oncology 2004;95(1):252-255. 12. Cardonick E‚ Iacobucci A. Use of chemotherapy during human pregnancy. The Lancet Oncology 2004;5(5):283-291. 13. Gadducci A‚ Cosio S‚ Fanucchi A‚ et al. Chemotherapy with epirubicin and paclitaxel for breast cancer during pregnancy: case report and review of the literature. Anticancer Research 2003;23(6D):5225-9. 14. Goldwasser F‚ Pico JL‚ Cerrina J‚ et al. Successful chemotherapy including epirubicin in a pregnant non-Hodgkin ’s lymphoma
Premium Chemotherapy Oncology Cancer