Mechanisms of Septic Shock Kenneth J. Goodrum‚ Ph.D. OUCOM Topics ● ● ● ● ● ● ● Definitions: SIRS‚sepsis‚shock‚MODS Morbidity/mortality of Sepsis/Shock Pathogenesis of shock Microbial triggers(endotoxin‚ TSSTs) Cytokine and non-cytokine mediators of SIRS and shock Pathophysiology of shock Therapy Systemic Inflammatory Response Syndrome (SIRS) ● ● ● ● ● Systemic inflammatory response to a variety of severe clinical insults manifested by ≥ 2 of the following conditions Temperature
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Abdominal Infection Case Study This case relates to an abdominal infection; therefore‚ purposefully look into the medication use and vocabulary as they relate to abdominal infections. Vocabulary: Before attempting to work the case study‚ define each of the vocabulary words. Although the words may have several subheadings‚ it will give you a place to begin your inquiry. When reviewing the vocabulary words‚ you might want to ask several questions: who‚ what‚ where‚ when‚ why and how. This should
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According to the World Health Organization‚ it is estimated that about 300‚000 dies worldwide each year due to burns. Burn injury causes significant dysfunction of numerous organs in the body (1-4). Extensive burns‚ Particularly‚ result in systemic problems for example sepsis (5). Taking care of burned patients imposes a large burden for health care organization. It is further than $500
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ACUTE-ON-CHRONIC LIVER FAILURE: APPLYING THE PIRO CONCEPT Danielle Adebayo‚ Vincenzo Morabito‚ Rajiv Jalan Liver Failure Group‚ UCL Institute for Liver and Digestive Health‚ UCL Medical School‚ Royal Free Hospital‚ London‚ UK Disclosure: No potential conflict of interest Citation: EMJ Hepatol. 2013;1:38-43. ABSTRACT Acute-on-chronic liver failure (ACLF)‚ a clinical syndrome associated with a dismal prognosis‚ occurs acutely in previously stable cirrhotic patients. An important feature
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Nursing Care Plan Student Name: Date: Pathophysiology (Include Normal Physiology‚ identify the Physiological Alteration‚ identify sings and symptoms). M.P. is a 56 year old African American male‚ with a history of progressive multiple sclerosis with multiple contractures‚ chronic decubitus ulcers‚ chronic indwelling urinary catheter and known osteomyelitis (infection of the bone). Mr. P. was admitted on October 25th with sepsis‚ a systemic response to infection. He presented with a fever
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|ANOKA RAMSEY COMMUNITY COLLEGE – MEDICAL PATHOPHYSIOLOGY CARD | | | |Medical Diagnosis‚ Chronic Illnesses: Appendicitis / Appendectomy
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ADN 253 FINAL STUDY GUIDE 1. Describe the pathophysiology‚ assessment‚ signs and symptoms‚ nursing diagnosis‚ medical and nursing interventions for the patient with MODS. Pathophysiology • Progressive impairment of 2 or more organ systems • Caused by immune system’s uncontrolled inflammatory response to a severe illness or injury o Inflammatory response: cytokines and chemokines out of control ▪ Peripheral vasodilation = hypotension ▪ Capillary
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x-ray‚ hypoxemia refractory to oxygensupplementation‚ and reduced lung compliance. These signs occur in the absence of left side failure. Patients with ARDS usually require mechanical ventilation with a higher than normal airway pressure. * PATHOPHYSIOLOGY ARDS Occurs as a result of inflammatory trigger that initiates the release of cellular and chemical mediators‚ causing injury to the alveolar capillary membrane. These result in leakage of fluid into the alveolar interstitial spaces and alterations
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Breathlessness 1. Presenting condition (PC) = Increase SOB 2. History of presenting condition (HPC) = Gradual decline or sudden. Any changes or normal exercise tolerance. Sleep at night‚ does lying flat make it worse? What makes it better/worse? 3. Past Medical History (PMH) 4. Drug History 5. Social History – include smoking‚ family history ect. 6. Examination of patient O – onset L – Location D – Duration C – Character A – Aggrevating R – Relieving T - Treatment TAKING A HISTORY Started
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the mortality rate is 35% to 40% and the cause of death is frequently due to nonrespiratory problems. ETIOLOGY The most common clinical problems associated with the onset of ALI and ARDS are sepsis‚ severe trauma‚ multiple transfusions‚ aspiration‚ severe pneumonia‚ and smoke inhalation. PATHOPHYSIOLOGY ARDS affects lung mechanics‚ gas exchange‚ and the pulmonary vasculature of both lungs. Although both lungs are affected‚ the degree of lung involvement varies throughout each lung. Alveolar
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