Neurodegenerative Disorders: Alzheimer’s Disease 1. Amyloid Precursor Protein (APP) Alzheimer’s disease (AD) remains a major cause of senile dementia‚ which is characterised by an impairment of neuronal and synaptic function in addition to the accumulation of β-amyloid plaque and formation of neurofibrillary tangles within distinct portions of the brain (De Strooper and Annaert‚ 2000). Progression of this distinct pathology of neurodegeneration does not typically vary from patient to patient
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elements by heating nitrogen‚ oxygen and chlorine gas at 400°C: N2 + O2 + Cl2 → 2ClNO Faraday obtained nitrosyl chloride by dissolving palladium in a mixture of hydrochloric and nitric acids (Faraday‚ M. Trans. Roy. Soc. (London)‚ Vol. 136‚ pp. 48‚ 1846): Pd + HNO3 + 3HCl → PdCl2 + ClNO + 2H2O Reactions Nitrosyl chloride undergoes addition reactions with many unsaturated organic compounds. It adds to olefinic double bond as follows: HC=CH— + Cl—N=O → ClCHCHNO For
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HEALTH SERVICES MINISTRY OF HEALTH & FAMILY WELFARE GOVT. OF INDIA‚ NOVEMBER 2010 Page 1 of 110 GUIDELINES ON COMMON TECHNICAL DOCUMENT (CTD) 28.10.2010 1 ABBREVIATIONS API BA BE CD CDSCO CPP CTD FSC GMP ICH ICMJE INR iv MA NDA NRA OCR PD PK po QOS WHO Active Pharmaceutical Ingredient Bioavailability Bioequivalence Compact Disc Central Drugs Standard Control Organization Certificate of Pharmaceutical Product Common Technical Document Free Sale Certificate Good Manufacturing Practices
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became a decentralized sales organization (marketing companies in 14 European countries‚ China‚ Brazil‚ and Australia.). It had a shared leadership with transfer of overseas assets to two trusts by late 1930’s. The organization was split to NOs and PDs. The independent NO’s great advantage was ability to sense and respond to the differences and Product development became a function of local market conditions. Research function remained independent with 8 more labs were set up
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1. OUR ANCESTRAL SOCIETY 1. a. Barangay 2. b. Classes: 2. b. 1. Datu or Sultan-dispose 2. b. 2. Maharlika or Freeman 2. b. 3. Alipin 2.b.3.a. Alipin Namamahay 2.b.c.b. Alipin Saguiguilid 2. ROOTS OF OUR AGRARIAN PROBLEM 2.a. 1565 – Miguel Lopez de Legazpi and Urdaneta – First Spanish settlement in Cebu 2.a.1.They decided to move to Manila for two reasons: 2.a.1.a. – Pintados
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Erika Mae R. Sia Group No: 4B “Wastes into Gold?” Philippine archipelago is genuinely rich with natural resources however‚ the country is still experiencing crisis for sustainable and affordable renewable energy sources – hydro‚ geothermal‚ wind‚ solar and biomass. Instead of developing these sources‚ humans tend to damage and deteriorate the environment due to misuse
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the book of beginnings. It tells the story of the beginning of the human race‚ in general and the beginning of the Hebrew race. The Hebrew Bible titles the book bereshith (“in the beginning”) The Author: Moses‚ and the Recipients: Israelites‚ Date: 1445 BC. (“In the beginning God created the heavens and the earth” Gen 1:1) Genesis introduces God is an absolute personal being who cares about his creation and the human struggle of the fallen world. God speaks‚ creates‚ calls‚ blesses‚ promises‚ and
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that there are normal personality traits underlying abnormal personality traits in people who exhibit dysfunctional personalities. Recently‚ scholars have begun to make an argument that current category systems of personality disorders (PDs) should be substituted by trait dimensional scheme designations in the
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work-related values Individualism / collectivism Low / High Power Distance Weak / Strong Uncertainty Avoidance Masculinity / Femininity (Mas – tough‚ value of success‚ money; Fem – tender‚ personal relationship‚ care) The Chinese Value Survey – PD‚ Ind vs Col. Mas vs Fem / Confuciansim High Confucian = long-term orientation (future concern and value thrift and persistence) JAP Low Confucian = short-term orientation (past / present‚ respect for tradition and social obligation) US Schwartz’s
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Catalysis: Midterm Review LECTURE 1: Sept 6th 2012 What is catalysis‚ Importance of catalysis‚ Industrial relevance‚ presentation of the course What is Catalysis: Catalyst: * catalyst is substance that increases the rate at which a chemical reaction approaches equilibrium‚ but is not consumed in the process * not reagent or product; noted above equation arrow * participates in kinetic equations‚ but not in eq constant Catalytic Cycle: * succession of chemical changes
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