My interest in liaison with Regulatory affairs started with the basics of subjects in my bachelor degree like Pharmacy Administration‚ Forensic Pharmacy‚ et.‚ and also some regulations included in subjects like Biopharmaceutics &pharmacokinetics‚ and Dosage Form Design. Regulatory affairs management has become essential in today’s pharmaceutical industry. It encompasses current science practices with legal and business issues. In this era of drug development and clinical trials‚ there
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development process and add an additional dimension to differentiate different members of a particular antibiotic class. To accomplish the goal of optimising the particular drug‚ from my understanding‚ the clinician must become familiar with the pharmacokinetic and pharmacodynamic concepts‚ as the understanding of these concepts establishes the basis for suitable dosing strategies. From what I have learnt in this module‚ the effort put into trying to grasp these concepts‚ in the context of drug usage
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PressReleasePing Concept Life Sciences acquires CXR Biosciences to augment its expanding service base in Discovery and PreClinical Sciences LONDON: Concept Life Sciences‚ scientific Laboratory and consultancy group has acquired CXR Biosciences. This marks its fourth acquisition since it was formed in July 2014. Led by Executive Chairman Michael Fort and Chief Executive Officer Alan Morgan the Concept Life Sciences Group currently has over 600 staff in 11 core locations‚ with advanced plans for further
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CNPR® Certification Exam 13th and 14th Edition Directions: The timer will be viewable throughout your exam at the bottom left of the page. Once your time is up the exam will submit your answers‚ so please make sure you answer each questions before you run out of time. PLEASE WRITE DOWN THE ANSWERS ON PAPER IN CASE OF SUBMISSION ERROR. Name: Carmen Littleton Email: cml0029@auburn.edu 1. How are drugs sorted into therapeutic groups and classes? 1. first by the conditions that they are used to treat
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Mycobacterium spp. ciprofloxacin is active against bacteria producing beta-lactamases. Ureaplasma urealyticum‚ Clostridium difficile‚ Nocardia asteroides resistant to ciprofloxacin. The effect on Treponema pallidum is studied not enough. Pharmacokinetics Rapidly absorbed from the gastrointestinal tract. Bioavailability after oral administration of 70%. Eating has a little effect on the absorption of ciprofloxacin. Plasma protein binding is 20-40%. Distributed in tissues and body fluids. It penetrates
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Furness‚ P.‚ Johnson‚ T.‚ Rostami-Hodjegan‚ A.‚ & Soltani‚ H. (2012). Anatomical‚ Physiological and Metabolic Changes With Gestational Age During Normal Pregnancy: A Database for Parameters Required in Physiologically Based Pharmacokinetic Modelling. Clinical Pharmacokinetics‚ 51(6)‚ 365-396. Avery‚ A. A.‚ & Brown‚ A. A. (2012). Healthy Weight Management During Pregnancy: What Advice and Information is Being Provided. Journal Of Human Nutrition & Dietetics‚ 25(4)‚ 378-387. Jarvis‚ C. (2012). Physical
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Table 3 ADMET Pharmacokinetic properties Ligant Compound Name Solubility BBB CYP2D6 Absorbtion Hepatotoxic AlogP98 PSA_2D level Level Level 2-nitro-3-phenyl-3- 6a (phenylthio)propan- 3 2 -0.956743 0 -1.19046 3.633 63.638 1-ol 3-(4-ethylphenyl)-2- 6b nitro-3- 2 1 -1.21276 0 -0.792508 4.576 63.638 (phenylthio)propan- 1-ol 3-(4- methoxyphenyl)-2- 6c nitro-3- 2 2 -2.05551 0 0.0841152 3.617 72.568 (phenylthio)propan-
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Simvastatin Medicine Simvastatin is lipid lowering drug with a chemical formal of C25h38O5 and has a molecular weight of 418.57and a melting point of 135-138 °C . Their high efficacy has led to increased usage in reduction of cholesterol on the blood and as treatment measure of choice. The Chemical Structure and Functional Groups of Simvastatin The Mode of Action of the Drug Simvastatin belongs to a class of drugs referred us statins which are 3-hydroxy-3-3methylglutaryl coenzyme A reductase
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The purpose of the study was to design a suitable Transdermal therapeutic system for Venlafaxine Hcl (VFH) with the objective to prolong the release to be used for controlled release drug delivery.Transdermal patches of VFH with a HPMC-drug reservoir were prepared by the solvent evaporation technique. In this investigation‚ theEudragit RSPO membrane in different concentrations was cast to achieve controlled release of the drug. The absence of physiochemical interactions between VFH and the polymers
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Andrew Knight describes a list of ways around animal testing‚ ways that are better and more correct. A few ways he describes are: “Pharmacokinetic (PK) models predict in-vivo concentrations of test substances and metabolites‚ and the organ systems affected (Combes et al‚ 2007)‚”‚ “[Assays reliant on bacterial‚ yeast‚ protozoan‚ mammalian or human cell cultures] may be static or perfused
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