nM‚ +. The estimated activities by Hypo1 pharmacophore model and experimental activities of 21 training set compounds presented in Table 1. The error value is calculated by the ratio between the estimated and experimental activities. The negative error value indicates that the estimated IC50 value is lower than the experimental activity whereas‚ the positive error value indicates that the estimated IC50 value is higher than
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Pharmacophore development for identification of anti-lung cancer drugs Pharmacophore development for identification of anti-lung cancer drugs Sadia Abbasi a‚*‚ Shanila Emmanuel a‚ Muhammad Haseeba‚ Aftab Khalil a‚ Saima Kulsoom b‚ Hamid Rashid a‚ Raisa Bano a a b Department of Bioinformatics‚ Mohammad Ali Jinnah University‚ Islamabad‚ Pakistan Department of Chemistry‚ Quiad-e-Azam University‚ Pakistan Lung cancer is one particular type of cancer that is more deadly and common than
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neurodegenerative effects. In an attempt to further diverse treatment options for patients currently suffering from Alzheimer’s‚ novel protein receptors in the brain are being examined. Additionally‚ by identifying the structural motifs that define the pharmacophores of molecules which appear to aid in Alzheimer’s
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Chagas disease is a public health problem in Latin America with a great impact in Brazil. The latest estimates show that about seven million people in the world are infected by the kinetoplastid protozoa Trypanosoma cruzi (1). In spite of this‚ there are no vaccines against Chagas Disease (2). The current drugs used for treating this disease are effective only in the acute phase‚ with limited efficacy in the chronic stage of the disease and many toxic side effects (3) (4). Therefore‚ there is
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It is somewhat ironic to discover that the pharmacophore of phosphoramide drugs currently used as antitumor agents was originally utilized for the purpose of chemical warfare‚ most prominently so in World War I. Sulfur mustard‚ the precursor to phosphoramide drugs‚ was employed to great effect as a wounding agent in the characteristic trench warfare of WWI; Being a dense gas‚ sulfur mustard settled in trenches and created persistent environmental hazards for troops. Exposure to sulfur mustard‚
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Mr.Venkatesh Jangala Phone: +91 9985398963 Email: venky.jangala@gmail.com Date of Birth: 23 november 1987 Address: D.NO; 3-578(A)‚Undavalli centre‚ Tadepalli(post)‚ Gunturdist - 522501. Languages Known: English‚ Hindi‚ Telugu Objective: To be a part of an organization where my skills are put to an optimal use and which offers scope for knowledge and growth. Educational Qualifications: |Year |Degree/Certificate |University/Board
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(2-acetyl) benzimidazole have been exhibited good activity in the dose of 20 mg/ml against earth worm‚ bacteria and fungi like standard drug. This may be due to presence acetyl moiety in the benzimidazole ring conjugated with quinoxaline-2‚ 3- dione pharmacophore
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Contents 1.0 Abstract Acetaminophen and aspirin are both well-known drugs that relieve pain and reduce fever. This report looks at acetaminophen as a potential substitute for a patient who is allergic to aspirin. Acetaminophen‚ a common analgesic drug that can be bought over the counter‚ was synthesised by Hormon Northrop Morse. With acetaminophen consisting of a benzene ring‚ an amide and an alcohol group‚ it has the ability to stop pain and reduce fevers. However‚ due to the state of technology
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Current Medicinal Chemistry‚ 2011‚ 18‚ 733-766 733 New Lead Structures in Antifungal Drug Discovery Chunquan Sheng and Wannian Zhang* Department of Medicinal Chemistry‚ School of Pharmacy‚ Second Military Medical University‚ 325 Guohe Road‚ Shanghai 200433‚ People’s Republic of China Abstract: During the past two decades‚ the incidence of invasive fungal infections has been increasing dramatically. Clinical available antifungal agents have several drawbacks such as limited potency and
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like India with a large agricultural base. The vast and varied flora and fauna found thriving in the widely diverse geographical and climatic conditions of India constitute a rich source of potentially bioactive metabolites containing diverse pharmacophores
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