procedure were benzophenone‚ malonic acid‚ and biphenyl. These three solids were then mixed with water (highly polar)‚ methyl alcohol (intermediately polar)‚ and hexanes (nonpolar). When benzophenone is mixed with water the results turned out to be insoluble because benzophenone is a pure hydrocarbon‚ which are very insoluble in water. When benzophenone was mixed with methyl alcohol‚ it was soluble because Methanol can hydrogen bond to the carbonyl oxygen of benzophenone. When benzophenone was added to
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From here‚ the refluxing began and ended once the bromobenzene addition was completed. The second phase of the experiment involved the reaction of the phenylmagnesium bromide with assigned carbonyl compound. Appropriate amounts of benzaldehyde‚ benzophenone‚ or methyl benzoate based on the amount of bromobenzene used should be added to a dry beaker along with anhydrous diethyl ether. The mixture was poured into the addition funnel‚ added to round bottom flask drop wise‚ allowed to reflux for an additional
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| Reactions of Grignard Reagents with Carbonyls | | | Tuesday 1:30 | 2/28/2012 | | Introduction This experiment explores the reactivity pattern for the addition of Grignard reagents to three different carbonyl groups: a ketone‚ an ester‚ and a carbonate. Grignard reagents are organometallic compounds that have a carbon-metal bond‚ such as carbon-magnesium. Grignard reagents are formed from the reaction of an alkyl‚ cycloalkyl‚ or aryl halide and magnesium metal in dry ether
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n.p.‚ n.d. Sigma Aldrich. Sigma Aldrich. Web. 14 Oct. 2012. <www.sigmaaldrich.com>. 6MSDS. Rep. no. B4856. N.p.: n.p.‚ n.d. Sigma Aldrich. Sigma Aldrich. Web. 14 Oct. 2012. <www.sigmaaldrich.com>. Benzhydrol can be synthesized from Benzophenone via a reduction reaction. Samples of the reaction mixture are taken at several times during the reaction (start‚ 50% of the way and at the end of the reaction time). Draw the anticipated results (spots) for silica gel TLC plates at the specified
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1) Results in table form Solvent: Solvent: Solvent: methanol Solid Organic Molecules water hexane (intermediate (highly polar) (nonpolar) polarity) Benzophenone Soluble after O Partially Completely 20 seconds soluble after soluble after without C 60 seconds 20 seconds mixing Succinic Acid Insoluble O after
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Abstract: The purpose of this lab was to synthesize triphenylmethanol from benzophenone and bromobenzene by the formation of a Grignard compound with the reagents bromobenzene and magnesium metal. The bromobenzene was first transformed into the Grignard compound and was then reacted with the benzophenone to make the final product. The mixture was then mixed with sulfuric acid and the organic layer was extracted via a separatory funnel. The mixture was then recrystallized from methanol and was allowed
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observe the various melting points of Naphthalene and Biphenyl when the percentage of composition was altered. A eutectic point of 45 °C at 52% Naphthalene was determined from the class data. An unknown crystalline substance was identified to be Benzophenone by mixing and finding its melting point with known substances. Introduction Organic compounds are categorized by their physical properties and/or chemical reactions. Naphthalene is classified as an aromatic hydrocarbon that consists
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Lab #1 Extraction and Thin Layer Chromatography Kaya Gaudet 6784928 January 9‚ 2013 Line Structure References BenzophenoneBiphenylBenzoic Acid Extraction: A process used to separate different compounds in a mixture based on their solubility in an immiscible substance. Usually an aqueous and organic phase are used. During extraction the desired compound moves one phase and leaves the unwanted substance behind. Extraction normally has to be done a few times to leave all of the impurities
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compound called benzophenone‚ as well as additional ether. The end product of triphenylmethanol was analyzed via NMR and IR. Figure 1: Preparation of the Grignard agent by combining bromobenzene with magnesium and ether to produce phenylmagnesium bromide. Figure 2: Production of triphenylmethanol by combining benzophenone and the Grignard reagent. Introduction Grignard reagents are important due to their ability to form carbon-carbon bonds through conversion of a ketone (benzophenone) into an alcohol
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Questions: 1. Write a mechanism for the Grignard reaction of benzophenone with phenylmagnesium bromide. Be as complete as possible and show electron flow for all steps. 2. Explain the special role of ethereal solvents like diethyl ether in the formation of Grignard reagents. 3. Triphenylmethanol can be prepared from phenylmagnesium bromide via several different Grignard reactions. Identify two other electrophiles (aside from benzophenone) that will react with PhMgBr to produce triphenylmethanol
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