to reduce swelling‚ soreness‚ and redness (an anti-inflammatory agent). Much of this is believed to be due to decreased production of prostaglandins and thromboxanes. Aspirin’s ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX) enzyme. Cyclooxygenase is required for prostaglandin and thromboxane synthesis. Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the
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Products as Inhibitors of Prostaglandin Biosynthesis Ylva Noreen‚† Therese Ringbom‚† Premila Perera‚† Helena Danielson‚‡ and Lars Bohlin*‚† Division of Pharmacognosy‚ Department of Pharmacy‚ Biomedical Centre‚ Uppsala University‚ Box 579‚ S-751 23 Uppsala‚ Sweden‚ and Department of Biochemistry‚ Biomedical Centre‚ Uppsala University‚ Box 576‚ S-751 23 Uppsala‚ Sweden Received July 18‚ 1997X A radiochemical enzyme assay for studying cyclooxygenase (COX)-catalyzed prostaglandin biosynthesis in vitro
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involves oral mifepristone‚ a progestin antagonist which sensitises the myometrium to prostaglandin induced contractions and ripens the cervix‚ followed by misoprostol‚ a synthetic prostaglandin analogue‚ orally and or vaginally‚ which causes uterine contractions and cervical dilatation. The addition of the progesterone antagonist reduces the induction to abortion interval‚ analgesia required and prostaglandin dose(Farquhar et al. 2009 pg.1). A surgical termination consists of prior dilapan rod insertion
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have effective in inhibitory activities against a wide range of enzymes like protein kinase C‚ protein tyrosine kinase‚ phospholipase A2. Certain glycosides effectually inhibit prostaglandins‚ a collection of pro-inflammatory signalling molecules. This is chiefly due to inhibition of certain enzymes participating in prostaglandin biosynthesis such as lipoxygenase‚ phospholipase and cycloxygenase. Inhibition of these enzymes by glycosides inhibits the inflammatory process (George and Joseph‚ 2010). Below
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G Model JMG-5899; No of Pages 17 Journal of Molecular Graphics and Modelling xxx (2009) xxx–xxx Contents lists available at ScienceDirect Journal of Molecular Graphics and Modelling journal homepage: www.elsevier.com/locate/JMGM Genome wide analysis and comparative docking studies of new diaryl furan derivatives against human cyclooxygenase-2‚ lipoxygenase‚ thromboxane synthase and prostacyclin synthase enzymes involved in inflammatory pathway P. Nataraj Sekhar a‚ L. Ananda Reddy a
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Prostaglandin E2 EP3 receptor regulates cyclooxygenase-2 expression in the kidney Carlos P. Vio‚ Mariana Quiroz-Munoz‚ Catherina A. Cuevas‚ Carlos Cespedes and Nicholas R. Ferreri Am J Physiol Renal Physiol 303:F449-F457‚ 2012. First published 23 May 2012; doi: 10.1152/ajprenal.00634.2011 You might find this additional info useful... This article cites 55 articles‚ 29 of which you can access for free at: http://ajprenal.physiology.org/content/303/3/F449.full#ref-list-1 This article has been cited
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Aspirin or acetylsalicylate acid is a compound that is widely used in medicine. The use of aspirin in medicine began long before the active reagent was removed from its natural source. The first documented use of aspirin was found in the writings of Hippocrates‚ the so called father of medicine. Hippocrates prescribed that willow bark could be used to remedy a wide range of conditions such as pain‚ fever and inflammation. Scientists began to seek to extract the active compound from willow tree bark
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and accumulation of high concentrations of toxins.1‚4 Intrarenal prostaglandin H synthase has been implicated as a contributing factor of ischemia.1‚2 Prostaglandin H synthase is responsible for the local production of vasodilators within the papillae – The papillae vascular supply is highly dependent and responsive to PGs functional role in the countercurrent multiplier concentrating system.1‚2 In the presence of NSAIDs prostaglandin H synthase is inhibited and vasoconstriction is then induced by
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Inflammation | * The succession of changes that occurs in a living‚ vascularized tissue when it receives a sublethal injury * Is designed to destroy‚ dilute‚ or otherwise inactivate the injurious agentIs designed to restore the tissue to its original state‚ insofar as possib | Acute Inflammation | Short durationAccumulation of neutrophils | Chronic Inflammation | Longer durationAccumulation of macrophages and lymphocytesProliferation of fibroblasts and blood vessels | Endothelial | Line
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Abortion is becoming a popular choice for most young women in America‚ but is it considered a crime‚ murder? Many women have abortions for example‚ because they are not ready or financially can’t have a baby at the time. But is that okay? Should they be considering the consequences that will come? This paper will strongly talk about abortion laws on the Untied States‚ abortion statistics throughout the world and United States‚ and how abortion is presently performed. Abortion laws are only individual
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