Pathologic Mechanisms of Septic Shock Kenneth J. Goodrum‚ Ph.D. OUCOM Topics ● ● ● ● ● ● ● Definitions: SIRS‚sepsis‚shock‚MODS Morbidity/mortality of Sepsis/Shock Pathogenesis of shock Microbial triggers(endotoxin‚ TSSTs) Cytokine and non-cytokine mediators of SIRS and shock Pathophysiology of shock Therapy Systemic Inflammatory Response Syndrome (SIRS) ● ● ● ● ● Systemic inflammatory response to a variety of severe clinical insults manifested by ≥ 2 of the following conditions
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Nociceptor (c) Photoreceptor (d) None of the above 3. Parkinson’s Disease is often treated with the administration of this substance from which dopamine is synthesized. 4. Name this neurological condition‚ deeply contributed to by the actions of prostaglandins‚ where innocuous stimuli may cause the feeling of pain. 5. The myelin sheath‚ which speeds the transmission of signals across the axon‚ is composed of these kind of cells in the Central Nervous System. 6. This disease‚ characterized by fatigue
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This enzyme is required for the synthesis of prostaglandins which regulate hormones‚ inflammation‚ and calcium movement. This creates the analgesic‚ and anti-inflammatory properties Pharmacokinetics: Absorption: "When absorbing‚ the peak plasma levels of celecoxib occur approximately 3 hrs after an
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What Can Your Period Tell About Your Health? Your period reveals a lot of information about your health. If you notice some unusual symptoms‚ such as pain‚ irregular flow‚ or a change of the color of your period‚ there may be something wrong with your health. Here are some period symptoms that will help you to identify whether you are dealing with some health problem. Period Pain While experiencing some small amount of pain during your period is a common issue‚ excessive pain that lasts for days
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non-steroidal anti-inflammatory drugs (NSAIDs) can erode the mucosal lining of the stomach as well. Investigators believe that NSAIDs can cause a gastric ulcer by inhibiting prostaglandins (the fatty acids that the stomach release which regulate acid secretion). Exposure to irritants like certain drugs and alcohol can also inhibit prostaglandin secretion in the stomach triggering a mechanism much like the one caused by NSAIDs. So‚ drinking too much
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Administering Medication to Individuals and Monitoring the Effects The Care and Social Services Inspectorate Wales (CSSIW) are the regulatory body that provide us with standards that are expected of us when administrating medication. Under The Medicines Act 1968‚ which is a major piece of legislation‚ governs the responsibility we have in administering medication to our clients. There are three important statements from this piece of legislation‚ which are: Medicines prescribed to a person are that
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interneurons and motor neurons in the central nervous system. These provide more control over the digestive and glandular activates. Hormonal process’ involve about 18 hormones‚ each affecting digestive functioning. Local mechanisms involve prostaglandins‚ histmins‚ and other chemicals that are released into the interstitial
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reteric colic represent one of the common medical problem encountered by urologists in the emergency room‚ they are usually caused by ureteral stones. Management of such condition is usually conservative at first‚ if the stone fail to pass a more prompt action is needed‚ which is usually by one of the minimally invasive procedures like extracorporeal shockwave lithotripsy (ESWL)‚ ureteroscopy‚ or percutaneous nephrolithotomy‚ depending on the stone size‚ location and the presence and degree of associated
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Natasha Palmer PHI-105 Professor Denney 11/24/2011 Abortion Persuasive Essay Abortion may be one of the easiest ways to fix a mistake‚ but no way ground for killing a baby. My opinion is if you are going to have sex and take a chance of getting pregnant‚ then why not step up and enjoy the best blessing you will ever encounter? Abortion happens every day‚ but so does joy when a child is born. In 1996‚ there were approximately 3‚700 abortions a day. (Facts about Mifepristone (RU-486). January
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Mediator | Source | Function | Vasoactive amines | Histamine | Mast cells‚ basophil‚ platelet | Vasodilation‚ ↑ vascular permeability‚ endothelial activation | Serotonin | platelets | Vasodilation‚ ↑ vascular permeability | Eicosanoids | Prostaglandins | Mast cells‚ leukocytes | Vasodilation (PGD2‚PGE1‚E2 & PGF2-α)‚ pain (PGE2)‚ fever | Thromboxane A2 | | Promotes platelet aggregation‚ vasoconstriction | Prostacyclin | | Inhibits platelet aggregation‚ vasodilation | Leukotrienes
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