Compare and contrast tumour suppressor genes and proto-oncogenes. Discuss an example of how recent advances in our understanding of these genes have led to the development of a novel therapy that is being used in the treatment of human cancer. Cancer known in medicine as a malignant neoplasm is one of the biggest killers worldwide. In 2007‚ cancer caused roughly 13% (7.9 million) of the planet’s deaths (Jemal‚ 2011). This will more greatly affect an aging society such as ours in years to come‚ and
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Amajala et al Journal of Drug Delivery & Therapeutics; 2012‚ 2(4)‚ 85-89 85 Available online at http://jddtonline.info RESEARCH ARTICLE METHYLATION PROFILING OF TUMOR SUPPRESSOR GENES INVOLVED IN LUNG CANCER * Krishna Chaitanya Amajala‚ Vishwanath A‚ Kaladhar DSVGK and Bhaskar Reddy I Department of Bioinformatics & Biochemistry‚ GITAM Institute of Science‚ GITAM University‚ Visakhapatnam-530045‚ Andhra Pradesh‚ India *Corresponding author’s Mail: chy2ak@gmail.com Received
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Contents Oncogene An oncogene is a kind of abnormal gene that predisposes cells to develop into cancers. Unlike normal genes‚ which can be turned off after being turned on‚ oncogenes are altered in a way that keeps them stuck in a state of constant activity. That uninterrupted action helps drive the uncontrolled growth that underlies tumors. Oncogenes can be turned on by inherited changes - ones that are passed down from parent to child - or by cancer-promoting agents that
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is a tumor suppressor gene‚ which usually stops cell division from occurring. This gene is very important during the G1/S checkpoint because it stops cell division from occurring if damaged or dangerous genetic material (DNA) is found. It then signals for enzymes‚ which are used to repair the damaged component of the DNA‚ which then allows cells with repaired DNA to divide. When DNA can’t be repaired‚ then the cell goes under apoptosis (death of the cell). However when this gene is turned off
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FASHION MERCHANDISING Orient Craft Limited‚ Manesar Proto Tech Pack Assessment By Under the guidance of V. Priyadarshini Associate Professor DFT Akhil Tyagi (2) Haqiqat Ali (12) Md. Jawed Akhtar (15) Sumit Sinha (27) DFT - 5 Introduction Established in 1978 One of the largest Export House in India Turnover of around 725 crores Deal with US and European buyers 21 manufacturing units in and around Delhi . strength of 25000 workers. Major clients- Tommy Hilfiger
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into sculpture through the Gothic style. The competition held in Florence for the execution of the east doors of the Baptistery‚ the Romanesque structure across from the cathedral where all Florentine citizens were baptized‚ marked the end of the Proto- Renaissance era on 1402.
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Argentine collector Eduardo Costantini for U$1.4 million‚ and it is currently displayed at the Latin American Art Museum of Buenos Aires (Museo de Arte Latinoamericano de Buenos Aires). “Abaporu” in Tupi-Guarani‚ one of the most significant indigenous proto-language in Brazil‚ signifies “the man that eats people”; since “abá” stands for man‚ “poro” is people‚ and “’u” means to eat. The artist used formal elements of the Surrealism to show the discrepancy between the ideals of the European Surrealism and
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My Genes made me do it! Consider the Genetic Influences on Criminal Behaviour. My Genes made me do it! Consider the Genetic Influences on Criminal Behaviour. A gene is a sequence on DNA that has a specific region on the chromosome‚ which determines a particular characteristic in an organism. For many years it has been thought that there are specific genes responsible for certain behaviour and so there is a gene for criminal behaviour. In the first half of the twentieth century
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Renaissance kicked off called Proto-Renaissance‚ and the factors contributing to its success. The three factors that contributed to the success of this transition were‚ where it began‚ the influence of humanism‚ and artistic innovations contributed by artists. These factors are considered to be essential in the new coming artistic style of naturalism. The origins of Renaissance art can be traced to Italy in the late 13th and early 14th centuries. During this period called “Proto-Renaissance‚” sometimes
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Cancer Gene Detection 11/06/12 Laboratory Report Objective(s) – The purpose of this experiment is to help students gain an understanding of p53 tumor suppressor genes and its role in familial cancers. Also‚ we evaluated p53 in cancer. Hypothesis – If the DNA has bits and particles‚ which are p53 hotspots being cut‚ than that means that cancer has been detected. Techniques & Skills – The skills that are required for this laboratory experiment is that we must exercise extreme caution when
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