Information. The p53 Tumor Suppressor Protein. 2008. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gnd&part=thep53tumorsuppressorprotein (accessed 11 19‚ 2010). 7. GeneCards. Suppressor of Cytokine Signaling 1. 2009. http://www.genecards.org/cgi-bin/carddisp.pl?gene=Socs1 (accessed November 10‚ 2010). 8. GenWay. SOCS1 Anitbody. 2010. http://www.genwaybio.com/product_info.php?products_id=43725 (accessed November 20‚ 2010). 10. University of Arkansas for Medical Sciences. Gene Expression Signatures
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Cancer Right now‚ cancer is one of the most feared diseases in the world. In the early 1990s almost 6 million new cancer cases developed and more than 4 million deaths from cancers occurred. Also more than one-fifth of all deaths were caused by cancer and it has been predicted‚ by the American Cancer Society‚ that about 33% of Americans will eventually develop this disease. This is a huge disease that is killing people all over the world. The field of cancer study is called Oncology. The government
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formation and development of proto-Japanese language and the proto-Japanese nation also has two periods. In the Yayoi period‚ Korean people migrant from the Korean Peninsula to Japan‚ but the Korean immigrants did not replace the Jomon people who live in the mainland Japan‚ only part of the Korean intermarriage with the Jomon indigenous. On the Japanese nation aspect‚ according to Keiji Imamura’s research‚ “he found that the mainland Japanese are more similar to the Korean on the gene than the Ainu and Ryukyuans
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adult females. Devils once occurred on mainland Australia‚ but have been confined to Tasmania since pre-European times. The survival of Tasmanian Devils is threatened by Devil Facial Tumour Disease (DFTD)‚ and the species is now listed as Endangered. Devil facial tumour disease emerged in 1996 and causes tumours around in and around the mouth‚ face and neck and sometimes other parts of the Devils. The disease develops rapidly and is fatal: affected animals die within six months of the lesions
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Given the potential dangers of nanotechnology‚ should it be used to lightweight sports equipment? Nanotechnology has an array of uses‚ from sunscreen to sporting equipment. Sports equipment has been vastly innovated by the discovery and application of nanotechnology in recent years. The highest end tennis racquets‚ baseball bats and even racing bicycles all use nanotechnology to combine strength and lightness provided by this technology. Some of the bicycles made with nanotechnology are priced at
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responsible gene to destroy or recycle the damaged cells at the checkpoint is called the tumor suppressor genes. There are many known tumor suppressor genes; the first one discovered by human is Retinoblastoma but the most renowned one is p53. In the damaged cells‚ however‚ the tumor suppressor genes are turned off by mutation‚ which may change‚ add or delete some of the alleles in the genes‚ as a result‚ the gene cannot function in proper manner. In the absence of the tumor suppressor genes‚ damaged
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Testicular cancer involves the malignant transformation of normal gonocytes into germ cell tumours. It is the most common malignancy amongst men aged 15-35 years‚ and has a current cure rate of 90%‚ however incidence amongst Caucasian males is steadily rising.1 There are three main types: teratoma‚ usually neonates and children; seminoma/nonseminoma‚ occurs in men >15 years old; and spermatocytic seminoma which occurs in men >50 years old. Seminoma/nonseminoma are the most common‚ and only malignant
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1. Rosenburg N‚ Jolicoeur P: Retroviral pathogenesis. In In Retroviruses. Edited by Coffin JM‚ Hughes SH‚ Varmus HE. Cold Spring Harbor Laboratory Press; 1997::475-586. 2. Nowinski RC‚ Hays EF: Oncogenicity of AKR endogenous leukemia viruses. J Virol 1978‚ 27:13-18. PubMed Abstract | PubMed Central Full Text 3. Cloyd MW‚ Hartley JW‚ Rowe WP: Lymphomagenicity of recombinant mink cell focus-inducing murine leukemia viruses. J Exp Med 1980‚ 151:542-552. PubMed Abstract | Publisher Full Text 4
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have angiogenesis as an underlying mechanism grows longer every year. [1] The essential role of angiogenesis in tumour growth was first proposed in 1971 by Judah Folkman‚ who described tumours as "hot and bloody. Angiogenesis is a multi-step process recruited for the formation of new blood vessels is one of the crucial processes for the growth‚ survival‚ proliferation and metastasis of tumours. Under normal conditions angiogenesis is virtually essential for cell reproduction‚ development and wound healing
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Oncotarget‚ November‚ Vol.1‚ No 7 www.impactjournals.com/oncotarget/ Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells Joshua C. Curtin and Matthew V. Lorenzi 1 Oncology Drug Discovery‚ Research and Development‚ Bristol-Myers Squibb‚ Princeton‚ NJ‚ USA Correspondence to: Matthew V. Lorenzi‚ e-mail: Matthew.Lorenzi@bms.com Keywords: oncotarget‚ cancer‚ stem cells‚ wnt‚ drug discovery Received: August 8‚ 2010‚ Accepted: October 27‚ 2010‚ Published: October 30‚
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