THE FRIEDEL-CRAFTS REACTION: ACETYLATION OF FERROCENE Ferrocene was acetylated in acetic anhydride and phosphoric acid. It proceeded via a Friedel-Crafts reaction without the use of organic solvents or strong Lewis acid. Operations and Observations A mixture of ferrocene (1.5 g‚ 0.008 mol)‚ acetic anhydride (5 mL) and phosphoric acid (1 mL 85%) was heated over a steam bath until all the ferrocene dissolved and the mixture darkened from orange to dark red. The mixture was then refluxed with
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Lab 6: Electrophilic Aromatic Substitution(1) Nitration of Methyl Benzoate(2) Synthesis of 1‚4-Di-t-butyl-2‚5-dimethoxybenzene byFriedel-Crafts Alkylation of 1‚4-DimethoxybenzenePurpose1)To carry out the nitration of methyl benzoate‚ and then identify the major product formed (position at which nitro-group substitution takes place) by thin-layer chromatography (TLC)‚ the percent yield and the melting point range. 2)To synthesize 1‚4-Di-t-butyl-2‚5-dimethoxybenzene by Friedel-Crafts Alkylation of
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Zhang Monday 1PM 2/10/14 & 2/24/14 - Abstract A sample of triphenylmethanol was prepared using Grignard synthesis techniques. Reflux was used in order to speed up the reaction and the final product was purified using recrystallization methods. The percent recovery and percent yield were 80.46% and 47.526%‚ respectively. A melting point range of 85-87oC was obtained from the purified product. - Introduction A Grignard reaction adds an alkyl-magnesium halide to an aldehyde
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Experiment 1: Mechanism of Nitrile Oxide and Alkene Cycloaddition 1. Purpose: to clarify the mechanism for the cycloaddition reaction between benzonitrile oxide and an alkene‚ and to test the regiochemistry of the reaction between benzonitrile oxide and styrene. 2. Plan: Each student in a group of three will work to create a reaction with the Benzonitrile Oxide with‚ cis-stilbene‚ trans-stilbene‚ or styrene in an Erlenmyer flask. With this Reaction solution thin layer chromatography will be
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Aspirin Synthesis Introduction Out of all the pharmaceutical drugs in the worlds‚ aspirin is made the most. Any potential pharmacist must be familiar with synthesizing the drug. The goal of this lab is to synthesize as much pure aspirin as possible. The reactants‚ acetyl anhydride and salicylic acid‚ must react in phosphoric acid. With phosphoric acid as a catalyst‚ the reaction yields aspirin and acetic acid. The equation for the reaction is as follows: “(CH3CO)2O + HOC6H4COOH □(→┴yields ) CH3CO2C6H4CO2H
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AIMS At the end of the experiment‚ students should be able to synthesise pure aspirin using chemical tests such as esterification and recrystallization independently and to also find out the melting point range of aspirin using melting point determination. INTRODUCTION Aspirin‚ which is also known as acetylsalicylic acid‚ is one of the commonly used and widely found in any drugstore or pharmacy. Its properties make aspirin a well-rounded drug that reduces inflammation and fever and also relieves
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Sypnopsis In this experiment‚ acetylsalicylic acid was synthesized from the acidification of salicylic acid and acetic anhydride. The objective was to convert a specific amount of salicylic acid into the same amount of aspirin that was high in purity. Furthermore‚ the other objectives were to enable students to conduct the synthesis of aspirin‚ reinforce skills or recrystallisation and the technique of melting point determination. The amount of each compound should be the same because there is
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point of the compound was determined afterwards. The solid yield (neutral component) was purified by recrystallization by using ethanol as the solvent. ~20 mL of ethanol was added to the solid. Water was then added to this solution drop wise until the solution turned cloudy. After that‚ ethanol was added drop wise again until the solution appeared clear again. To faster the recrystallization‚ the solution was put in an ice bath. The yield was then collected by suction filtration. The weight and
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the first step in the lithification process. There are several ways that this can happen. The other two ways that this can happen is through cementation or recrystallization. Cementation is the process in which substances dissolve in pore water precipitates out and forms a matrix in which grains of sediment are joined together. Recrystallization is the process where the formation of new crystalline mineral grains from old ones. (Murck‚ et al.‚ 2008) Types of Sedimentary Rocks When clastic sediment
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Toxic Water Used to destroy acetic anhydride which did not react; precipitates crude aspirin colorless liquid Molar Mass: 18.06 g/mol Melting Point: 0 °C Boiling Point: 100 0C Density: 1.0g/cm3 -------------- Diethyl ether Recrystallization solvent colorless liquid with a sweet‚ characteristic smell Molar Mass: 74.12 g/mol Melting Point: - 116°C Boiling Point: 35 0C Density: 0.7134 g/cm3 Easily ignited‚ Harmful by ingestion‚ inhalation or through skin contact. Petroleum
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