We performed two procedures in which we reduced methyl acetoacetate. For the first procedure we produced a racemic mixture of Methyl (S)-3-Hydroxyacetate and Methyl (R)-3-Hydroxyacetate. For the second we produced only one of the enantiomer products depending on which enantiomer of Tartaric Acid was used. A reduction is a reaction which generally means adding more carbon-hydrogen bonds to a compound. In a reduction reaction the oxidation number of a carbon atom decreases. The opposite is an oxidation
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8-dibromo-2-(4-chlorophenyl)quinazolin-4-yloxy)methyl)-5-methyl-1‚3‚4-oxadiazole (IX) : A mixture of the hydrazide VII (0.01 mol) and acetic anhydride (30mL) was refluxed for 6h. The precipitated solid formed upon cooling‚ was filtered and recrystallized from ethanol‚ m.p. 155oC‚ 80% yield. Analysis calculated for C18H11Br2ClN4O2; Calcd.: %C‚ 42.34; H‚ 2.17; N‚ 10.97‚ Found: % C‚ 42.30; H‚ 2.14; N‚ 10.90. IR: υmax./cm-1 3000 (C-H aromatic)‚ 1610 (C=N) and at 1600 (C=C). 1H-NMR (DMSO-d6‚ ppm): δ 2.6 (s‚ 3H‚ CH3)‚ 5.4 (s‚ 2H‚ OCH2) and
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Recrystallization of Methyl 3-nitrobenzoate Santiago Horta‚ Daniella I School of Chemistry and Biochemistry‚ Georgia Institute of Technology Atlanta‚ GA 30332 Submitted: 18 February 2015 In this experiment‚ the product of a nitration will be purified by recrystallization using a selected solvent. Methyl benzoate is treated with nitric acid and sulfuric acid to obtain methyl 3-benzoate‚ which will be mixed with a solvent that will dissolve the product at its boiling temperature but not at
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Title: Experiment 28: Nitration of Methyl Benzoate Objective: The students will learn to nitrate methyl benzoate through electrophilic aromatic substitution reaction. They will learn the importance of regiochemistry in chemical reactions. They might experience disubstitution through a high temperature. Reactions: Observation: The crystals started to form when added 2 g of crushed ice. The addition of hot methanol dissociated the crystals. The crystals reappeared when cooled down in
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Preparation of methyl m-nitrobenzoate by nitration using methyl benzoate‚ nitric acid‚ and sulfuric acid Aileen Quintana TA: Sijie Tues/Thurs 11:50 42067 Introduction: The purpose of this lab was to explore the concepts of electrophilic aromatic substitution‚ specifically nitration by synthesizing methyl m-nitrobenzoate using methyl benzoate‚ nitric acid and sulfuric acid. This nitration is a type of electrophilic aromatic substitution. A
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ABSTRACT This experiment was conducted to synthesize methyl benzoate form benzoic acid and methanol by using the Fischer esterification method. The Fischer exterification technique is utilized in the academic and industrial settings due to the simplified synthesis and safety parameters of the overall reaction. Both benzoic acid and methanol are relatively cheap to obtain from a commercial source as well as being easy to store with a relatively long shelf life. The Fischer esterification method is
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Special Report Methyl ethyl ketone – A techno-commercial profile M ethyl ethyl ketone (MEK or 2-butanone) is an organic compound with the formula CH3C(O)CH2CH3. Its CAS number is 78-93-3. The colorless liquid ketone has a sharp‚ sweet odour of butterscotch and acetone. It is produced industrially on a large scale‚ and also occurs in trace amounts in nature. It is soluble in water and is commonly used as an industrial solvent. With natural and synthetic resins‚ MEK produces solutions with low viscosity
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Chapter 28: Nitration of Methyl Benzoate I. General Information: A.) Microscale Nitration of Methyl Benzoate B.) C.) May 17‚ 2008 D.) Reaction(s)‚ including molar masses and all relevant physical data E.) Mechanism for the nitration of chlorobenzene: II. Purpose: In this experiment we are to take a cold solution of an aromatic ester that is first dissolved in sulfuric acid and is then reacted with nitric acid. This is a highly exothermic reaction and is kept under control by means
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Title: Nitration of Methyl Benzoate Objective: To prepare methyl-3-nitrobenzene from nitration of methyl benzoate. Results and calculations: Density = 1.094 g/ml = Mass of methyl benzoate = 1.094 g/ml x 2.8 ml = 3.0632 g no. of mol of methyl benzoate = = 0.022499 mol 1 mol of methyl benzoate produced 1 mol of methyl m-nitrobenzene. Therefore‚ 0.022499 mol of methyl benzoate produced 0.022499 mol of methl
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Abstract: In this experiment‚ the methyl nitrobenzoate was prepared from methyl benzoate‚ concentrated HNO3‚ and concentrated H2SO4 via an electrophilic aromatic substitution reaction. The HNO3 and H2SO4 were combined to form a nitrating solution‚ which was mixed with a mixture of methyl benzoate and H2SO4. Percent yield for the final product was calculated followed by recrystallization and melting point was measured. Introduction: Nitration of Methyl Benzoate is one of the examples of
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