October 9‚ 2013 Partner(s): Acetylsalicylic Acid Synthesis Theory. This experiment was carried out to see how the hydroxyl group on the benzene ring in salicylic acid reacts with acetic anhydride to form an ester‚ and to make aspirin. Synthesis of Acetylsalicylic Acid occurs by protonation of carbonyl (C=O) group‚ and a nucleophilic attack of OH on the acetic anhydride. The ferric chloride test and melting point were used to test the purity of the results. A hypothesized recovery rater of above
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Aspirin analysis Introduction Aspirin‚ which is also known as acetylsalicylic acid. C9H8O4 is the chemical format for Asprin. The chemical structure of aspirin: Aspirin is anti-inflammatory. Aspirin is prepared by chemical synthesis from salicylic acid‚ by acetylation with acetic anhydride. The fact that it is an acid allows us to quantify the amount of aspirin in a solution. We would do this by by using an acid-base titration. Sodium hydroxide (NaOH) will be used In this experiment as the
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Reference Manual: Experiment 3. Retrieved from: http://academic.reed.edu/chemistry/alan/201_202/lab_manual/expt_salicylic_acid/background.html 3.) Lab 5: Synthesis of Salicylic Acid. Retrieved from: http://academic.evergreen.edu/curricular/whatscookin/Lab%20five%20%20methyl%20saliclate.htm 4.) Handout: Synthesis of Salicylic Acid. Retrieved from: g.web.umkc.edu/gounevt/Orgo320L/Handouts/SalicylicacidW04.doc‚ (google search document download) 5.) Laboratory Reference Manual: Experiment 3‚ Notes
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Experiment 4: Heating Under Reflux- Synthesis of Salicylic Acid from Wintergreen Oil Precious Ahmed ID# 6463614 Section 07‚ Friday afternoon Lab experiment performed on: Friday‚ January 19‚ 2013 Lab report submitted on: Friday‚ January 24‚ 2013 Introduction Before the synthetic aspirin of today‚ salicylic acid‚ which is the important ingredient found in aspirin‚ was extracted naturally from methyl salicylate found in Wintergreen oil‚ which could be found in certain plants. The purpose
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control wilt disease complex in abaca caused by Fusarium oxysporum f. sp. cubense (FOC) and Ralstonia solanacearum. Suspected biological elicitors (Fomes and Xanthomonas oryzae pv. oryzae or Xoo) and known chemical elicitors (Asprin or Acetyl Salicylic acid and Boost) were sprayed to the abaca tissue cultured seedlings at 15 days interval together with water and Nordox (fungicide with bactericidal activity) as checks. The sprayed seedlings were challenged by simultaneous inoculation with FOC and
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Acetylsalicylic Acid Experiment 01/25/2013 CHM Lab- 2211 Sec 0016 Instructor: Jennifer Reed Introduction: Commonly used as Aspirin‚ acetylsalicylic acid is an analgesic (pain reliever)‚ which is one of the products of the esterification reaction between salicylic acid and acetic anhydride. This esterification occurs since the hydroxyl group from the salicylic acid reacts with acetic anhydride to form an ester. In this experiment‚ we will be able to recreate this acid catalyzed reaction
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leaves were also found to contain salicylic acid. Two Italians‚ Brugnatelli and Fontana‚ had in fact already obtained salicin in 1826‚ but in a highly impure form. Johann Buchner‚ professor of pharmacy at the University of Munich‚ isolated a tiny amount of bitter tasting yellow‚ needle-like crystals‚ which he called salicin (1828). Henri Leroux had improved the salicin extraction procedure to obtain about 30g from 1.5kg of bark (1829). An additional source of salicylic acid was found in 2835 by the German
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efficiency and purity. The purpose of our experiment was to synthesize acetyl salicylic acid (aspirin) and then determine the relative purity of the synthesized sample by observing the melting point temperature range. The procedure performed in our experiment involved chemically reacting salicylic acid and acetic anhydride in order to form acetyl salicylic acid. The limiting reactant in this chemical reaction was salicylic acid‚ with acetic anhydride present in excess in order to react with any water
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absorptivity of salicylic acid To determine the concentration of dissolved aspirin in heated water at various times To determine the effective rate constant of the decomposition of aspirin in heated water at 85°C. Results and Discussion The molar absorptivity of salicylic acid‚ ε‚ can be calculated from the equation‚ A = εcl. A more accurate value can be obtained by finding the gradient of a graph of absorbance of the iron complex‚ A‚ against varying values of c‚ concentration of salicylic acid. The value
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Learning Goals 1. To synthesize aspirin from salicylic acid and acetic anhydride. 2. To purify the crude product by Recrystallization. Introduction Most drugs are chemical compounds which are described as "organic compounds" because they are comprised primarily of the elements carbon‚ hydrogen and oxygen. The present experiment will be the synthesis of a familiar organic compound called aspirin. The common chemical name is acetylsalicylic acid. Aspirin‚ the most widely used drug in
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