Genetics of Sickle Cell Anemia Objectives • To observe how a disease can act as a selective force • To describe changes in allele frequencies in a population as a result of a selective force Hypothesis The starting ratio of HbA to HbS is 3:1; in a typical population‚ the Homozygous Dominant Gene would become the standard‚ but because carrying the Heterozygous version of the allele has an advantage to fighting Malaria it will become the dominant Allele for the population. The HbA/HbS gene will
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Agee Ms. Songer AP Biology February 16 2015 Sickle Cell Anemia: Case Study Summary Sickle Cell Anemia is a painful diseases that is caused by a mutation in the protein called hemoglobin which helps carry oxygen in red blood cells. Because of the mutation‚ the hemoglobin is shaped oddly which results in pain because it is hard for the blood to travel throughout the body and anemia because of the lack of oxygen in the blood. A person can only have this disease if both parents are carriers and they receive
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Sickle Cell Anemia Sickle Cell Anemia occurs in about 1 out of 500 African American births‚ and 1 out of 36‚000 Hispanic births. It is a lifelong disease‚ and sometime can be deadly. According to Dr. Whittaker‚ in our region there are abnormally higher cases of Sickle Cell Anemia‚ so I found it important to learn more about the disease‚ what cause it‚ what are the symptoms as well as the options of treatments for this disease. According to www.invista.com‚ it is believed that sickle cell disease
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Sickle Cell Anemia Sickle Cell Anemia is a blood disorder that shortens the life span of red blood cells‚ and eventually the organisms they are located in. Sickle Cell Anemia is an inherited blood disorder that changes that structure of red blood cells. In a healthy organism‚ red blood cells are disk shaped and move easily through the blood vessels. In an organism that has sickle cell anemia the red blood cells’ structures are corrupted; instead of the disk-like shape‚ the red blood cells have
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Sickle cell anemia was first discovered in the year of 1910. A young man by the name Walter Clement Noel from the island of Grenada‚ studied in Chicago. He went to Dr. James B. Herrick‚ whom was a cardiologist‚ with symptoms of anemia‚ who assigned Dr. Ernest Irons to the case. There Dr. Irons noticed that Noel’s red blood cells were the shape of a sickle. Although sickle cell anemia has occurred in Africa for thousands of years‚ Dr. Herrick was the first to provide a formal description of sickle
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Sickle Cell anemia is a group of inherited red blood cell disorders‚ or a collection of recessive genetic disorders characterized by a hemoglobin variant called Hb S. Normal red blood cells are round like doughnuts‚ and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard‚ sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube‚ they clog the flow and break apart. This can cause pain‚
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Sickle cell anemia (SCA) is a genetic disorder that is hereditary. It affects the blood‚ and is caused when the hemoglobin in blood cells are deprived in oxygen from the proteins. These cause normal round blood cells‚ to have are rigid sickle shape. People affected by SCA have a higher risk of death‚ stroke‚ severe attacks‚ and severe rushes of pain. James Herrick discovered an anemia‚ and found bizarre sickle-shaped cells in 1910. A treatment for the disease was discovered in the 1920s by E. Vernon
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Introduction - sickle cell anemia The first suggestion that genes might provide the information for all proteins came from Linus Pauling’s lab at Caltech. He and his student Harvey Itano studied hemoglobin‚ the protein in red blood cells that transports oxygen from the lung to metabolically active tissues‚ like muscle‚ where it is needed. In particular‚ they focused on the hemoglobin of people with sickle-cell disease‚ also known as sickle-cell anemia‚ a genetic disorder common in Africans‚ and
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Adams 1 Dwayne Adams Instructor: Croshaw Medical Terminology 1 18‚ April 2013 Sickle Cell Anemia Sickle-cell Anemia is a genetic blood disorder caused by the presence of an abnormal form of hemoglobin molecules in which the red blood cells loose their disc-shape and become crescent shaped. The shape also known as “hemoglobin S”. unlike normal red cells which are usually smooth and malleable‚ tend to collect after releasing oxygen‚ and cannot squeeze through small blood vessels. The
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Case Study 97 1. Sickle cell disease is a group of disorders that affects hemoglobin‚ the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S‚ which can distort red blood cells into a sickle‚ or crescent‚ shape. SCD affects millions of people worldwide‚ particularly those with African‚ Spanish‚ Mediterranean‚ and Indian ancestry. Some 120‚000 infants are born with SCD every year worldwide
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