Lab 7: SN1 and SN2 Reactions Discussion/Conclusion: In this experiment the purpose of the lab was to study the relationship of structure and reactivity in nucleophilic substitution reactions by using qualitative tests of reactivity. Before the experiment began‚ students were asked to predict whether the reagents would cause an SN1 mechanism‚ SN2 mechanism‚ or both. When predicting the outcome of SN1 and SN2 reactions‚ the nature of the carbon skeleton‚ nature of the solvent‚ and the nature of
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Experiment 15 & 16: Preparation of 1-bromobutane‚ an SN2 reaction Preparation of 2-chloro-2-methylbutane‚ an SN1 reaction Introduction The purpose of this experiment is to synthesize 1-bromobutane from 1-butanol and sodium bromide. In order for this reaction to reach completion there are four major operations that need to be performed. The four major operations include refluxing‚ simple distillation‚ separation‚ and drying. To begin‚ in order for the compounds to react they will be dissolved
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SN1 Reactions For SN1 reactions it’s important to have a good leaving group because this reaction occurs in two steps. Because alcohol is such a poor leaving group it needs to be helped by silver nitrate to help promote the ionization of the alkyl halide. This helps form the products of the SN1 reaction. 2-chlorobutane This reaction didn’t occur because the carbocation isn’t stable enough for an SN1 reaction. 2-bromobutane This reaction occurred in 32 seconds. This reaction occurred quickly
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Summary of Chapter 11 Material SN2 Reaction Substrate: NO SN2 ON A TERTIARY HALOALKANE!! order of reactivity is as follows: Methyl > 1 > 2 Sterically less hindered substrates have faster rates in SN2 Nucleophile: If the reacting atom is the same in a series‚ nucleophilicity parallels basicity (i.e. -OH > -OCH3 > -OCH2CH3 > H2O) For the halogens in GAS PHASE: F- > Cl- > Br- > IFor the halogens in SOLUTION: I- > Br- > Cl- > F- (due to solvation of nucleophile‚ rendering it inactive) Negatively
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Reminder: These notes are meant to supplement‚ not replace the laboratory manual. SN1 Reaction Notes Background and Application Substitution Nucleophilic First Order (SN1) reactions are one of the most common type of organic reactions. SN1 reactions can be used to make a wide variety of new compounds. In this experiment‚ t-amyl alcohol will be converted by a SN1 mechanism to 2-chloro-2-methylbutane. Safety Precautions Concentrated Hydrochloric Acid is 12M. It will cause visible destruction
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TA: Alekhya 6/15/15 The SN2 Reaction: Factors Affecting SN2 Reaction. Introduction In the substitution reactions‚ the leaving group from the substrate is replaced with the nucleophile. Because of the nucleophile it is called nucleophilic substitution. The lone pair of electrons‚ present on the nucleophile is used to create a new bond with the carbon atom‚ from which the leaving group was separated. There are two different mechanisms of nucleophilic substitution: SN1 and SN2. The difference between
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Kinetics of an SN1 reaction: the effect of solvent on rate Object The purpose of this experiment is to determine the rate of hydrolysis in acetone/water (50/50 v/v and 60/40 v/v). Background and Theory An SN1 reaction of tert-butyl chloride takes place in two steps. First‚ the Alkyl Halide will leave the molecule. In this step the bond is breaking‚ which takes a longer amount of time‚ so it will determine the rate of the reaction. As a result‚ it forms a tertiary carbocation‚ since this
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Studying SN1 and SN2 Reactions: Nucleophilic Substitution at Saturated Carbon Date of Experiment: February 6‚ 2008 Objective: The objective of this laboratory experiment is to study both SN1 and SN2 reactions. The first part of the lab focuses on synthesizing 1-bromobutane from 1-butanol by using an SN2 mechanism. The obtained product will then be analyzed using infrared spectroscopy and refractive index. The second part of the lab concentrates on how different factors influence the rate of SN1 reactions
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Title: Studying SN1 and SN2 Reactions: Nucleophilic Substitutions at the saturated carbon Lab Partner: Jeszie Geronimo Objective and purpose: the purpose of this experiment is to convert a primary alcohol to an alkyl bromide using a Sn2 Reaction. Investigate some factors that influence the rate of Sn1 reactions. The second part of this lab will focus more on how unlike factors influence the rate of reactions in anSN1 reactions. The factors that we will be inspecting are the leaving groups‚ Cl-
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The SN2 reaction requires three qualities: a strong nucleophile‚ a good‚ unhindered leaving group‚ and a polar‚ aprotic solvent. For our reaction‚ we have all three bases covered. The nucleophile is an alkoxide‚ a deprotonated alcohol. Technically‚ because our alcohol is a phenol‚ the conjugate base is called a phenoxide. Phenol itself has a pKa of about 10‚ but our alcohol has more resonance opportunities‚ so the pKa is down around 8. This is sufficiently acidic for use of weak base like K2CO3 for
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