Dale TA: Alekhya 6/15/15 The SN2 Reaction: Factors Affecting SN2 Reaction. Introduction In the substitution reactions‚ the leaving group from the substrate is replaced with the nucleophile. Because of the nucleophile it is called nucleophilic substitution. The lone pair of electrons‚ present on the nucleophile is used to create a new bond with the carbon atom‚ from which the leaving group was separated. There are two different mechanisms of nucleophilic substitution: SN1 and SN2. The difference between
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Preparation and SN1 Reactivity of 2-Bromobutane Paul DeJong Department of Chemistry‚ Illinois State University‚ Normal‚ IL 61790-4160 Submitted: April 4‚ 2013 Introduction The purpose of part 1 of the lab is to prepare 2-Bromobutane using SN1 reactions. The purpose of part 2 of the lab is to determine the relative reactivity of alkyl halides under SN1 conditions. Results and Discussion The Overall Reaction The Proposed Mechanism Experimental Procedure To prepare
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substitution methods. These methods include SN1 and SN2 mechanism‚ both of which can occur for this type of reaction. For both reactions‚ the first step of protonation will be to add hydrogen to the –OH group and then the rest of the reaction will proceed according to the type of mechanism. SN1 reactions form a cation intermediate once the H2O group leaves‚ then allowing a halide (such as Br) to attack the positively charged reagent1. On the other hand‚ SN2 reactions are one-step mechanism in which no
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(Wade‚ 7 ed.) • 6.7 (p. 228) Reactions of alkyl halides • 6.8 – 6.12 (p. 229 – 242) The SN2 reaction: generality‚ factors affecting SN2 reactions‚ substrate reactivity‚ mechanism • 6.13 – 6.14 (p. 243 – 249) The SN1 reaction: mechanism‚ stereochemistry General Concepts The most common of the variety of methods available for preparing alkyl halides is the replacement of the hydroxyl group of an alcohol. This type of reaction is representative of an important class of reactions in organic chemistry called
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CHEM 206- ORGANIC CHEMISTRY EXP 10-UNIMOLECULAR ELIMINATION REACTIONS Cansın Etli Lab Instructor: Emel Yılgör Experiment date:06.12.2010 Report Date: 20.12.2010 ABSTRACT In this experiment‚ the purpose was to investigate E1 elimination mechanism with the reaction of cyclohexanol to cyclohexene. The reaction was acid catalyzed dehydration of alcohol and with catalyst sulfuric acid cyclohexene was obtained from cyclohexanol. And the product
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Title: Relativities of Alkyl Halides in Nucleophilic Substitution Reactions Introduction: The purpose of this lab was to perform a comparison of relative reactivities of various alkyl halides with two different reagents‚ sodium iodine in acetone and silver nitrate in ethanol. (Below are the reaction equations). We used different substrates‚ which were primary‚ secondary‚ and tertiary. These substrates included 2-bromobutane‚ 2-bromo-2-methylpropane‚ 1-bromobutane ∞-Bromotoluene‚ bromobenzene
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In this experiment‚ the objective is to successfully perform an SN1 reaction to determine the reactivity of tert-butyl chloride‚ through the usage of sodium iodide/silver nitrate reagents and to synthesize tert-butyl chloride. The tert-butyl chloride was synthesized through the use of separation (aqueous and organic layers) and distillation. Tert-butyl chloride is the alkyl halide which is being synthesized throughout the course of the experiment. Alkyl halides are derived from alkanes. Once an alkane
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Title: Studying SN1 and SN2 Reactions: Nucleophilic Substitutions at the saturated carbon Lab Partner: Jeszie Geronimo Objective and purpose: the purpose of this experiment is to convert a primary alcohol to an alkyl bromide using a Sn2 Reaction. Investigate some factors that influence the rate of Sn1 reactions. The second part of this lab will focus more on how unlike factors influence the rate of reactions in anSN1 reactions. The factors that we will be inspecting are the leaving groups‚ Cl-
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The Wittig reaction is a unique reaction that can be carried out in various ways as our prompt exemplifies. We will be primary focusing on the second of the three schemes. In The usual formation of an ylide occurs via Sn2 attack of a PR3 group on an alkyl halide‚ which is then followed by a strong base deprotonating of one of the hydrogens on the methyl which the PR3 attacked. Before we dive into the details of the reaction occurring in scheme 2 it will be important to understand the mechanism which
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The SN2 reaction requires three qualities: a strong nucleophile‚ a good‚ unhindered leaving group‚ and a polar‚ aprotic solvent. For our reaction‚ we have all three bases covered. The nucleophile is an alkoxide‚ a deprotonated alcohol. Technically‚ because our alcohol is a phenol‚ the conjugate base is called a phenoxide. Phenol itself has a pKa of about 10‚ but our alcohol has more resonance opportunities‚ so the pKa is down around 8. This is sufficiently acidic for use of weak base like K2CO3 for
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