Determination of Gatifloxacin and Ornidazole in Tablet Dosage Forms by High-Performance Thin-Layer Chromatography 43 A simple and sensitive high-performance thin-layer chromatography method has been developed for the quantitative estimation of gatifloxacin and ornidazole in its combined dosage forms. Gatifloxacin and ornidazole were chromatographed on silica Gel 60 F254 TLC plate using n-butanol: methanol: ammonia (6 M) (8:1:1.5 v/v) as the mobile phase and scanned at 302 nm using a Camag TLC Scanner
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Atrazine (1-chloro-3-ethylamino-5-isopropylamino-2‚ 4‚ 6-triazine‚ CAS: 1912-24-9) was purchased from Dr. Ehrenstorfer GmbH (97.7%‚ Germany). Ethyl acetate (99.8%‚ ANPEL Scientific Instrument (Shanghai) Co.‚ Ltd.) was used as solvent for standard solutions. Acetonitrile used as HPLC eluent was purchased from ANPEL Scientific Instrument (Shanghai) Co.‚ Ltd.‚ KH2PO4·12H2O‚ K2HPO4·2H2O‚ dichloromethane and other chemical reagents used in cultivated media were purchased from Sinopharm Chemical Reagent
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Results and discussion The aqueous solubility of midazolam is a function of both the imidazobenzodiazepine ring opening‚ which is a fully reversible process‚ and the ionization of the drug molecule play an important role in the supramolecular complexation with water-soluble cyclodextrins (Loftsson et al.‚ 2001). Therefore‚ the total charges were assessed from the acid dissociation constant determined for different forms of midazolam as depicted in Figure 1. First‚ predicted negative decimal logarithm
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J uly 5 ‚ 1960 & BUTYL STERS PEPTIDEYNTHESIS E IN S g roup occupies t he same position of the peptide chain in both mercaptalbumin and non-mercaptalbumin. 3359 Acknowledgments.-The authors are grateful to Mrs. J . O’Brien and Mr. 0. Griffith for their technical assistance. [ CONTRIBUTION T HE O RCAXIC FROM CHEMICAL RESEARCH SECTION‚ LEDERLE LABORATORIES v r s r o x ‚ MERICAN VASAMID U~ A C R Co.‚ PBARLIVER‚X. Y . ] &Butyl Esters of Amino Acids and Peptides and their
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RESULTS AND DISCUSSION: Ultraviolet spectroscopy of Verapamil hydrochloride at λmax of 278 nm in pH 1.2 buffer was found to be linear in range of 20 – 80 µg/ ml. The method was validated and found to be precise‚ specific and accurate. The tablets of Verapamil hydrochloride were prepared by press coating technique showing sustained release for 24 h for once daily dosing with a lag phase of 4 - 6 h. The optimum ratios and type of polymers and other excipients were chosen to produce gastroretentive
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Steam Distillation – Clove Oil Abstract: In this experiment‚ a situ method steam distillation was performed and essential oils were isolated from cloves. Once the oils were obtained‚ extraction techniques were used to extract a crude‚ eugenol‚ and acetyleugenol product sample. These samples were submitted for GC analysis and the normalization area percents were calculated to confirm their purity; for the crude sample it was 93.95% eugenol and 6.05% acetyleugenol‚ for the eugenol sample it
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Exercise No. 2 TERNARY SYSTEMS Liezel Angelique L. Sabaupan‚ Bethel Faith Rezaga‚ and Bea Eder Date of Performance: July 1‚ 2013; Date Submitted: July 11‚ 2013; Lab Section: 1L; Instructor: Prof. Annabelle T. Abrera Abstract Ternary systems are represented in a Gibbs-Roozeboom diagram. Since a three-component system offers four degrees of freedom‚ temperature and pressure are held constant. A mixture of acetic acid‚ water and chloroform was studied in this experiment. A binodal curve was constructed
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Asymmetric Epoxidation of Dihydronaphthalene with a Synthesized Jacobsen’s Catalyst Justin Lindsey 12/08/96 Chem 250 GG Professor Tim Hoyt TA: Andrea Egans Abstract. 1‚2 diaminocyclohexane was reacted with L-(+)-tartaric acid to yield (R‚R)-1‚2-diaminocyclohexane mono-(+)-tartrate salt. The tartrate salt was then reacted with potassium carbonate and 3‚5-di-tert-butylsalicylaldehyde to yield (R‚R)-N‚N’-Bis(3‚5-di-tert-butylsalicylidene)-1‚2-cyclohexanediamine‚ which was then reacted with Mn(OAc)2*4H2O
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Preparation of Synthetic Banana Oil Introduction: In this lab the synthesis‚ purification‚ and characterization of isoamyl acetate‚ or banana oil‚ was determined. The synthesis was completed by a reversible esterification reaction which required the heating of glacial acetic acid and isoamyl alcohol‚ combined with a sulfuric acid catalyst in hexane. In order to increase the efficiency of the reaction‚ LeChatelier’s Principle is utilized by removing water from the products. As a result‚ the reaction
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Chem 2203 Sec 026 27/September/2013 Experiment 3B: Fractional Semi-microscale Distillation Separation of Hexane and Toluene. Objective: The main goal of this lab is to learn how separation of binary liquid mixtures is performed. Especially when the two liquids have boiling points varying by about 30° C. Hexane can be separated from toluene in this experiment because of the difference in their boiling points. Since toluene has a higher boiling point‚ it will left at the bottom while the hexane
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