Synthesis of Aspirin Learning Goals 1. To synthesize aspirin from salicylic acid and acetic anhydride. 2. To purify the crude product by Recrystallization. Introduction Most drugs are chemical compounds which are described as "organic compounds" because they are comprised primarily of the elements carbon‚ hydrogen and oxygen. The present experiment will be the synthesis of a familiar organic compound called aspirin. The common chemical name is acetylsalicylic acid. Aspirin‚ the most
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Preparation and melting point of Aspirin Aspirin is a painkilling drug and is produced worldwide to reduce and stop pain. Aspirin is made up of ehtanoylation of 2-hydroxbenzenecarboxylic acid in a presence of phosphoric acid. AIM: The aim of the experiment is to prepare and produce aspirin as pure as possible. I will do this threw preparing the aspirin and purifying the product threw recrystallization. I will then obtain a melting point of my product to get an estimate of its purity. By the end
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Aspirin or acetylsalicylate acid is a compound that is widely used in medicine. The use of aspirin in medicine began long before the active reagent was removed from its natural source. The first documented use of aspirin was found in the writings of Hippocrates‚ the so called father of medicine. Hippocrates prescribed that willow bark could be used to remedy a wide range of conditions such as pain‚ fever and inflammation. Scientists began to seek to extract the active compound from willow tree bark
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Jennie K. Daniels Organic Chemistry 2121 11 February 2014 Synthesis of Aspirin Salicylic acid derivatives‚ or salicin‚ are found in the bark of the willow tree. In the 5th century B.C.‚ Hippocrates ground the bark into a powder‚ and later‚ the Natives Americans chewed on the bark to alleviate fever and pain1. In the 19th century‚ a German chemist by the name of Felix Hoffman wanted to find a medication that would ease
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EXERCISE 11 SYNTHESIS OF ASPIRIN MARAVILLA‚ Ana Mikaela B Group 4 CHEM 40.1 1L Date performed: September 30‚ 2013 Date submitted: October 7‚ 2013 VI. RESULTS AND DISCUSSION Aspirin is prepared by the esterification of salicylic acid with acetic anhydride under acidic conditions. The phenol group in salicylic acid is replaced by a carboxyl group through electrophilic substitution. The mechanism for the reaction can be summarized
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Experiment 2 and 3: Synthesis of Aspirin and Determination of Melting Point A. Abstract Aspirin is the common name for the compound acetylsalicylic acid‚ widely used as a fever reducer and as a pain killer. The first part of the experiment aims to synthesize aspirin from the reaction of salicylic acid with acetic anhydride with the aid of phosphoric acid as a catalyst. The second part of the experiment aims to assess the purity of aspirin through the determination of its melting point and
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Synthesis of Aspirin and Oil of Wintergreen INTRODUCTION: Synthesis and use of organic compounds is an extremely important area of modern chemistry. Approximately half of all chemists work with organic chemicals. In everyday life‚ many if not most of the chemicals you come in contact with are organic chemicals. Examples include drugs‚ synthetic fabrics‚ paints‚ plastics‚ etc. Synthesis of Aspirin and Methyl Salicylate. The two compounds we will be preparing‚ aspirin (acetylsalicylic acid) and oil
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Preparation of an Ester Acetylsalicylic Acid (Aspirin) OBJECTIVE: To become familiar with the techniques and principle of esterification. DISCUSSION: Aspirin is a drug widely used as an antipyretic agent (to reduce fever)‚ as an analgesic agent (to reduce pain)‚ and/or as an anti-inflammatory agent (to reduce redness‚ heat or swelling in tissues). Chemically‚ aspirin is an ester. Esters are the products of reaction of acids with alcohols‚ as shown in the following equation using
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Synthesis of Aspirin Name: Xuanyi Li Teaching assistant: Deirdre Zwilling November 15‚ 2009 Purpose: To synthesize aspirin‚ a common analgesic drug‚ via nucleophilic acid-catalyzed substitution reaction of salicyclic acid with acetic anhydride. The whole reaction is catalyzed by phosphoric acid. (The experiment involved three parts: The synthesis of aspirin‚ the isolation and purification of aspirin‚ and the estimation of the purity of the final product.) [pic] Procedure[1]: A mixture
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Greaves Chem3301-112 June 19‚ 2013 Synthesis of Aspirin from Methyl Salicylate Introduction The synthesis of Aspirin (Acetyl Salicyclic Acid) began with methyl salicylate and sodium hydroxide as the reagent. The polar oxygen accepts the electrons from now positively charged hydrogen. The positively charged sodium disassociates leaving the hydroxide ion with a negative Scheme 1 shows the mechanisms that were demonstrated during the synthesis of Aspirin. charge that attracts to the positively charged
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