In this experiment‚ the objective is to successfully perform an SN1 reaction to determine the reactivity of tert-butyl chloride‚ through the usage of sodium iodide/silver nitrate reagents and to synthesize tert-butyl chloride. The tert-butyl chloride was synthesized through the use of separation (aqueous and organic layers) and distillation. Tert-butyl chloride is the alkyl halide which is being synthesized throughout the course of the experiment. Alkyl halides are derived from alkanes. Once an alkane
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Hydrolysis of tert-butyl Chloride in different solvents Practical conducted on 5 March‚ 2013 Reported by Pham Vu Hung on 10 March‚ 2013 Introduction: This practical is meant to measure the rate of reaction of the hydrolysis of tertiary-butyl chloride –a colorless‚ liquid organic compound at room temperature that is sparingly soluble in water - in water/acetone and water/isopropanol mixtures. Since there are many influencing factors for the rate of reaction‚ all are kept constant but the
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of t-Butyl-Chloride March 8 & 15‚ 2012 Theory: Alkyl halides can be synthesized when alcohols react with hydrogen halides. An alkyl halide is a halogen-substituted alkane‚ and a hydrogen halide is a compound consisting of a hydrogen bonded to a halogen (H-X). Alkyl halides are classified as primary‚ secondary‚ or tertiary depending on the number of alkyl substituents directly attached to the carbon bearing the halogen atom. The purpose of this laboratory experiment was to prepare t-butyl-chloride
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SN1 Reactions For SN1 reactions it’s important to have a good leaving group because this reaction occurs in two steps. Because alcohol is such a poor leaving group it needs to be helped by silver nitrate to help promote the ionization of the alkyl halide. This helps form the products of the SN1 reaction. 2-chlorobutane This reaction didn’t occur because the carbocation isn’t stable enough for an SN1 reaction. 2-bromobutane This reaction occurred in 32 seconds. This reaction occurred quickly
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Reminder: These notes are meant to supplement‚ not replace the laboratory manual. SN1 Reaction Notes Background and Application Substitution Nucleophilic First Order (SN1) reactions are one of the most common type of organic reactions. SN1 reactions can be used to make a wide variety of new compounds. In this experiment‚ t-amyl alcohol will be converted by a SN1 mechanism to 2-chloro-2-methylbutane. Safety Precautions Concentrated Hydrochloric Acid is 12M. It will cause visible destruction
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Preparation and SN1 Reactivity of 2-Bromobutane Whitney Bellido Department of Chemistry‚ Illinois State University‚ Normal‚ IL 61790-4160 Submitted: April 4th‚ 2013 Introduction The overall goal of this experiment is to understand and be familiar of SN1 reactivity. We also learned how to prepare 2-Bromobutane by learning how to distill and extract this product from its organic layer. Finally‚ another goal was to specifically understand the relative reactivity of alkyl halides under SN1 conditions
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The tert-butyl group has been broadly used to protect functional groups in natural product synthesis such as amino acid‚ peptide and protein chemistry [1]. The tert-butoxycarbonyl (BOC) group is known as protecting group for amides in organic synthesis. The introduction of BOC group improves the solubility of organic precursors and their processability in organic synthesizes [2]. The methyl substituted pyridine derivatives were widely reported for their various biological activities such as anxiolytic
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Preparation and SN1 Reactivity of 2-Bromobutane Paul DeJong Department of Chemistry‚ Illinois State University‚ Normal‚ IL 61790-4160 Submitted: April 4‚ 2013 Introduction The purpose of part 1 of the lab is to prepare 2-Bromobutane using SN1 reactions. The purpose of part 2 of the lab is to determine the relative reactivity of alkyl halides under SN1 conditions. Results and Discussion The Overall Reaction The Proposed Mechanism Experimental Procedure To prepare
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Kinetics of an SN1 reaction: the effect of solvent on rate Object The purpose of this experiment is to determine the rate of hydrolysis in acetone/water (50/50 v/v and 60/40 v/v). Background and Theory An SN1 reaction of tert-butyl chloride takes place in two steps. First‚ the Alkyl Halide will leave the molecule. In this step the bond is breaking‚ which takes a longer amount of time‚ so it will determine the rate of the reaction. As a result‚ it forms a tertiary carbocation‚ since this
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Lab 7: SN1 and SN2 Reactions Discussion/Conclusion: In this experiment the purpose of the lab was to study the relationship of structure and reactivity in nucleophilic substitution reactions by using qualitative tests of reactivity. Before the experiment began‚ students were asked to predict whether the reagents would cause an SN1 mechanism‚ SN2 mechanism‚ or both. When predicting the outcome of SN1 and SN2 reactions‚ the nature of the carbon skeleton‚ nature of the solvent‚ and the nature of
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