Investigating Aspirin Aims Synthesize my own aspirin Analyse the purity of my aspirin samples (aspirin and recrystallized aspirin) compared to commercial aspirin by use of analysing melting points‚ TLC plates and colorimetry tests Investigate how pH effects the rate of hydrolysis of aspirin Background theory Making my own sample of Salicylic acid (to then be converted into Aspirin) Salicylic acid (2-Hydroxybenzoic acid) can be made by hydrolysing methyl 2-hydroxybenzoate. Oil
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What is Aspirin? Aspirin is on of the first drugs to ever be commonly used and is still one of the most widely used in the world. How widely used you ask? Approximately 35000 metric tonnes are produced and consumed every year. Chemically aspirin is known as acetylsalicylic acid with the chemical formula of C9H8O4. Aspirin is an analgesic‚ anti-inflammatory‚ antipyretic‚ and is an inhibitor of platelet aggregation. The history of Aspirin Aspirin has been a major part of just about everyone’s
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“Aspirin has been used for many years; it is well-understood‚ effective‚ inexpensive and widely available.” - Dr. Jeffrey Berger In the last 30 years medicines prescribed by doctors have changed beyond all recognition. Our better knowledge of the nature of diseases and their management has led to the replacement of many old remedies by new ones specifically designed for each illness. Everyone has known for years that
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Commercial Aspirin Tablet Analysis Tuesday Evening Intro: The purpose of this lab was to analyze commercial aspirin tablets. To do so‚ the percent acetylsalicyclic acid (active ingredient) in tablets using acid-base titration was determined‚ the percent acetylsalicyclic acid in tablets by formation of a colored iron(III)-salicylate complex was determined using spectrometry‚ and then the percents from each process was compared. Acetylsalicylic acid is produced when salicylic acid and acetic
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FOUNDATION IN SCIENCE INTRODUCTION TO PRACTICAL ORGANIC CHEMISTRY – MAKING AND PURIFYING ORGANIC COMPOUNDS Stage 1 – Deciding how much reagent to use Most organic reactions do not go to completion; most reach an equilibrium position with significant quantities of reactants still remaining. In addition‚ separating the desired product from the rest of the reaction mixture‚ and then purifying it‚ will result in the loss of more of the product. The amount of product obtained expressed as a percentage
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October 17 & October 24‚ 2012 How is Aspirin Made? This lab is about synthesizing aspirin using a hotplate to heat the reaction. It involved vacuum filtration‚ recrystallization‚ and comparing the properties of aspirin with salicylic aspirin. The first thing we did in this lab was make a hot-water bath by putting a beaker with water on a hot plate. After measuring out 2.1 grams of salicylic acid and 3 ml of acetic anhydride‚ we mixed the two together‚ along with 3 drops of sulfuric acid. We
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CHEM%2315%Fall%2014% Creating useful and beautiful molecules using synthetic organic chemistry – Synthesis of Aspirin and Indigo INTRODUCTION Aspirin Salicylic acid occurs naturally in the bark of willow trees. Prior to the 1800’s‚ willow bark was often brewed into a tea‚ or chewed to relieve pain. While the salicylic acid is effective at reducing pain it was found to irritate the lining of the stomach. It was mostly by chance that on August 10‚ 1897 Felix Hoffmann‚ a German chemist who obtained
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Experiment 7a Name: Date: Title: Purity of Aspirin by Spectrophotometry Aim: i. To measure the absorbance of different volumes of sodium salicylate solutions and aspirin with iron chloride ii. To find the concentration of each standard solutions iii. To determine percentage purity of aspirin. Abstract: The mass of acetylsalicylic acid was determined using a analytical balance. Sodium hydroxide (NaOH) was added to the acetylsalicylic acid and heated in order to hydrolyze acetylsalicylic
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Name Period Date The Synthesis of Aspirin Background Pharmaceutical research labs perform chemical reactions between organic molecules that contain mostly carbon. Since the atoms in organic molecules tend to be nonmetals‚ then the bonds that hold them together are covalent bonds. Only a few elements on the periodic table are nonmetals: C‚ N‚ O‚ S‚ Cl‚ and F. This small number of elements can be bonded together in different quantities‚ bonding types (single‚ double‚ triple bonds)‚ and structural
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preparation of aspirin and oil of wintergreen | Introduction Organic compounds are those which contain carbon as well as a select other elements. An organic acid however‚ is an organic compound which contains acidic properties. An ester is an example of being a derivative of these organic acids. Esters can be prepared by the reaction of carboxylic acids and alcohols‚ with an inorganic acid used as a catalyst which is dubbed esterification. With o-hydrobenzoic acid‚ or salicylic
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