Synthesis of Acetanilide By: Rick Whitely April 9‚ 2013 Organic Chemistry Lab 1; Professor J. Hutchison Recrystallization is a common method of purifying organic substances through the differences in solubility at different temperature. In this experiment‚ acetanilide was produced by acetylation of aniline with acetic anhydride. The crude acetanilide was dissolved in a solvent in a heated water bath. The solution was cooled slowly in an ice bath as crystals form out. As the compound crystallizes
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Synthesis of p-Nitroacetanilide (electrophilic aromatic substitution) In this experiment‚ we convert acetanilide to p-nitroacetanilide. [pic] The mechanism for the nitration is that of electrophilic aromatic substitution. The nitronium ion is directed to the positions ortho and para to the acetamido (-NHCOCH3) group. This occurs because the resonance electron-releasing effect of that group increases the electron density at those positions‚ helping to stabilize the intermediates that
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BROMINATION OF ACETANILIDE OBJECTIVE Aim of the experiment was too brominate acetaldehyde to form p-bromoacetanilide. INTRODUCTION Acetanilide is a chemical compound with the chemical formula of C6H5NH(COCH3). It is a crystalline solid that is prepared by acetylation of analine and is widely used in the dye industry. This crystalline solid is an odourless solid chemical that has a flake or leaf like appearance. It is also known as N phenylacetamide‚ acetanil or acetanilide. Its former
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Synthesis of Acetanilide Reaction O NH2 + H3C C O O C CH3 O N C CH3 H + H3C O C OH Aniline Acetic anhydride Acetanilide Acetic acid Purpose: Acetanilide is a useful precursor to many pharmaceuticals such as acetaminophen and penicillin. Experimental Procedure. (Estimated time: 1.5 h.) Unless otherwise noted‚ all manipulations should be done in the chemical fume hood. Place 100 µL of aniline into a tared 10 X 75-mm test tube (standing in a small beaker or Erlenmeyer flask). Now add
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Learning Activity 1 Preparation of Acetanilide Abstract Recrystallization is a common method of purifying organic substances through the difference in solubility at different temperature. In this experiment‚ acetanilide was produced by acetylation of aniline with acetic anhydride. The crude acetanilide was dissolved in a solvent in a heating water bath. The solution was cooled slowly in an ice bath as crystals form out. As the compound crystallizes from the solution‚ molecules of other compounds
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Bromination of Acetanilide Objective: The objective of this experiment was to use melting point and NMR to determine which of two isomers‚ ortho or para‚ would most likely form after brominating Acetanilide through electrophilic aromatic substitution. Procedure/Observations: 1. Weigh out ~280 mg of acetanilide in a 10 mL r.b. flask with a stir bar. 2. Then‚ add 2.0 mL of glacial acetic acid using a calibrated Pasteur pipet. 3. Stir the mixture until all of the acetanilide has dissolved
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Bromination of Acetanilide Introduction: Bromination of acetanilide to 4-bromoaniline was studied in this experiment. One of the most important mechanism with the reaction of aromatic compounds is the electrophilic aromatic substitution reactions(wade‚2013). The electrophilic aromatic substitution enable scientists to make substituted aromatic compounds. However‚ substitution groups affect the electrophilic substitution mechanism. A nitrogen atom attached to hydrogen is learned to be a powerful
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CHEMISTRY 220 PRACTICAL REPORT PRACTICAL 1 Title: Nitration of Acetanilide Aim : To observe how an Aromatic electrophilic Substitution reaction takes place via the nitration of Acetanilide i.e. how hydrogen on a carbon chain is replaced with a nitro group. Reagents and Chemicals: • Acetanilide (5g) • Glacial acetic acid (5mL) • Concentrated sulphuric acid (10mL &1.5mL) • Concentrated Nitric acid (2.0mL) • Methanol (30-50mL) Modification to experimental
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146 Fall-11 Organic Chemistry Midterm Report 13 October 2011 Table of Contents Separation of Benzoic Acid and Acetanilide 3 Extraction and Purification of Caffeine from Tea 4 Extraction of Trimyristin from Nutmeg 5 Conversion of t-butanol to t-butyl chloride 6 Appendix 7 Calculations 8 Literature and Experimental Values of Benzoic Acid and Acetanilide 9 Experimental Caffeine IR 10 Literature Caffeine IR 11 Experimental Trimyristin IR 12 Literature
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Q: Which of the ff are branches of the aortic arch? A: Brachiocephalic‚ left common carotid‚ left subclavian Q: Which of the ff are branches of the subclavian arteries? A: thyrocervical‚ internal thoracic‚ and vertebral artery Q: Where is the carotid sinus located? A: Base of the internal carotid Q: Which of the ff are branches of the internal carotid? A: middle cerebral‚ anterior cerebral‚ ophthalmic artery Q: The gastroduodemal artery is a branch from which artery? A: Common hepatic artery
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