De-esterification for Synthesis of Benzoic Acid BATCH REACTOR Shane Bulk Chris Crosley David McGuire Max Skula Yunjing Song Shriram Sundarraj Nelson Zhou 155:416 Process Laboratory II Professor Jerry Sheinbeim January 28 – February 28‚ 2014 ABSTRACT The observed reaction that took place in this experiment was the de-esterification of ethyl benzoate to form benzoic acid. This experiment was used to determine the rate constant k of the synthesis of benzoic acid at different temperatures
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Synthesis of Salicylic Acid from Wintergreen Oil Objective – Preparation of salicylic acid (organic synthesis) from methyl salicylate utilizing previously used procedure from the nineteenth century. The final product will then be evaluated in comparison to salicylic acid made from benzene. Discussion – In this synthesis‚ methyl salicylate is the starting material or precursor and salicylic acid is the target product. It is the major constituent of wintergreen oil. The difference in structures
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Synthesis and Purification of Acetylsalicylic Acid (ASA or Aspirin) Background Salicylic acid is a phenol as well as a carboxylic acid. It can therefore undergo two different types of esterification reactions‚ creating an ester either with the hydroxyl or with the acid. In the presence of acetic anhydride‚ acetylsalicylic acid (aspirin or ASA) is formed. Correspondingly‚ an excess of methanol will form methyl salicylate‚ which is also an analgesic. In this experiment‚ we shall use
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Experiment #04: Synthesis of Salicylic Acid from Wintergreen Oil I. Introduction and Purpose Until 1874 commercial salicylic acid was synthesized entirely from natural wintergreen oil. In this experiment the salicylic acid is reproduced using methyl salicylate‚ the major constituent of wintergreen oil and later compared to salicylic acid made from benzene. The purpose of this lab is to determine the difference between salicylic acid made from methyl salicylate and salicylic acid made from benzene
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EXPERIMENT 4: Synthesis of Salicylic Acid from Wintergreen Oil Abstract: The purpose of this experiment is to take methyl salicylate (wintergreen oil) and by heating it under reflux with NaOH as a solvent‚ and then cooling the mixture with H2SO4 as another solvent‚ synthesize salicylic acid. The final step involves purify the product to produce as pure a sample of salicylic acid as possible. This process allowed for the successful production of 1.406g salicylic acid‚ an 82.70% yield. The NMR and
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objective of the experiment was to prepare Benzilic acid by multistep synthesis starting with benzaldehyde. In this setup however‚ product of the first step‚ Benzoin‚ is provided thereby omitting the first step involving the conversion of benzaldehyde. For this experiment‚ the microscale techniques of reflux‚ crystallization‚ and melting-point determination were used. Utilizing these techniques a product yield of 93% for benzil and 57% for Benzilic acid was obtained‚ as well as a melting point range of
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Introduction This lab’s purpose was to determine whether Salicylic Acid made from methyl salicylate is the same as Salicylic Acid made from benzene. This information can be found by comparing the difference in melting points of the two samples of Salicylic Acid. Here are the physical properties of Salicylic Acid and the mechanism of reactions that occurred in this lab. How Salicylic Acid is derived: Procedure/Results First‚ .26mL of 2.0mmol methyl Salicylate was measured and put
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isomers of α-phenylcinnamic acid. This was accomplished by refluxing benzaldehyde‚ phenylacetic acid‚ acetic anhydride and triethylamine as a base. The chemical equation of a Perkin Reaction can be seen below. The reaction mechanism for the synthesis of α-phenylcinnamic acid is shown below: Results: Theoretical Yield Therefore‚ phenylacetic acid is the limiting reagent. Table 1. Literature and actual IR values of (E) and (Z) isomers of α-phenylcinnamic acid. Compound Literature
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#15 Synthesis of Ethyl Salicylate from Salicylic Acid ____________________________________________________________ _______________ Purpose: Salicylic acid is converted to the liquid ethyl salicylate by addition of ethanol. Yields of salicylic acid (week 1) and ethyl salicylate will be found‚ as well as the overall yield of the 2-step conversion of acetyl salicylic acid to ethyl salicylate. Introduction: Esters are formed from the reaction of acids and alcohols: O O
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Report Written: 08/02/2009 Synthesis of Acetyl salicylic acid (Aspirin) Abstract Introduction: The following report contains information on how to produce aspirin. The experiment has been carried out on a small laboratory scale. The experiment starts by combining such chemicals such as salicylic acid and acetic anhydride. The synthesis of aspirin is classified as an esterification reaction. This is a substitution reaction where the alcohol group from salicylic acid reacts with ascetic anhydride
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