High Performance Liquid Chromatography Analysis of Aspirin Problem: Was aspirin (acetylsalicylic acid) successfully synthesized? Are there impurities or by-products present in the synthesized aspirin? How pure is the synthesized aspirin? Introduction: In the last experiment‚ aspirin was synthesized followed by characterization of the product using several different techniques. Melting point was a test that provided information about the identity and purity of the aspirin product. The iron(III)chloride
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Examples of synthesis reactions: 1. Metal + oxygen → metal oxide EX. 2Mg(s) + O2(g) → 2MgO(s) 2. Nonmetal + oxygen → nonmetallic oxide EX. C(s) + O2(g) → CO2(g) 3. Metal oxide + water → metallic hydroxide EX. MgO(s) + H2O(l) → Mg(OH)2(s) 4. Nonmetallic oxide + water → acid EX. CO2(g) + H2O(l) → ; H2CO3(aq) 5. Metal + nonmetal → salt EX. 2 Na(s) + Cl2(g) → 2NaCl(s) 6. A few nonmetals combine with each other. EX. 2P(s) + 3Cl2(g) →
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“The Synthesis of Zinc Chloride”‚ what a peculiar name for a lab that does not even involve synthesis. Synthesis‚ by definition‚ is when two elements are combined in a chemical reaction‚but that is not the case. In this lab we are combining zinc‚ an element‚ and hydrochloric acid‚ a compound‚ but combining a compound and an element is not synthesis‚ it is single replacement. We are taking zinc and hydrochloric acid and making zinc chloride and hydrogen‚ a single replacement‚ but what occurred during
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Investigative question: how are esters formed ? Esters are formed by the reaction of an alcohol and a carboxylic acid‚ usually in the presence of sulphuric acid to catalyse the process‚ or by the reaction of an acyl chloride with a carboxylic acid (this requires no catalyst and is irreversible without additional reactants) are the most common ways used. Others include reactions of certain molecules such as structural rearrangement. Apparatus: Plastic dropping pipettes‚ Beaker (100 cm3 or 250
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system to isolate the alum. 2 Al(s) + 2 KOH + 22 H2O + 4 H2SO4 → 2 KAl(SO4)2●12H2O(s) + 3 H2(g) Its composition was analyzed using two precipitation tests and two flame tests. Three methods for growing crystals were then set up for observation next lab. Theoretical yield and percent yield: The theoretical yield for alum was 4.55g and the percent yield was 139%. The percent yield was above 100% because the alum was saturated with ethanol and water. KOH test: The KOH test identified the presence of
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Materials & Methods Synthesis Procedure of PDA@MT Polydopamine is synthesized through covalent polymerization similar to melanin biosynthesis‚ with DA oxidized to dopamine quinone‚ then further oxidized to DHI‚ which undergoes deprotonation and cross-linking via Michael addition to form PDA. A solution was prepared to synthesize PDA by mixing 90 mL of water‚ 40 mL of ethanol‚ and 3 mL of ammonia solution in a 300 mL beaker. After stirring for 30 minutes at 37°C‚ a solution of 500 mg of DA dissolved
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CHEM 1474-E01 Chemistry for Everyday WEEK5 Lab Report Spring 2017 Instructor: Kyoung Nan Kim Office: SI3076 Email: kyoung.kim@ucdenver.edu Office hour: M/W 1:00p-2:30p (SI3076) T/Th 12:30p-1:30p (SI3076) • All communication should be done via school email (xxxx@ucdenver.edu) • The work will be submitted through canvas assignments. You can simply upload doc/pdf files under “Lab report” assignment tap. • Review: Ch2‚ Ch3.5‚ Ch 4.2‚ Ch6.1 and Ch7.1-Ch 7.3 in your text book (21st
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dipeptide using “Fmoc chemistry”. The first part of experiment was the synthesis of L-phenylalanine methyl ester hydrochloride. The methyl ester can be synthesised by reaction of thionyl chloride‚ SOCl2 and dry methanol with L-phenylalanine under reflux condition. The peptide bond was formed later in the experiment‚ where HBTU‚ DiPEA and a solution of Fmoc-Gly-OH in DMF were added to a solution of L-phenylalanine methyl ester hydrochloride in DMF. The product formed was the protected dipeptide‚ Fmoc-Gly-Phe-OMe
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Abstract – The synthesis of 4-hydroxy-4‚4-diphenylbutn-2-one was a three week multi-step project. The steps involved protecting the ketone of ethyl acetoacetate with a ketal group‚ followed by preparation and reaction with Grignard‚ then purification by extraction and recrystallization. The yield was 78.5%‚ but there are impurities present suggested by 1H-NMR‚ IR‚ and TLC. However‚ the results do indicate the desired hydroxyketone was formed. Introduction: The purpose of this multi-step lab was to synthesize
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The Grignard Synthesis of Triphenylmethanol Organic Chemistry Lab II March 19‚ 2012 Abstract The purpose of this experiment was to synthesize the Grignard reagent‚ phenyl magnesium bromide‚ and then use the manufactured Grignard reagent to synthesize the alcohol‚ triphenylmethanol‚ by reacting with benzophenone and protonation by H3O+. The triphenylmethanol was purified by recrystallization. The melting point‚ Infrared Spectroscopy‚ 13C NMR‚ and 1H NMR were used to characterize and confirm
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