Synthesis of Aspirin Learning Goals 1. To synthesize aspirin from salicylic acid and acetic anhydride. 2. To purify the crude product by Recrystallization. Introduction Most drugs are chemical compounds which are described as "organic compounds" because they are comprised primarily of the elements carbon‚ hydrogen and oxygen. The present experiment will be the synthesis of a familiar organic compound called aspirin. The common chemical name is acetylsalicylic acid. Aspirin‚ the
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EXERCISE 11 SYNTHESIS OF ASPIRIN MARAVILLA‚ Ana Mikaela B Group 4 CHEM 40.1 1L Date performed: September 30‚ 2013 Date submitted: October 7‚ 2013 VI. RESULTS AND DISCUSSION Aspirin is prepared by the esterification of salicylic acid with acetic anhydride under acidic conditions. The phenol group in salicylic acid is replaced by a carboxyl group through electrophilic substitution. The mechanism for the reaction can be summarized
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The first synthetic sweetener‚ saccharin‚ was discovered five years prior to Dulcin. The discovery of Dulcin occurred in 1883. Approximately seven years after it’s discovery‚ J.D. Reidel‚ of Berlin‚ was able to synthesis Dulcin at a reasonable cost. Once it became possible to synthesis at a reasonable cost‚ mass production of the sweetener began. Dulcin was favored over its competitor‚ Saccharin‚ because it did not possess a bitter aftertaste. For a very brief period of time Dulcin was marketed
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Vol. 1 ACETIC ACID 115 ACETIC ACID 1. Introduction Acetic acid [64-19-7]‚ CH3COOH‚ is a corrosive organic acid having a sharp odor‚ burning taste‚ and pernicious blistering properties. It is found in ocean water‚ oilfield brines‚ rain‚ and at trace concentrations in many plant and animal liquids. It is central to all biological energy pathways. Fermentation of fruit and vegetable juices yields 2–12% acetic acid solutions‚ usually called vinegar (qv). Any sugar-containing sap or juice can
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Jennie K. Daniels Organic Chemistry 2121 11 February 2014 Synthesis of Aspirin Salicylic acid derivatives‚ or salicin‚ are found in the bark of the willow tree. In the 5th century B.C.‚ Hippocrates ground the bark into a powder‚ and later‚ the Natives Americans chewed on the bark to alleviate fever and pain1. In the 19th century‚ a German chemist by the name of Felix Hoffman wanted to find a medication that would ease
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Starting with the weight of .198 g of salicylic acid‚ the moles of the reactant was determined to be 1.43 x 10-3‚ as shown in Equation 3. The purified aspirin product was a white powder that had a weight of .140 g. The number of moles of the purified aspirin product after extraction was 7.77 x 10-4 as shown in Equation 4. These two moles calculated a chemical yield of 54.3% as shown in Equation 5. The melting point of the pure aspirin product was ranged at 117.8-125.2C as shown in Table 1.
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Folic Acid is a B vitamin‚ specifically B9. It is an essential nutrient required by the body to create healthy new cells. While we hear about it mostly in regards to pregnancy‚ it is important to understand that the need for folic acid goes even beyond this. Folic acid is essential for the body to create red blood cells which in turn prevents anemia. It is also plays an important role in the metabolism of homocysteine‚ an amino acid. The recommended dietary allowance (RDA) for all men and women
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Ribonucleic acid (RNA) is a ubiquitous family of large biological molecules that perform multiple vital roles in the coding‚ decoding‚ regulation‚ and expression of genes. Together with DNA‚ RNA comprises the nucleic acids‚ which‚ along with proteins‚ constitute the three major macromolecules essential for all known forms of life. Like DNA‚ RNA is assembled as a chain of nucleotides‚ but is usually single-stranded. Cellular organisms use messenger RNA (mRNA) to convey genetic information (often notated
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SYNTHESIS OF ESTERS USING GREEN AND NON-GREEN CHEMISTRY Abstract Esters are a class of organic compounds with the general formula RCOOR’. Ester also contributes the flavor and aromas in fruits and flowers. The esterification reactions will use in the procedure‚ which are the interaction of a carboxylic acid with an alcohol‚ aided by an inorganic acid catalyst (H2SO4). Moreover‚ the green method will not use any catalyst but using heating source instead (microwave). Based on the comparison of
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Lab Report Synthesis and Characterization of Aspirin (Acetylsalicylic Acid) The Synthesis and Characterization of Aspirin (Acetylsalicylic Acid). Summary: In this experiment‚ we produced 4.21 g of acetylsalicylic acid. Our theoretical yield was calculated to be 5.22 g. Therefore our % yield was determined to be 80.6%. The experimental boiling point range of acetylsalicylic acid was found to be 130-132° C. The true melting point of acetylsalicylic acid is 135° C‚ therefore our percent
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