INTRODUCTION: Penicillin is the basis for most of the antibiotics in the world just as aspirin is the basis for many drugs. Therefore‚ if there had been only two drugs to invent‚ it would be down to penicillin and aspirin. Hippocrates‚ the father of modern medicine lived sometime between 460 B.C and 377 B.C. Hippocrates has left historical records of pain relief treatments‚ including the use of a powder made from the bark and leaves of the willow tree to help heal headaches‚ pains and fevers.
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Organic Synthesis of Aspirin Abstract The purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid (aspirin)‚ and to become familiar with the optimum conditions needed for successful yields. Aspirin is produced from an acid catalyzed reaction between salicylic acid with acetic anhydride. The crystalline aspirin is synthesized and purified by recrystallization‚ although there is not a hundred percent yield due to sources of error. Introduction Aspirin is a
Free Aspirin Carboxylic acid Acetic acid
Synthesis of Aspirin and Oil of Wintergreen Janelle Alyssa P. Prudente De La Salle University-Dasmariñas Dasmariñas City‚ Cavite‚ Philippines ABSTRACT In this experiment‚ acetylsalicylic acid commonly known as aspirin and methyl salicylate‚ commonly known as oil of wintergreen‚ was synthesized from salicylic acid. This study will show that it is possible to show two very different organic compounds from the same common starting material. For the synthesis of aspirin‚ salicylic acid
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Microscale Synthesis of Acetylsalicylic Acid [pic] Introduction: Acetylsalicylic acid is a wonder drug par excellence. It is widely used as an analgesic (pain reliever) and fever depressant. It also reduces inflammation and may even prevent heart attacks. It has a few side effects for some people‚ yet it is safe enough to be sold without a prescription. Because it is easy to prepare‚ aspirin is one of the most inexpensive drugs available. It is produced in vast amounts. In fact‚ industry
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Organic Chemistry I LAB EXAM: FINAL BROMINATION OF BENZENE SYNTHESIS AND PURIFICATION OF BROMOBENZENE: PROCEDURE DATA TABLE Chemical Boiling point C Melting Point C Density g/mL Solubility Benzene 80.1 5.5 0.88 Slightly in H2O Toluene 110.6 -93 0.87 Slightly in H2O Bromobenzene 155-156 -30.8 1.50 Insoluble Dibromobenzene 220.40 87.31 0.96 Insoluble MATERIALS: Graduated cylinder Weight scale Buchner funnel Filter flask Rubber stopper Hot plate Thermometer Conical funnel Various
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Introduction Table of Contents Introduction Materials Chemicals Equipment Safety Containers Measuring Devices Other Equipment Procedure Synthesis of Aspirin Crystalizing the Aspirin Recrystallizing the Crude Aspirin Finding the Melting Point Range Safety Precautions Acetic Anhydride Sulphuric and Salicylic Acid Heating Observations Mass of Aspirin Synthesized Melting Point Calculations Percentage Yield Maximum Yield Crude Product Final Product Melting Range Percentage Error
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Once the aspirin is prepared‚ it is isolated from the reaction solution and then it is purified. The aspirin is insoluble in cold water‚ and it is isolated by filtering the chilled reaction solution. Purification is essential to remove any unreacted salicylic acid and acetic anhydride as well as the acetic acid product and phosphoric acid. Acetic anhydride is caused to decompose by the addition of water once the formation of aspirin is complete. C4H6O3 (Acetic anhydride) + H2O (Water) ------------------------->
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Experimental Synthesis of Aspirin and Melting Point Purity Analysis Donald Yeargin CH 222‚ Section 24221 Department of Chemistry Portland Community College Portland‚ OR Abstract The various methods available to synthesize aspirin lead to the need to examine and evaluate production efficiency and purity. The purpose of our experiment was to synthesize acetyl salicylic acid (aspirin) and then determine the relative purity of the synthesized sample by observing the melting point temperature
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Date Experiment conducted: 05/02/2009 Date Report Written: 08/02/2009 Synthesis of Acetyl salicylic acid (Aspirin) Abstract Introduction: The following report contains information on how to produce aspirin. The experiment has been carried out on a small laboratory scale. The experiment starts by combining such chemicals such as salicylic acid and acetic anhydride. The synthesis of aspirin is classified as an esterification reaction. This is a substitution reaction where the alcohol group
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b. Characterization of Aspirin B. Set – up Fig. 11.1. Suction Filtration Set – up C. Table 11.1 List of Necessary Chemicals Sample Structure Purpose Physical Properties Hazards Salicylic Acid Starting Material Appearance: white powder Molar Mass: 138.12 g/mol Melting Point: 1590C Boiling Point: 2110C Density: 1.44 g/cm3 Mildly irritating (pulmonary irritants). Harmful by inhalation‚ ingestion and through skin absorption. Acetic Anhydride
Free Aspirin Acetic acid Acetic anhydride