Introduction ESTERS are compounds derived from the reaction of a organic acid with an alcohol. Acid + Phenol/alcohol --> ester + water R--C=O + R’--OH ----> R--C=O + H2O | | C-OH C-O-R’ Esters are the compounds that give fruits their characteristic flavours and odours. ie. methyl salycilate is "Oil of Wintergreen". http://www.petrik.com/PUBLIC/library/misc/glossary_of_org_chem.htm#ESTERS Aim To synthesise the ester 3-methylbutyl ethanoate( isopentyl acetate) and to identify the product
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Aspirin Aspirin is a salicylate‚ also known as a non steroidal anti-inflammatory drug (NSAID). It is the generic name of acetylsalicylic acid and is used clinically to treat fever‚ pain and inflammation as it works by preventing the formation of prostaglandin. Prostaglandin is the active agent that is responsible for the sensitisation at the nerve endings. It can be administered orally‚ rectally or by intravenous route. (6) Benzene ring Carboxylic acid Ester Alkane Aspirin has a pKa of 3.49
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Experiment B2 Chromatography for Protein Purification Name Matric No. Group : : : Date of Expt. : GRADE : A. Learning objectives 1. 2. 3. 4. Establish chromatographic assay to determine protein concentrations in a mixture. Appreciate the importance of resolution in protein chromatography. Understand the tension between purity and yield in protein chromatography. Understand the importance of mass balance closure in protein purification. B. Introduction I. Fast Protein Liquid Chromatography
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FOUNDATION IN SCIENCE INTRODUCTION TO PRACTICAL ORGANIC CHEMISTRY – MAKING AND PURIFYING ORGANIC COMPOUNDS Stage 1 – Deciding how much reagent to use Most organic reactions do not go to completion; most reach an equilibrium position with significant quantities of reactants still remaining. In addition‚ separating the desired product from the rest of the reaction mixture‚ and then purifying it‚ will result in the loss of more of the product. The amount of product obtained expressed as a percentage
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Investigating Aspirin Aims Synthesize my own aspirin Analyse the purity of my aspirin samples (aspirin and recrystallized aspirin) compared to commercial aspirin by use of analysing melting points‚ TLC plates and colorimetry tests Investigate how pH effects the rate of hydrolysis of aspirin Background theory Making my own sample of Salicylic acid (to then be converted into Aspirin) Salicylic acid (2-Hydroxybenzoic acid) can be made by hydrolysing methyl 2-hydroxybenzoate. Oil
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Today‚ aspirin is one of the most widely used medication on this Earth and has been since its popular breakout in the late 1890s. Long before we were born there was no such thing of a medication called aspirin. Instead‚ ancient people used willow leaves and bark from trees to help relieve oneself from pain and fevers. Aspirin as we come to know it in the form of an acetylsalicylic acid‚ was introduced to the world by Chemist Felix Hoffmann who was working at Bayer pharmaceutical company located in
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October 17 & October 24‚ 2012 How is Aspirin Made? This lab is about synthesizing aspirin using a hotplate to heat the reaction. It involved vacuum filtration‚ recrystallization‚ and comparing the properties of aspirin with salicylic aspirin. The first thing we did in this lab was make a hot-water bath by putting a beaker with water on a hot plate. After measuring out 2.1 grams of salicylic acid and 3 ml of acetic anhydride‚ we mixed the two together‚ along with 3 drops of sulfuric acid. We
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Darnell Shaw Lab Extra Credit Hippocrates of Cas (460-377 B.C.)‚ The Healer‚ noted that chewing leaves of willow (Salix) reduced pain‚ and he prescribed this remedy for women in labor. The Healer certainly did not discover this drug‚ which was used for centuries earlier in European folk medicine. Ancient Egyptians took an infusion of dried myrtle leaves to treat muscle pain. The myrtle leaves were also found to contain salicylic acid. Two Italians‚ Brugnatelli and Fontana‚ had in fact already
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EUROPEAN PHARMACOPOEIA 5.0 Acetylsalicylic acid TESTS Appearance of solution. Dissolve 1.0 g in 9 ml of alcohol R. The solution is clear (2.2.1) and colourless (2.2.2‚ Method II). Related substances. Examine by liquid chromatography (2.2.29). Prepare the solutions immediately before use. Test solution. Dissolve 0.10 g of the substance to be examined in acetonitrile for chromatography R and dilute to 10.0 ml with the same solvent. C. N‚N′-diacetyl-L-cystine‚ Reference solution (a).
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Study of Water Purification Methods Water is the most essential component of life on Earth. In the United States‚ the average person uses about 75 gallons per day of freshwater. Most of this water is pre-treated in facilities and comes out of the tap clean and ready for drinking‚ a fact many take for granted. If you are camping and hiking you won’t always have access to this source of healthy‚ potable water. Unfortunately‚ many water sources in the wilderness include microorganisms‚ bacteria
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