Name Period Date The Synthesis of Aspirin Background Pharmaceutical research labs perform chemical reactions between organic molecules that contain mostly carbon. Since the atoms in organic molecules tend to be nonmetals‚ then the bonds that hold them together are covalent bonds. Only a few elements on the periodic table are nonmetals: C‚ N‚ O‚ S‚ Cl‚ and F. This small number of elements can be bonded together in different quantities‚ bonding types (single‚ double‚ triple bonds)‚ and structural
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1 Intermediate Chemistry Laboratory I Institute of Chemistry University of the Philippines‚ Diliman I. Synthesis of Salicylic Acid Purpose: Part I of the experiment illustrates the base hydrolysis of an ester‚ methyl salicylate‚ to form salicylic acid through nucleophilic acyl substitution. Procedure: Dissolve 12 g NaOH in 70 mL water in a 150 mL round bottom flask. Add 5.0 mL methyl salicylate and reflux the reaction mixture at its boiling point for 15 minutes using a stirrer hotplate and stirring
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isomers of α-phenylcinnamic acid. This was accomplished by refluxing benzaldehyde‚ phenylacetic acid‚ acetic anhydride and triethylamine as a base. The chemical equation of a Perkin Reaction can be seen below. The reaction mechanism for the synthesis of α-phenylcinnamic acid is shown below: Results: Theoretical Yield Therefore‚ phenylacetic acid is the limiting reagent. Table 1. Literature and actual IR values of (E) and (Z) isomers of α-phenylcinnamic acid. Compound Literature
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We performed two procedures in which we reduced methyl acetoacetate. For the first procedure we produced a racemic mixture of Methyl (S)-3-Hydroxyacetate and Methyl (R)-3-Hydroxyacetate. For the second we produced only one of the enantiomer products depending on which enantiomer of Tartaric Acid was used. A reduction is a reaction which generally means adding more carbon-hydrogen bonds to a compound. In a reduction reaction the oxidation number of a carbon atom decreases. The opposite is an oxidation
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VASAMID U~ A C R Co.‚ PBARLIVER‚X. Y . ] &Butyl Esters of Amino Acids and Peptides and their Use in Peptide Synthesis1 BY GEORGEv. ANDERSON i A ND FRANCIS. C.4LLAHAN M R ECEIVED NOVEMBER 1959 30‚ T he s ynthesis of t-but)-1 esters of amino acids and peptides and their use in peptide synthesis is described. T h e most convenient method was the acid-catalyzed reaction of isobutylene with benzyloxycarbonylamino acids or peptides followed by catalytic hydrogenation to produce the basic
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Formal Report no. 1 Synthesis of Aspirin Chemical Principles Aspirin is most widely sold over-the-counter drug. It has the ability to reduce fever (an antipyretic)‚ to reduce pain (an analgesic)‚ and to reduce swelling‚ soreness‚ and redness (an anti-inflammatory agent). Much of this is believed to be due to decreased production of prostaglandins and thromboxanes. Aspirin’s ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX)
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Lab 1: Synthesis of Aspirin Introduction: The purpose of this lab was to demonstrate the ability to easily alter the molecular structure of a compound to greatly increase its utility. In this case‚ an acetyl group was added to salicylic acid‚ a naturally occurring compound with significant pharmaceutical value. Without the addition of the acetyl group‚ salicylic acid is an irritant to the gastro-intestinal (GI) tract. Once the acetyl group is added via a simple reaction‚ acetylsalicylic
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Sypnopsis In this experiment‚ acetylsalicylic acid was synthesized from the acidification of salicylic acid and acetic anhydride. The objective was to convert a specific amount of salicylic acid into the same amount of aspirin that was high in purity. Furthermore‚ the other objectives were to enable students to conduct the synthesis of aspirin‚ reinforce skills or recrystallisation and the technique of melting point determination. The amount of each compound should be the same because there is
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Synthesis of Aspirin Learning Goals 1. To synthesize aspirin from salicylic acid and acetic anhydride. 2. To purify the crude product by Recrystallization. Introduction Most drugs are chemical compounds which are described as "organic compounds" because they are comprised primarily of the elements carbon‚ hydrogen and oxygen. The present experiment will be the synthesis of a familiar organic compound called aspirin. The common chemical name is acetylsalicylic acid. Aspirin‚ the
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EXERCISE 11 SYNTHESIS OF ASPIRIN MARAVILLA‚ Ana Mikaela B Group 4 CHEM 40.1 1L Date performed: September 30‚ 2013 Date submitted: October 7‚ 2013 VI. RESULTS AND DISCUSSION Aspirin is prepared by the esterification of salicylic acid with acetic anhydride under acidic conditions. The phenol group in salicylic acid is replaced by a carboxyl group through electrophilic substitution. The mechanism for the reaction can be summarized
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