Lupus: When the Body Attacks Cassandra E. Gilles Fortis College (Miami‚ FL) Abstract Systemic Lupus Erythematosus also known as Lupus or SLE for short is a long-term chronic inflammation autoimmune disease. The cause is unknown but research suggests that both genetic and environmental factors are involved. Predispositions such as race‚ gender and age increase the likeliness of being diagnosed with lupus. Lupus is difficult to diagnose because the common signs and symptoms seem to mimic other
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Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease (1) characterized by a breakdown of B and T cells tolerance to self-antigens (2). Defective clearance of apoptotic cells could promote the release of autoantigens which in turn trigger autoimmune responses(3‚ 4). Generated immune dysfunctions lead to the production of abundant of autoantibodies and inflammatory cytokines(5‚ 6). SLE can affect various organs of the body‚ on people of both sexes‚ all ages and all ethnic
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Systemic Lupus Erythematosus Systemic Lupus Erythematosus‚ or often called lupus‚ is an autoimmune disorder that affects the skin‚ joints‚ kidneys‚ brain‚ and other organs. Lupus is a chronic inflammatory disease that happens when your body’s immune system attacks its own tissues and organs. Lupus can be difficult to diagnose because of the signs and symptoms often mimic other diseases. The most distinct sign of lupus is a facial rash that resembles a butterfly unfolding across both cheeks.
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Systemic Lupus Erythematosus Systemic lupus erythematosus‚ often known simply as lupus or abbreviated to SLE‚ is a systemic autoimmune disease or an autoimmune connective tissue disease that can affect any part of the body. As occurs in other autoimmune diseases‚ the immune system attacks the body ’s cells and tissue‚ resulting in inflammation and tissue damage. It is a hypersensitivity reaction of the type III variety‚ caused by antibody-immune complex formation. There are several explanations
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Introduction Systemic Lupus Erythematosus (SLE) is an autoimmune disease that composes many factors that contribute to the manisfestations of SLE. These factors include genetic and epigenetic regulation of gene expression‚ environmental factors‚ hormones‚ and a dysfunction in the immune system. It is estimated that about 1.5 million patients‚ and many other patients worldwide‚ have lupus. The survival rate of SLE patients improved from 50 % to 90% over the last 40 years from an estimated 5-year
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negative-trace. PATIENT VALUE: 4+. SIGNIFICANCE: A higher than normal level of protein in the urine indicates renal dysfunction. In this case‚ it suggests that the glomeruli are damaged and cannot prevent protein from exiting the blood and entering the urine ("Lab tests online‚" 2009). This finding is not uncommon among patients with systemic lupus erythematosus (SLE) because antibody-antigen complexes accumulate in the glomeruli leading to inflammation and tissue damage (McCance & Huether‚ 2006)
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INTRODUCTION: - Systemic lupus erythematosus (SLE) is an autonomous disorder with variety of autoantibodies (double stranded DNA [dsDNA]‚ ANA). It causes inflammation diffusely through the body (skin‚ brain‚ kidneys‚ and joints) and also the blood. Lupus has varied abnormal blood tests related to it (anemia‚ anti-Sm‚ anti-phospholipid antibodies)‚ however this is often not a similar issue as knowing what causes lupus. Its cause could be a mystery. The etiology of lupus is unknown‚ however multiple
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Systemic Lupus Erythematosus Treatments Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. It harms the skin‚ joints‚ kidneys‚ lungs‚ nervous system‚ and the serous membranes (Specchia et al‚ 2014‚ p.1). The symptoms in patients most commonly involve a mixture of skin conditions that affect one’s muscles‚ bones‚ and joints. Furthermore‚ SLE can have blood and blood serum symptoms. Women are more commonly affected than men‚ and the disease is diagnosed in patients aged
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Systemic Lupus Erythematosus (SLE) is an autoimmune heterogenous disease‚ meaning it is caused by many genes and alleles and variations of those genes. According to the Journal of Rare Diseases‚SLE is characterized by the presence of autoantibodies against nuclear antigens (1). An estimated 1 per 1000 individuals are affected overall‚ qualifying SLE as a rare disease. Females are more affected at a female to male ratio of 10:1. Researchers believe that‚ as many females become susceptible during pregnancy
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What is Systemic Lupus Erythematosus (S.L.E) Systemic Lupus Erythematosus is a chronic autoimmune disease which causes inflammation of your joints‚ tissues‚ and organs. The inflammation presents itself as heat‚ pain‚ swelling and redness. SLE is a variable disease that doesn’t take any one particular course; therefore its unpredictability makes it even more devastating. No two people will experience the same disease symptoms or severity level. As S.L.E progresses there will be periods of
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