Dose Adjustments in Patients with Impaired Renal Function Prof. Hartmut Derendorf University of Florida Chronic Kidney Disease Major world-wide health concern In US number of patients requiring dialysis or transplant is projected to increase from 340‚000 in 1999 to 651‚000 in 2010 National Kidney Foundation-attempts to standardize definition‚ stages and laboratory tests to assess kidney function Am J Kidney Dis. (2000) 366 suppl 2:S1–S279 S-M Huang et al. Clinical Pharmacology & Therapeutics
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Topic 2 – Cell membranes Reading Chapter 5 Objectives Functions of cell membranes The fluid mosaic model The lipid bilayer – phospholipids‚ glycolipids and sterols Properties of the lipid bilayer Membrane proteins – the ‘mosaic’ in the model Solute movements across membranes BIO 1140 – SLIDE 1 http://www.nikonsmallworld.com/gallery/year/2006/id/751 Functions of cell membranes – an overview Fluid mosaic model Singer & Nicolson 1972 Fluid lipid molecules in which
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substances across a semipermeable membrane to gain a better understanding of how cells move materials across cell membranes. The experiment was designed to exhibit Brownian Motion; the random movement and tendency of particles of a substance to move from an area of greater concentration to lower concentration via diffusion until equilibrium has been attained. In addition to observing the passive process of diffusion‚ the experiment demonstrated how a semipermeable membrane will only allow certain substances
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Marine Organism Introduction( By Elaine) Good morning‚ everyone. We are very honored to stand here to make this presentation. Firstly‚ I’d like to introduce our partners to you. This is our group leader Diao‚ and this is A‚ B‚ C‚ D‚ E. Today we are going to talk about the marine organism. Firstly let`s guess what it is ‚ok ‚let me tell you ‚it`s a kind of jellyfish‚and its name is Bougainvillia superciliaris. You may know that 71% of the earth is ocean‚ but you may not know how many
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Cell Membrane Transport Cell Membrane Transport Hands-On Labs‚ Inc. Version 42-0034-00-01 Lab Report Assistant This document is not meant to be a substitute for a formal laboratory report. The Lab Report Assistant is simply a su Premium 609 Words 3 Pages Diffusion and Osmosis of Solutes and Water Across a Membrane Diffusion and Osmosis of Solutes and Water Across a Membrane Brittany Bacallao Nova Southeastern University Abstract: This experiment gave a visual understanding
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How bacteria can affect the lives of humans and other organisms Bacteria can enter the body in 3 different ways. Through the gas exchange system‚ by breathing in pathogens‚ most are trapped in the mucus lining in the lung epithelium. There are also cilia that move the mucus up the trachea and into the mouth where it is removed. However some bacteria is still able to reach the alveoli where they invade cells and cause damage. Another way it can enter the body is through the skin‚ if the skin is
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Renal Failure Kidneys are unable to remove accumulated metabolites from the blood which leads to altered fluid‚ electrolyte‚ and acid-base balance The cause may be a primary kidney disorder or secondary to a systemic disease May be acute or chronic Acute Abrupt onset and with prompt intervention is often reversible Chronic Develops slowly‚ is the end stage‚ and is not reversible Azotemia Nitrogen (protein) waste in the blood Acute Renal Failure A rapid decline in renal function with
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Renal Cell Carcinoma Cancer is the second leading cause of death next to cardiovascular disease. There are many types of cancers‚ and different stages of cancer. There are also many different treatment options available today to fight this horrible disease. There are new drugs coming out that have showed significant results in prolonging life‚ and have helped reduce the size of tumors and slow down the progression of this disease. One of the more remarkable drugs out now is the drug Sunitinib
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Title Membrane Permeability Aim To determine the effect of various chemicals and high temperature on the membrane permeability of beetroot Hypothesis Organic solvent and high temperature will destroy the cell membrane and make it permeable to the red pigment. The higher the concentration of the alcohol‚ the greater will be this effect. Principle Beetroot is the material used in this experiment to demonstrate the effects of high temperature and chemicals on the permeability of the cell membranes
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Part 1 Part 1 of the experiment investigated the effect of different temperatures on beetroot cell membranes (a type of plant cell). Through this experiment‚ the process of diffusion and osmosis was in action. Various temperatures ranging from low temperatures to high temperatures such as -5⁰C‚ 5⁰C‚ 30⁰C‚ 50⁰C and 80⁰C were used to investigate the temperature effects on beetroot cell membranes. The hypothesis predicted that the higher the temperature the darker the beetroot substance and the lower
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