Neurodegenerative Disorders: Alzheimer’s Disease 1. Amyloid Precursor Protein (APP) Alzheimer’s disease (AD) remains a major cause of senile dementia‚ which is characterised by an impairment of neuronal and synaptic function in addition to the accumulation of β-amyloid plaque and formation of neurofibrillary tangles within distinct portions of the brain (De Strooper and Annaert‚ 2000). Progression of this distinct pathology of neurodegeneration does not typically vary from patient to patient
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genetic‚ environmental‚ and age-related factors. Genetics factors cause of Parkinson’s disease through a mutation in the genes responsible for dopamine and other vital proteins. Environmental factors are thought to be associated with Parkinson’s in that exposure to certain toxins such as pesticides can play a significant role in the abnormal levels of dopamine produced. Age is also a definitive factor of the disease‚ because people under the age of 60 are rarely diagnosed (Triarhou‚
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Different types of dementia include: - Alzheimer’s disease. - Vascular dementia. - Creutzfeldt-Jakob Disease (CJD) - Biswanger’s Disease. - Fronto-temporal disease. - Dementia with lewy bodies. - Huntington’s disease. Alzheimer’s disease is described by the Alzheimer’s society as follows. “ Alzheimer’s disease first described by the German neurologist Alois Alzheimer is a physical disease affecting the brain. During the course of the disease protein plaques and tangles develop in the structure
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sources of current legal thinking on quarantine for contagious diseases. The first originates in the law of quarantine itself. The second concerns civil commitment. Quarantine laws are limited to controlling infectious diseases. Civil commitment laws govern incarceration when people are a danger to themselves or others‚ are mentally ill and unable to care for themselves‚ or present a danger to others because they spread infectious disease. Before antibiotics‚ quarantine was important in preventing
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There are two types of Alzheimer’s disease; the first is called early-onset and appear in people from 30 to 60 years old. The first type is little common. The second type is called late-onset and it appears in people after 60 years old. The most common is the second type. The causes are not really clear‚ but these include a mixture of genetic‚ environmental and lifestyle factors. Factors genetics and age cannot be controlled. In contrast‚ other factor like socialize can be changed. Besides lifestyle
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Huntington’s disease was first ever believed to be discussed in a letter by Charles Oscar Waters in 1842. In 1846 Charles Gorman noted that the disease seemed to occur in a certain region. Symptoms of the disease were described by Johan Christian in 1860. In 1872 George Huntington gave the first complete description of the disease based on his research‚ and so the disease was named after him. In 1993 the huntingtin gene was located. Huntington’s disease is caused by a defective gene. The defective
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Lyme disease is a bacterial disease that affects over 200‚000 each year. It is caused by the bacteria Borrelia burgdorferi. It is transmitted through the bite of blacklegged ticks (deer ticks). These ticks are found in grassy and wooded areas. Female nymphal or young black-legged ticks carry and transmit the Lyme disease bacteria Borrelia burgdorferi the most. Common symptoms of Lyme disease are fever‚ muscle pain‚ joint pain‚ headache‚ fatigue‚ and a characteristic skin rash called Erythema migrans
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------------------------------------------------- Alzheimer’s disease HCA/240 Veronica Brinson Mary Lou. Jenkins August 25‚ 2013 Alzheimer’s disease is a chronic progressive deterioration of the brain leading to dementia‚ incapacitation‚ and death. Dementia is a condition marked by memory loss plus a minimum of one other cognitive impairment. Alzheimer’s disease has been referred to as both the plaque of the ages and the plague of the aged. Alzheimer’s disease was so poorly understood that people
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The Masque of the Red Death is a short story written by Edgar Allan Poe. A horrible disease ravaged a kingdom and killed half of the country. The disease’s effects are gruesome to say the least. The effects of the disease were as follows: sudden dizziness‚ sharp pains‚ bleeding from the pores and finally death. All of this took place within 30 minutes‚ but it wasn’t a fast or painless 30 minutes. While this disease was destroying the kingdom the prince‚ Prospero was his name‚ locked himself and
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For a specific disease to be spread‚ all of the stars have to somehow align. The host‚ pathogen‚ and environment/vector all have to interact at the same time. The vector-borne disease triangle illustrates that without one corner‚ the transmission of the disease would not be possible. This triangle includes hosts‚ environments/vectors‚ and pathogens. Hosts are often humans‚ dogs‚ or monkeys and are fed on by a vector. Vectors usually include mosquitos‚ fleas‚ ticks‚ mites‚ and many more. The last
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