Protein function • Chapter 5.1 • Myoglobin: structure‚ O2-binding • Hemoglobin: structure‚ cooperativity in O2binding‚ Hill constant‚ allosteric interactions‚ Bohr Effect‚ BPG-binding and effect • Abnormal Hemoglobins Functions of Proteins Fibrous proteins: collagen‚ keratin‚ silk - give tensile strength‚ shelter‚ protection Globular proteins: • Storage of ions and molecules – myoglobin‚ ferritin • Transport of ions and molecules – hemoglobin‚ serotonin transporter • Defense against pathogens –
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and G.R. Oldham. “Motivation through the design of work.” Organizational Behavior and Human Performance 16 (1976): 250–279. Hall‚ B.J.‚ H. Lane‚ and J.P. Lim. “Akamai’s underwater options (A).” HBS Case No. 902-069‚ 2002. Hall‚ B.J.‚ E. Lazear‚ and C. Madigan. “Performance Pay at Safelite Auto Glass (B).” HBS Case No. 800-292‚ 2000. Holmstrom‚ B. “The firm as a subeconomy.” Journal of Law‚ Economics and Organization 9 (1999): 74–102. Holmstrom‚ B. and P. Milgrom. “The firm as an incentive system.”
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Male 72 yrs Hb 77g/l (NR 130-180) RBC 2.23 x 10¹²/l (NR 4.5-6.5) MCV 88fl (NR 76-96) WBC 98.2 x 10/l (NR 4-11) Platelets 28 x 10/l (NR 150-400) A) Calculation of PCV (packed cell volume or haematocrit) PCV = RBC (cells/l) x 10¯¹² x MCV (fl) RBC = 2.23 x 10¹²/l MCV = 88fl or 88 x 10/l PCV = 2.23 x 88 x10 PCV = 196.24/1000 PCV = 0.196 (NR 0.4-0.54) B) Calculation of MCH (mean cell volume) MCH = Hb (g/dl) x 10 RBS (cells/l) x 10¯¹² Hb = 77g/l or 7.7g/dl
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Figure 6: Imatinib The first imatinib drug synthesis was done by Zimmermann (figure 7) in 1993‚ he used a chain of the reaction to reach to imatinib but the important part is that both guanidinium nitrate 7 and aminopyrimidine 8 are precipitated from the respective reaction mixtures by the addition of Figure 7: imatinib synthesis by Zimmermann insolubilizing solvents‚ so we got a condensation reaction between guanidinium salt 7 with enone “9” to form the aminopyrimidine “8” then “8” is
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sickle-cell hemoglobin. In 1956‚ Vernon Ingram developed the technique of fingerprinting peptides in order to pinpoint the difference between HbA and HbS. center6985 Fig: oxyhemoglobin and deoxyhemoglobin center18923000 Ingram’s fingerprints of HbA and HbS revealed that their alpha subunits are identical but that their beta subunits differ by a vari- ation in one tryptic peptide. Sequencing studies eventually
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balanced to have a sustainable deficit. This is echoed by Morgan Stanley Chief Economist Stephen Roach who stated‚ “other countries must learn to grow the old fashioned way – drawing support from their home markets rather than free-riding on the US” (HBS p11). The US has run a current account deficit for over 30 years. This shows that deficits can be sustainable over time. However‚ as of 2005 and earlier‚ the US deficit has spiked to dangerous and unsustainable levels. As of 2008‚ the current account
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Fund‚ Inc (Abridge) Introduction Background of case Study Rick Melnick is an Associate Director of Financial Management at Harvard Business School (HBS). He had decision to make regarding the new funding policy under the management of Student Educational Loan Fund (SELF). SELF was established in 1961 to fund loans to HBS. Traditionally‚ HBS student loans required the borrower to pay semi-annually with variable interest rate policy. Under the new plan‚ the students would receive monthly paid
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Assignment II: Business Basics Biogen Idec Biogen Idec is a global biotechnology company focused on discovering‚ developing‚ manufacturing and marketing therapies for the treatment of multiple sclerosis and other autoimmune disorders‚ neurodegenerative diseases and haemophilia. Biogen Idec was formed in 2003 from the merger of two companies‚ Biogen Inc.‚ founded in 1978‚ and IDEC Pharmaceuticals Corporation‚ founded in 1985. It is one of the largest biotechnology companies in the world. Biogen
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[pic] IILM Institute for Higher Education Module Manual: Basics of Economics Academic Year: PGP/ 2012-2014 1. Introduction to the Module and Module Objective Executives‚ consultants‚ investment bankers and many other practitioners make daily economic decisions that explicitly or implicitly follow economic laws. ‘Basics of Economics’ give an introduction to the economics of business decision-making. It is
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Week 1 Deshpande‚ Rohit (2014). Customer Centricity‚ HBS 8171‚ Boston‚ MA: Harvard Business School. 1. a. b. c. d. e. 2. 3. 4. Select a company from the list provided below. Amazon Apple Google Trader Joe’s Starbucks Offer suggestions for how the company might become more customer centric based on the key customer-centric characteristics of successful companies‚ found on page 3 of the reading. Identify company and situational factors that may help get your ideas adopted‚ and factors that may hinder
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