PREFORMULATION STUDIES Preformulation may be described as the process of optimizing a drug through determination and identification of those physical and chemical properties considered important in the formulation of a stable‚ effective and safe dosage form. Preformulation studies focus on those physicochemical properties of the compound that could affect drug performance and development of an efficacious dosage form. These Preformulation investigations merely confirm that there are no significant
Premium Solvent Solubility
SPECTROPHOTOMETRIC DETERMINATION OF THE EQUILIBRIUM CONSTANT OF A REACTION M. L. SANGA CHEMICAL ENGINEERING‚ COLLEGE OF ENGINEERING UNIVERSITY OF THE PHILIPPINES‚ DILIMAN‚ QUEZON CITY‚ PHILIPPINES DATE PERFORMED: JANUARY 15‚ 2014 INSTRUCTOR’S NAME: MOISES JEROME GARRERO ______________________________________________________________________________________________________________________________ ABSTRACT The experiment aimed to determine the equilibrium constant Keq of the formation
Premium Chemical equilibrium Concentration
According to Stability testing of new drug substances and products‚ a guideline of ICH desires that to clarify the inherent stability characteristics of the active component stress testing was implemented. The aim of this work was to carry out the stress degradation studies on the Lamivudine‚ Abacavir and Dolutegravir using the proposed method. Formulation drug products were exposed to thermal stress‚ oxidative stress‚ photolytic‚ hydrolytic stress under acidic medium and basic medium. An ideal
Premium Chemistry Chemical reaction Water
Chapter 1 ENGINES 1.1. INTRODUCTION The term‚ Engine‚ coined from the French word Engin‚ is nothing new to engineers. Motors converting heat energy into motion are usually referred to as engines (Collins English Dictionary - Complete & Unabridged 10th Edition‚ 2010). The type of engine being focused on in this report is an Internal Combustion Engine (as shown in Fig 1.1) in which a fuel is burnt along with air to produce hot gases which are then used to generate the necessary power
Premium Internal combustion engine
Purpose The purpose of the experiment is to determine the percent yield of the precipitate; by performing double displacement reaction between solutions of two different compounds. Introduction First of all when making a solution of two different compounds; there will many variables that can be considered during the experiment. However‚ the variables are controlled variables. Controlled Variables ∙amount of water that will be dissolved with the compound (amount of water until the compound is
Premium Solubility Stoichiometry
LABORATORY REPORT SUMMARY This lab report was conducted to design Hot Mix Asphalt for a project in Fayetteville‚ Arkansas. The tests were conducted in compliance with current specifications for Superpave set forth by AASHTO and AHTD. The topics covered in the lab report are selection of materials‚ selection of mix design‚ and final recommendation. Even though other properties of the mixture just meet the Superpave design requirements‚ no job mix formula is drawn from this mix design because
Premium Construction aggregate Sieve analysis Mixture
Refrigeration Cycles Prof. U.S.P. Shet ‚ Prof. T. Sundararajan and Prof. J.M . Mallikarjuna 6.5 Simple Vapor Compression Refrigeration System: A simple vapor compression refrigeration system consists of the following equipments: i) Compressor ii) Condenser iii) Expansion valve iv) Evaporator. B COMPRESOR C ∆Q1 200C FLUID TO BE COOLED EVAPORATOR (-300C) w CONDENSER (350C) COOLING WATER 00C ∆Q2 A EXPANSION VALVE D Fig.6.5. Simple vapour compression system
Premium Thermodynamics
Title : Preparation of a standard solution Aim To prepare a standard solution of potassium hydrogenphthalate which will later be used to standardize sodium hydroxide solution‚ NaOH. Research question How does different molarity of potassium hydrogen phthalate solution which is prepared by dilution process influence the volume of sodium hydroxide‚ NaOH used during titration process until the colourless phenolphthalein indicator solution turns pink where the volume of potassium hydrogenphthalate used
Premium Chemistry Titration Sodium hydroxide
CBE 6333‚ R. Levicky 1 Potential Flow Part I. Theoretical Background. Potential Flow. Potential flow is frictionless‚ irrotational flow. Even though all real fluids are viscous to some degree‚ if the effects of viscosity are sufficiently small then the accompanying frictional effects may be negligible. Viscous effects become negligible‚ for example‚ for flows at high Reynolds number that are dominated by convective transport of momentum. Thus potential flow is often useful for analyzing external
Premium Fluid dynamics
(AgNO3) * Analytical Balance * 2- Volumetric Flasks; one 50 mL flask‚ and one 100 mL flask * 2- Scoopulas * 10- Weigh Boats * 5- Filter paper * 5- 250 mL beakers * 2- 25 mL pipets * Distilled water * 2- 100 mL Erlenmeyer flasks * 2- glass funnels Procedure: 1. To the best of your ability‚ weigh out 3.75 grams of BaCl2 and 6.125 grams of AgNO3 on separate weigh boats 2. Pour the BaCl2 into the 50 mL volumetric flask from the weigh boat 3. Then add
Premium Silver Erlenmeyer flask Laboratory glassware