Genetic Information Tay Sachs is a devastating genetic disease. There are three different forms of the disease- Early Onset which emerges around three to six months of age‚ Juvenile which mainly appears between the ages of two and five but could start anytime in childhood‚ and Late Onset which mostly presents in adolescence or early adulthood but could occur at any time. Tay Sachs is caused by a mutation--a deletion of chromosome 15. The HEX A gene on this chromosome is responsible for creating
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Tay Sachs Disease Tay Sachs disease is caused by the homozygous recessive gene on chromosome 15 that codes for the lack of production of hexosaminidase-A (Hex-A) [1]. Since there is no HexA‚ a fatty substance is allowed build up abnormally in nerve cells‚ which damages the cells and the brain [1]. Males and females are equally likely to carry this recessive gene but the heterozygous gene carriers are not affected‚ because they still have the dominant gene [2]. If both parents have the heterozygous
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Tay-Sachs Disease History: The disease is named for Warren Tay (1843-1927)‚ a British ophthalmologist who in 1881 described a patient with a cherry-red spot on the retina of the eye. It is also named for Bernard Sachs (1858-1944)‚ a New York neurologist whose work several years later provided the first description of the cellular changes in Tay-Sachs disease. Sachs also recognized the familial nature of the disorder‚ and‚ by observing numerous cases‚ he noted that most babies with Tay-Sachs
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Emma Goldman perseverance towards equal rights‚ views on women‚ and reorganizing politics especially for women earned her‚ her place in history. Emma was born in Lithuania‚ but she moved to a czarist Russian ghetto called Kovno until 1886.(“Was My Life Worth Living?”‚ 2000) Her father discouraged her from having an education‚ and he told her that her only meaning in life was marrying and having a family.(“Emma Goldman: Overview‚ 2003) She moved to New York to live with her sister Lena at the age
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America Today is More Unhappy America today is more disillusioned than back in the 1920’s. I believe that America today is more unhappy because of divorce rates‚ technology‚ and people being materialistic. Today in America everyone gets divorced now. I also believe that technology today drives people to become more distant from their family and friends. People being materialistic today in America has caused relationship problems. That is why I believe that America today is more disillusioned
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Many people in society today are having casual sex outside of the marriage more and more. Has sex lost its true purpose and morality? If so‚ is this correct and morally acceptable? Alan Goldman and Roger Scruton see sex and the morality of sex very different. Goldman believes sex is just that‚ sex between two people for pleasure while Scruton believe sex should always have love and emotion with a spouse or long term relationship. What is the true morality of sex and who is correct? Sex should
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Tay-Sachs is a devastating disease affecting lysosomal storage. According to McCance & Huether (2014)‚ it is due to a deficiency in the lysosomal enzyme hexosaminidates A (HexA) that’s function is to degrade GM2 gangliosides (fatty acids) in nerve cells. Those diagnosed with Tay-Sachs do not have the ability to degrade this fatty acid and as a result‚ it builds up in the body causing nerve cell toxicity. It is genetically inherited through an autosomal recessive pattern meaning that both parents
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CONSIDERING RISKS IN INTERNATIONAL BUSINESS Business by itself requires high awereness of risks‚ taking these risks‚ managing them and gain profits from them. The literature names this task as "entrepreneurship". Entrepreneurship is the practice of starting new organizations‚ particularly new businesses generally in response to identified opportunities. Entrepreneurship is often a difficult undertaking‚ as a majority of new businesses fail. Entrepreneurial activities are substantially different
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recognized for the leading role he has played in restructuring the steel industry towards a more consolidated and globalized model. Mittal states: “Always think outside the box and increase the opportunities that appear‚ wherever they might be” Mr. Mittal is an active philanthropist and a member of various boards and trusts‚ including the boards of Goldman Sachs and European Aeronautic Defence& Space Company (EADS) N.V. He is also a member of the
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Bell Mountain Vineyards is considering updating its current manual accounting system with a high-end electronic system. While the new accounting system would save the company money‚ the cost of the system continues to decline. The Bell Mountain’s opportunity cost of capital is 10 percent‚ and the costs and values of investments made at different times in the future are as follows: Year Cost Value of Future Savings (at time of purchase) 0 $5‚000 $7‚000 1 4‚500 7‚000 2 4‚000 7‚000 3 3‚600 7‚000
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