Abstract: This experiment synthesized H-Gly-Phe-OH dipeptide using “Fmoc chemistry”. The first part of experiment was the synthesis of L-phenylalanine methyl ester hydrochloride. The methyl ester can be synthesised by reaction of thionyl chloride‚ SOCl2 and dry methanol with L-phenylalanine under reflux condition. The peptide bond was formed later in the experiment‚ where HBTU‚ DiPEA and a solution of Fmoc-Gly-OH in DMF were added to a solution of L-phenylalanine methyl ester hydrochloride in DMF
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UNIVERSITY OF WATERLOO Department of Chemistry Synthesis of ACETAMINOPHEN Laboratory Report 1 CHEM 123L January 19‚ 2014 Prepared for: Dr. S. Stathopulos Department of Sciences‚ Chemistry Faculty University of Waterloo Teaching Assistant: Aaron Chan Prepared by: Section 001 Vithurjan Satkunarasan 20495383 Lab Partner: Ken Xu Introduction The synthesis of Acetaminophen is based on the amine group of p-aminophenol being acetylated by acetic anhydride to form an amide functional group
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A small amount of the unknown (approximately the tip of the spatula was used for all the pigments) was added into each clean dry test tube. For the first test 1 mL of 3 M of HNO3 was added. As soon as the acid came into with the solid‚ the pigment was observed to dissolve while also turning the solution into a pale clear colour. The same amount was used for the HCl reagent. As soon as the acid touched the pigment it yielded in a clear solution (solid dissolved after a few shakes). When the KI was
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synthesised is only 67%-70% and a maximum 70% yield of ester usually is not considered to be acceptable for a synthesis reaction‚ instead it is considering as a poor yield of ester. The synthesised ester can only have a maximum yield of 70% because for ester in which the carboxylic acid and alcohol are sterically unhindered‚ a same ratio mixture of carboxylic acid and alcohol can only synthesis ester with a maximum yield of 70% ester as the reaction with the same ration of mixture will reach a state
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Objective: The benefit of this lab was to acquaint oneself with the fundamentals of the Aldol Condensation reaction by demonstrating the synthesis of dibenzalacetone (trans‚ trans-1‚5-Diphenyl-1‚4-pentadien-3-one) through the aldol condensation of acetone with benzaldehyde. The synthesis began by using a strong base to generate the acetone enolate ion. The ketone/enol tautomerization is an equilibrium process that produces little of the enol (ppm or less). However‚ any enol that formed quickly reacted
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Medicine Analysis – Synthesising Aspirin results After recrystallisation differences between the crude and purified aspirin were noted. The impure (crude) aspirin was powered and fluffy with small clumps and was slightly yellow in colour whereas the pure aspirin has a less fluffy crystalline powder and was whiter. This showed distinct differences in the two substances but similarities were also apparent showing aspirin‚ in some level‚ was created. Before recrystallisation the crude aspirin could
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Synthesis As a representation of the culture of the time period‚ art enables its audience a sense of history and recollection. The pieces of work are timeless‚ precious‚ and irreplaceable‚ for they hold a significance that amazes all. Therefore‚ a museum that houses a collection of artifacts have employees who bear the responsibility of accurately securing and displaying works of arts or artifacts. When doing so‚ it is imperative for the these group of people who have the weight of the artifact’s
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Period 6 March 21‚ 2012 Synthesis Essay Conformity versus individualism is a topic that has been discussed in literature throughout the years. When people are forced to conform to society‚ they are expected to act appropriately toward society’s vision. When people stand out from the crowd‚ they create an imbalance in culture. This is why individualism is condemned in most works of literature‚ but people still attempt to defy society’s vision and make a difference. This topic is discussed
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The purpose of this experiment was to perform a wittig reaction‚ the horner-emmons wittig specifically‚ reacting an aldehyde with an ylide to make an alkene. This particular variation of the wittig reaction has several advantages: It gives only the trans product; it uses a much milder base that is easier to handle; and it gives a water soluble byproduct which is easy to separate from the product. The reason that these advantages occur is a change in the structure of the ylide. Instead of a tripheylphosphine
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Assignment 37: Synthesis Essay As Martin Buber holds “relationship of supreme importance‚” we must hold relationships and people of supreme importance. (Littlejohn & Domenici 2007‚ p. 243). People are not objects “to be changed‚ reduced and manipulated.” (Littlejohn & Domenici 2007‚ p. 243). When we start treating people as objects we are building the I-It relationship with them. (Littlejohn & Domenici‚ 2007). This type of relationship fails to move towards value because people feel mistreated
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