The purpose of this experiment was to perform a wittig reaction‚ the horner-emmons wittig specifically‚ reacting an aldehyde with an ylide to make an alkene. This particular variation of the wittig reaction has several advantages: It gives only the trans product; it uses a much milder base that is easier to handle; and it gives a water soluble byproduct which is easy to separate from the product. The reason that these advantages occur is a change in the structure of the ylide. Instead of a tripheylphosphine
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The Wittig reaction is a unique reaction that can be carried out in various ways as our prompt exemplifies. We will be primary focusing on the second of the three schemes. In The usual formation of an ylide occurs via Sn2 attack of a PR3 group on an alkyl halide‚ which is then followed by a strong base deprotonating of one of the hydrogens on the methyl which the PR3 attacked. Before we dive into the details of the reaction occurring in scheme 2 it will be important to understand the mechanism which
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Experiment 3: Wittig Reaction Introduction This experiment performs a modified Wittig reaction using a phosphorus-containing Hornes-Emmons-Wittig reagent to generate an enolate anion of trimethyl phosphonoacetate instead of a phosphorus ylide. The methyl trans-4-methoxy cinnamate produced is then analyzed using melting point and 1H NMR spectroscopy. Theory The Wittig reaction prepares alkenes from carbonyl compounds by attacking a phosphorus ylide with a nucleophilic carbon atom stabilized by
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Title: Synthesis and Reaction of halogenoalkane‚ 1-bromobutane Aim: To prepare 1-bromobutane and investigate some of its reactions Materials and Apparatus: • Eye protection • Distillation Kit • Thermometer • Measuring cylinder • Teat pipette • Rack with 3 small test tubes • Beaker Chemicals: • Butan-1-ol (harmful and flammable) • Sodium bromide • Concentrated sulphuric acid (very corrosive) • Anhydrous sodium sulphate • Concentrated hydrochloric acid (corrosive) • Ethanol
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Experiment 13: Synthesis of 1- Bromobutane An SN2 Reaction Theory: One of the methods of preparing alkyl halides is via the nucleophilic substitution reactions of alcohols. Alcohols are inexpensive materials and easy to maintain. However‚ they are a poor leaving group the OH group is a problem in nucleophilic substitution‚ this problem is fixed by converting the alcohol into H2O. Objective: The objective of this lab is to observe the synthesis of 1-bromobutane in an SN2 reaction‚ to see how a
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through the reaction mechanism recognized as the Wittig Reaction. The Wittig Reaction allows the chemist to synthesize phosphoranes in the lab with relative ease. A more recent and inexpensive version of the reaction is the Wittig-Horner reaction (1). ABSTRACT Georg Wittig was a German chemist and Nobel Prize winner in 1979 for the Wittig reaction (1). He was born in Berlin‚ on June 16‚ 1897‚ and died August 26‚ 1987 (1). Wittig discovered the route to alkenes through ylide molecules (1). Wittig was educated
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alcohol 1‚2-diphenyl-1‚2-propanediol‚ through an addition reaction pathway. Introduction: Grignard reagents are alkyl or aryl-magnesium halides that act as the nucleophile in Grignard reactions‚ where ketones are reacted with the reagent‚ then treated with acid to produce an alcohol. In the case of this experiment‚ methylmagnesium iodide was created from methyl iodide and magnesium metal. It acted as the Grignard Reagent in Part B upon which it was reacted with benzoin to create 1‚2-diphenyl-1‚2-propanediol
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Discovered by Georg Wittig in 1954‚ the Wittig reaction is a robust organic synthesis method for preparing stereospecific alkenes. In general‚ Wittig reactions involve an aldehyde or ketone and a Wittig reagent (triphenylphosphonium ylide) and result in the formation of an alkene product and triphenylphosphine oxide (side product). Stereospecific alkene products can be synthesized by adjusting the reaction reagents and conditions. In the 60 years since the Wittig reaction was discovered‚ many articles
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GRADUATE SCHOOL MASTER IN BUSINESS ADMINISTRATION SYNTHESIS NO.1 (MODULE NO. 1-3) HUMAN RESOURCE MANAGEMENT Submitted by: WILLIAM L. BERMEJO MBA-1 Submitted to: MS. ESTELA MARIE O. VERANA‚ D.M. Professor November 23‚ 2013 In the first session‚ we learn deeply and discuss the overview of human resource management. Human resource management (HRM‚ or simply HR) is the management process of an organization’s workforce‚ or human resources. It is responsible for the attraction‚ selection‚ training
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The task of preforming a biblical exegeses of Philippians 4:1-9‚ mean exploring ““associative” concepts in the letter‚ for example‚ the emphasis on friendship and Paul’s close ties to this Church” (Willis). This task cannot be accomplished without examining the author‚ audience and culture surrounding the text. In the detailed analysis of this letter‚ we will examine the benefits of Christians remaining like-minded in Christ and the impact it has on the church. Paul used this letter to the Philippians
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