A Summary Of Influenza Virus
Influenza virus is one of the well-explored the pathogens and development of flu vaccine is considered as the most efficient strategy to defense the outbreak. However, the variability of the antigen and rapid reassortant of the genetic segments weakens flu vaccine effectiveness. And the protection of flu vaccine could not contribute to clinical treatment when the patients suffer from severe illness. Therefore, the study of the interaction between pathogen and host immune response is needed. The Hannover Medical School has outstanding researches in innate immunity and infectious disease. With the high-profile research environment and proper advice from the faculty, I will accomplish my studies to solve the puzzle of the viral pathology.
Acute
inflammatory syndrome, such as high fever and pneumonia, is the main cause of respiratory dysfunction, even deaths. The aberrant immune response is a feature shared by patients with severe illness. However, how influenza viruses disrupt the immune regulation is still unclear. Genome-wide screens of host responses during influenza infection give a map to explore the complex network, but it still should be proved from in vitro to in vivo. I have practical experience of immunology and animal experiments in BSL-3 to support the studies. Signal transduction and influenza protein are also the focuses in my master thesis. By comparing the viral protein among strains, I think it is possible to identify an underline mechanism of the aberrant immune response caused by influenza virus.
I have confidence in my working experience in infectious disease and animal experiment and want to continue my study in virology research. Prof. Herrler’s discoveries and advanced techniques on glycoprotein and host adaption of influenza contribute to study the virulence assessment of novel flu viruses. Another research teams also have important contribution in immune and viral studies. HBRS program allows me to accomplish the further studies in the future.
Acute
inflammatory syndrome, such as high fever and pneumonia, is the main cause of respiratory dysfunction, even deaths. The aberrant immune response is a feature shared by patients with severe illness. However, how influenza viruses disrupt the immune regulation is still unclear. Genome-wide screens of host responses during influenza infection give a map to explore the complex network, but it still should be proved from in vitro to in vivo. I have practical experience of immunology and animal experiments in BSL-3 to support the studies. Signal transduction and influenza protein are also the focuses in my master thesis. By comparing the viral protein among strains, I think it is possible to identify an underline mechanism of the aberrant immune response caused by influenza virus.
I have confidence in my working experience in infectious disease and animal experiment and want to continue my study in virology research. Prof. Herrler’s discoveries and advanced techniques on glycoprotein and host adaption of influenza contribute to study the virulence assessment of novel flu viruses. Another research teams also have important contribution in immune and viral studies. HBRS program allows me to accomplish the further studies in the future.