There are some main stages of the whole history and background information. In 1851, Dr. Emst Christian Friedrich Schering begins developing and selling pharmaceutical products in Berlin. Three years later, the company opened its first production facility. In 1891, Merck&Co. emigrated to the United States and the U.S. subsidiary's parent company, E.Merck, was originally founded in Darmstadt, Germany, in 1668. In 1953, Merck merged with Philadelphia-based Sharp & Dohme, Inc., founded by Alpheus Phineas Sharp and Carl Friedrich Louis Dohme in 1845, becoming the largest US drugmaker. In 1982, Merck entered into an agreement with Astra AB (“Astra”) to develop and market Astra products under a royalty-bearing license.In 1994, Merck and Pasteur Mérieux Connaught (now Sanofi Pasteur S.A.) formed a joint venture to market human vaccines in Europe and to collaborate in the development of combination vaccines for distribution in the then-existing EU and the European Free Trade Association.And in 2000, Merck and Schering-Plough establish joint ventures in the United States to develop and market new prescription medicines in the cholesterol management and respiratory areas. Then they combine to build on a shared legacy of scientific excellence, customer focus, and innovation. ( Page 1)
The Company’s ability to generate profits and operating cash flow depends mostly upon the continued profitability of the Company’s key products, such as Singulair, Januvia, Remicade, Zetia, Vytorin, Janumet, Isentress, Nasonex, Gardasil, and Temodar. The Company sells human health pharmaceutical products primarily to drug wholesalers and retailers, hospitals, government agencies and managed health care providers such as health maintenance