The protagonist Andrea Sachs is a fresh graduate from college who surprisingly lands up in a job as assistant to editor-in-chief Miranda Priestly at fashion's top-notch Runway magazine. Though she knows nothing about fashion, she is told that it would be a stepping stone to any job in the publishing world once she gets a review from Miranda on completion of her first and only year at Elias-Clark.
The book has described in great details the errands 'Aan-dre-aah' has to run for her boss. It describes her hectic schedule and the minute but many demands of her difficult to please boss. Andrea endures verbal abuse, running mundane errands for Miranda, party planning, babysitting, and feeling for herself throughout the narrative. Her family, best-friend Lily and boyfriend Alex are neglected by her and are distanced as she starts to become more occupied in the fashion world.
She ends up flying with Miranda to Paris for a fashion week. In Paris, she has a surprise encounter with Christian. Later that night, Miranda finally lets down her guard and asks Andrea what she had learnt, and where she would like to work after her stint at Clark. She promises to place phone calls to people she knows at The New Yorker on Andrea's behalf once her year is up and suggests that she take on some small writing assignments at Runway.
Back at the hotel, Andrea gets urgent calls from Alex and her parents asking her to call them. She does so and learns that Lily is in coma after driving drunk and wrecking a car. Though Andrea is pressured by her family and Alex to return home, she tells Miranda she will honor her commitment to Runway. Miranda is pleased, and tells her that her future in magazine publishing is bright. At the Paris fashion show for Christian Dior, however, Miranda reaches her with yet another impossible demand. Andrea finally realizes that her family and friends are more important than her job, and that to her horror she had been becoming more and more like