Cardiovascular Disease (AIHV)
1 Background (750)
Just over one in five adult Australians (22%) report having at least one form of cardiovascular disease (CVD) [AIHW]. All statistical information on the prevalence of CVD relies on self-report measures, meaning those with mild forms who have not yet sought treatment and those with an inability to adequately report their own health are not properly represented. The self-report survey used, did not include any people living in care facilities, and since CVD is most common in individuals over the age of 75, assessments of CVD incidence and prevalence may be severely underestimated [AIHW].
1.1 Heart failure (HF) and the Paraventricular Nucleus (PVN)
The PVN is heavily involved in sympathetic regulation and outflow which has effects on cardiovascular functions such as arterial pressure and heart rate [Nishi, Stocker, Zucker]. A higher activation of the PVN than normal, along with reduced nitric oxide …show more content…
Exact progression and expression of HF will vary considerably between individual patients, and should differential results of efferent RDN (eRDN) and afferent RDN (aRDN) arise, it may be possible to increase procedural efficiency by tailoring treatment to the individual [Floras].
1.4 Aims and Hypotheses
We aim to identify the specific effects of aRDN and eRDN on activity of the PVN and further to discover if either of these procedures produce more favourable, or equally as favourable, results than whole RDN. We hypothesise that overall PVN activation, as measured by FosB expression would best be reduced by whole RDN, that Angiotensin II (AngII) would best be reduced by eRDN, and that neuronal NOS (nNOS; levels of which are indicative of levels of nitric oxide) would best be increased by eRDN.
2 Methods (625)
2.1 Research Design
75, 2 month old, male, Sprague-Dawley rats of average weight will be acclimatised to laboratory settings then randomly allocated to 1 of 5 groups: HF, no HF (nHF), HF+eRDN, HF+aRDN, HF+RDN (n=15,
Just over one in five adult Australians (22%) report having at least one form of cardiovascular disease (CVD) [AIHW]. All statistical information on the prevalence of CVD relies on self-report measures, meaning those with mild forms who have not yet sought treatment and those with an inability to adequately report their own health are not properly represented. The self-report survey used, did not include any people living in care facilities, and since CVD is most common in individuals over the age of 75, assessments of CVD incidence and prevalence may be severely underestimated [AIHW].
1.1 Heart failure (HF) and the Paraventricular Nucleus (PVN)
The PVN is heavily involved in sympathetic regulation and outflow which has effects on cardiovascular functions such as arterial pressure and heart rate [Nishi, Stocker, Zucker]. A higher activation of the PVN than normal, along with reduced nitric oxide …show more content…
Exact progression and expression of HF will vary considerably between individual patients, and should differential results of efferent RDN (eRDN) and afferent RDN (aRDN) arise, it may be possible to increase procedural efficiency by tailoring treatment to the individual [Floras].
1.4 Aims and Hypotheses
We aim to identify the specific effects of aRDN and eRDN on activity of the PVN and further to discover if either of these procedures produce more favourable, or equally as favourable, results than whole RDN. We hypothesise that overall PVN activation, as measured by FosB expression would best be reduced by whole RDN, that Angiotensin II (AngII) would best be reduced by eRDN, and that neuronal NOS (nNOS; levels of which are indicative of levels of nitric oxide) would best be increased by eRDN.
2 Methods (625)
2.1 Research Design
75, 2 month old, male, Sprague-Dawley rats of average weight will be acclimatised to laboratory settings then randomly allocated to 1 of 5 groups: HF, no HF (nHF), HF+eRDN, HF+aRDN, HF+RDN (n=15,