Cleome Rutidosperma Research Paper

The hypoglycaemic and antihyperglycaemic effects of methanol extract of the leaves of Cleome rutidosperma (Cr) DC (Family: Capparidaceae) was investigated in Wistar rats. Fifty normoglycaemic male rats (120g-200g) were divided into groups A (hypoglycaemic study; n=20) and B (antihyperglycaemic study; n=30).
The studies had one control group and three groups administered with Cr (100, 200 or 400mg/kg) respectively. Group B had two additional groups of diabetic-untreated rats and glibenclamide-treated diabetic rats. Diabetes was induced in Group B rats (except control) fasted overnight for 12hours by intraperitoneal injection of Alloxan (100 mg/kg body weight). Initial fasting blood glucose levels (FBGL) were determined and alloxan-treated rats
Cleome rutidosperma (Family: Capparidaceae), commonly known as fringed spider flower or purple Cleome, a native of Tropical Africa and found as garden weed in Asia and Australia is one of such medicinal plants. The leaves are prepared as hot water infusion or chewed whole for management of DM. A dearth of information exists on scientific verified of this pharmacological effect. This study was therefore designed to investigate the hypoglycaemic and antihyperglycaemic effects of methanol extract of the leaves of C. rutidosperma in normoglycaemic and alloxan induced hyperglycaemic Wistar rats at dose levels of 100, 200 and 400 mg/kg, p.o.
Rats in group 1 served as the control for this experiment. Cr extract was administered to rats in groups 2, 3 and 4 at doses of 100, 200 or 400mg/kg respectively. The rats were fasted overnight (12hours) before the commencement of the hypoglycaemic study and the fasting blood glucose levels were determined. The extract was administered, rats were fed and blood glucose levels (BGL) were monitored using a glucometer (AccuChek active®) at 1, 2, 3, 6, 12 and 24 hours post-feeding with commercially available rat pellets to determine the hypoglycaemic effect of