Of course there are the physical differences between the House and Senate. The Senate seats 100 Senators, two from each state, and the House seats 435 based on state population. Senators stay in office for six years and must be at least 30 years old, where as a Congressman is elected for 2 years and at least 25 years old. But putting numbers aside both a Senator and a Congressman have two completely different jobs. The House was created to initiate the American political process. This is where all laws begin their journey to ratification to the Constitution. Unlike the Senate, the House has power less equally distributed. The strongest person in the House is of course the Speaker of the House. Then there are the individual whips and lower positions of power. In the Senate the power is more equally distributed since there are only 100 members, although party control is still important, it isn't as important or defined as it is in the House of Representatives.
The similarities between each organization are less defined and few and far between. Both houses are elected by their people, the Congress has more local support since they are supposed to represent their smaller districts. Members of either House must live in their represented states. The Senators are elected by the state as a whole. In terms of jobs, both Houses create committees to address certain issues. Some committees exist in both Houses such as the budget and judiciary