Concentration, Chlorination, and Chemical Analysis of Drinking Water for Disinfection Byproduct Mixtures Health Effects Research: U.S. EPA’s Four Lab Study
Environ. Sci. Technol. 2010, 44, 7184–7192
Concentration, Chlorination, and
Chemical Analysis of Drinking Water for Disinfection Byproduct Mixtures
Health Effects Research: U.S. EPA’s
Four Lab Study
JONATHAN G. PRESSMAN,†
S U S A N D . R I C H A R D S O N , * ,‡
THOMAS F. SPETH,†
RICHARD J. MILTNER,†
MICHAEL G. NAROTSKY,§
E. SIDNEY HUNTER, III,§
GLENN E. RICE,| LINDA K. TEUSCHLER,|
ANTHONY MCDONALD,§
SHAHID PARVEZ,| STUART W. KRASNER,⊥
HOWARD S. WEINBERG,#
A. BRUCE MCKAGUE,∇
CHRISTOPHER J. PARRETT,†
N A T H A L I E B O D I N , #,O R U S S E L L C H I N N , ⊥
CHIH-FEN T. LEE,⊥ AND
JANE ELLEN SIMMONS§
National Risk Management Research Laboratory, U.S. EPA,
Cincinnati, Ohio 45268, National Exposure Research
Laboratory, U.S. EPA, Athens, Georgia 30605, National Health and Environmental Effects Research Laboratory, U.S. EPA,
Research Triangle Park, North Carolina 27711, National
Center for Environmental Risk Assessment, U.S. EPA,
Cincinnati, Ohio 45268, Metropolitan Water District of
Southern California, La Verne, California 91750, Gillings
School of Global Public Health, Department of Environmental
Sciences and Engineering, University of North Carolina,
Chapel Hill, North Carolina 27599-7431, and CanSyn Chem.
Corp., Toronto, Canada M5S 3E5
Received December 27, 2009. Revised manuscript received
April 19, 2010. Accepted April 21, 2010.
The U.S. Environmental Protection Agency’s “Four Lab
Study” involved participation of researchers from four national
Laboratories and Centers of the Office of Research and
Development along with collaborators from the water industry and academia. The study evaluated toxicological effects of complex disinfection byproduct (DBP) mixtures, with an emphasis on reproductive and developmental effects that have been associated with DBP exposures in some human epidemiologic studies. This paper describes a new procedure for producing chlorinated drinking water concentrate for animal toxicology
Concentration, Chlorination, and
Chemical Analysis of Drinking Water for Disinfection Byproduct Mixtures
Health Effects Research: U.S. EPA’s
Four Lab Study
JONATHAN G. PRESSMAN,†
S U S A N D . R I C H A R D S O N , * ,‡
THOMAS F. SPETH,†
RICHARD J. MILTNER,†
MICHAEL G. NAROTSKY,§
E. SIDNEY HUNTER, III,§
GLENN E. RICE,| LINDA K. TEUSCHLER,|
ANTHONY MCDONALD,§
SHAHID PARVEZ,| STUART W. KRASNER,⊥
HOWARD S. WEINBERG,#
A. BRUCE MCKAGUE,∇
CHRISTOPHER J. PARRETT,†
N A T H A L I E B O D I N , #,O R U S S E L L C H I N N , ⊥
CHIH-FEN T. LEE,⊥ AND
JANE ELLEN SIMMONS§
National Risk Management Research Laboratory, U.S. EPA,
Cincinnati, Ohio 45268, National Exposure Research
Laboratory, U.S. EPA, Athens, Georgia 30605, National Health and Environmental Effects Research Laboratory, U.S. EPA,
Research Triangle Park, North Carolina 27711, National
Center for Environmental Risk Assessment, U.S. EPA,
Cincinnati, Ohio 45268, Metropolitan Water District of
Southern California, La Verne, California 91750, Gillings
School of Global Public Health, Department of Environmental
Sciences and Engineering, University of North Carolina,
Chapel Hill, North Carolina 27599-7431, and CanSyn Chem.
Corp., Toronto, Canada M5S 3E5
Received December 27, 2009. Revised manuscript received
April 19, 2010. Accepted April 21, 2010.
The U.S. Environmental Protection Agency’s “Four Lab
Study” involved participation of researchers from four national
Laboratories and Centers of the Office of Research and
Development along with collaborators from the water industry and academia. The study evaluated toxicological effects of complex disinfection byproduct (DBP) mixtures, with an emphasis on reproductive and developmental effects that have been associated with DBP exposures in some human epidemiologic studies. This paper describes a new procedure for producing chlorinated drinking water concentrate for animal toxicology