In chapter four, we are shown Victor's increasing isolation, shown through his response to the physical world and the degradation of his social life and morals. His excessive hubris forces him to continue on the quest for creation. He becomes physically ill because of the "days and nights in vaults and charnel houses," the "incredible labour and fatigue" finally taking its toll upon his body. His association with death reflects upon his life as he is slowly fading away. This shows the dangers and consequences of Victor's ambition and how he is destroying himself and his links with his friends because of the "unremitting ardour" with which he "pursued his undertaking." Shelley uses imagery and the metonymy of doom and gloom to convey the isolation which is a consequence of his ambition. This comes from Shelley's own fears of the industrial revolution and that the application of science can lead to unintended consequence.
Chapter five most conveys the ideas of responsibility of creation/ birth and is an image of Shelley's own fears of childbirth and pregnancy. As the book can often be seen as an allegory for the journey of pregnancy. Shelley's fears of stillbirth and maternal death- stillbirth