Dengue Haemorrhagic Fever: An Overview
Defn:Dengue Haemorrhagic Fever(DHF) are acute febrile diseases transmitted by mosquitoes, which occur in the tropics, can be life-threatening, and are caused by four closely related virus serotypes of the genus Flavivirus, family Flaviviridae.It was identified and named in 1779. It is also known as breakbone fever, since it can be extremely painful.
Causative Agent: . Dengue is transmitted to humans by the Aedes (Stegomyia) aegypti or more rarely the Aedes albopictus mosquito. The mosquitoes that spread dengue usually bite at dusk and dawn but may bite at any time during the day, especially indoors, in shady areas, or when the weather is cloudy.
Virology: Dengue fever is caused by Dengue virus (DENV), a mosquito-borne flavivirus.
DENV is an ssRNA positive-strand virus of the family Flaviviridae; genus Flavivirus.
There are four serotypes of DENV. viral serotypes: dengue virus 1 (DENV-1), dengue virus 2 (DENV-2), dengue virus 3 (DENV-3), and dengue virus 4 (DENV-4). Genetic studies of sylvatic strains suggest that the 4 viruses evolved from a common ancestor in primate populations approximately 1000 years ago and that all 4 viruses separately emerged into a human urban transmission cycle 500 years ago in either Asia or Africa.1,8 Albert Sabin speciated these viruses in 1944.
The virus has a genome of about 11000 bases that codes for three structural proteins, C, prM, E; seven nonstructural proteins, NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5; and short non-coding regions on both the 5' and 3' ends.
E protein The envelope protein, found on the viral surface, is important in the initial attachment of the viral particle to the host cell. Several molecules which interact with the viral E protein (ICAM3-grabbing non-integrin., CD209 ,Rab 5 , GRP 78 ,and The Mannose Receptor )have been shown to be important factors mediating attachment and viral entry. prM/M protein
The membrane protein, which is important in the formation and maturation of the viral particle,
Causative Agent: . Dengue is transmitted to humans by the Aedes (Stegomyia) aegypti or more rarely the Aedes albopictus mosquito. The mosquitoes that spread dengue usually bite at dusk and dawn but may bite at any time during the day, especially indoors, in shady areas, or when the weather is cloudy.
Virology: Dengue fever is caused by Dengue virus (DENV), a mosquito-borne flavivirus.
DENV is an ssRNA positive-strand virus of the family Flaviviridae; genus Flavivirus.
There are four serotypes of DENV. viral serotypes: dengue virus 1 (DENV-1), dengue virus 2 (DENV-2), dengue virus 3 (DENV-3), and dengue virus 4 (DENV-4). Genetic studies of sylvatic strains suggest that the 4 viruses evolved from a common ancestor in primate populations approximately 1000 years ago and that all 4 viruses separately emerged into a human urban transmission cycle 500 years ago in either Asia or Africa.1,8 Albert Sabin speciated these viruses in 1944.
The virus has a genome of about 11000 bases that codes for three structural proteins, C, prM, E; seven nonstructural proteins, NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5; and short non-coding regions on both the 5' and 3' ends.
E protein The envelope protein, found on the viral surface, is important in the initial attachment of the viral particle to the host cell. Several molecules which interact with the viral E protein (ICAM3-grabbing non-integrin., CD209 ,Rab 5 , GRP 78 ,and The Mannose Receptor )have been shown to be important factors mediating attachment and viral entry. prM/M protein
The membrane protein, which is important in the formation and maturation of the viral particle,