Dependence And Abuse In The 1950's
Before the 1950’s anxiety was mainly treated with barbiturates and meprobamate. However, these drugs have disadvantages linked to dependence and abuse. Consequently, there was a need for new medication with fewer side effects [1].
In the 1950’s, Sternbach, a chemist at Roche, started looking for a new anxiolytic. He started this process by using benzheptoxdiazines, molecules which he had previously worked with. He synthesised new compounds using his key product and secondary amines. After having worked on these compounds for over a year, only one had anxiolytic, sedative, anticonvulsant and muscle relaxation properties. The researchers eventually found out that the difference with the other non-active compounds was that for this particular
In the 1950’s, Sternbach, a chemist at Roche, started looking for a new anxiolytic. He started this process by using benzheptoxdiazines, molecules which he had previously worked with. He synthesised new compounds using his key product and secondary amines. After having worked on these compounds for over a year, only one had anxiolytic, sedative, anticonvulsant and muscle relaxation properties. The researchers eventually found out that the difference with the other non-active compounds was that for this particular